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Erschienen in: Journal of Materials Science 10/2021

03.01.2021 | Chemical routes to materials

Construction of a specific and efficient antibacterial agent against Pseudomonas aeruginosa based on polyethyleneimine cross-linked fucose

verfasst von: Mei Liu, Rong Guo, Yue Ma

Erschienen in: Journal of Materials Science | Ausgabe 10/2021

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Abstract

Polyethyleneimine (PEI) is known for its antibacterial properties and ease of modification. How to improve the specific antibacterial activity of PEI with low toxicity is a research hotspot. In this work, the PEI was used to synthesize a fucose-modified polyethyleneimine copolymer particles (Fuc-PEI CPs) via nucleophilic addition between primary amine and aldehyde groups. Fucose (Fuc) can capture Pseudomonas aeruginosa (P. aeruginosa) with LecB, which has a good targeting property toward P. aeruginosa. The Fuc-PEI CPs’ antibacterial activity was investigated by plate counting method. Compared with unmodified PEI, Fuc-PEI CPs (2.5 μg/mL) showed unique bactericidal ability against P. aeruginosa, and less cytotoxicity and excellent biocompatibility. The antimicrobial mechanism indicated that the improvement of PEI antibacterial activity against P. aeruginosa ascribed to the Fuc’s unique recognition of bacteria and PEIs’ ability to destroy the cell membrane of bacteria. The Fuc-PEI CPs as a new antibacterial agent shed light on the constructing a novel antibacterial pathway for killing P. aeruginosa.

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Metadaten
Titel
Construction of a specific and efficient antibacterial agent against Pseudomonas aeruginosa based on polyethyleneimine cross-linked fucose
verfasst von
Mei Liu
Rong Guo
Yue Ma
Publikationsdatum
03.01.2021
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 10/2021
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-020-05653-9

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