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Erschienen in: Medical & Biological Engineering & Computing 9/2015

01.09.2015 | Original Article

Continuous-wavelet-transform analysis of the multifocal ERG waveform in glaucoma diagnosis

verfasst von: J. M. Miguel-Jiménez, R. Blanco, L. De-Santiago, A. Fernández, J. M. Rodríguez-Ascariz, R. Barea, J. L. Martín-Sánchez, C. Amo, E. Sánchez-Morla, L. Boquete

Erschienen in: Medical & Biological Engineering & Computing | Ausgabe 9/2015

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Abstract

The vast majority of multifocal electroretinogram (mfERG) signal analyses to detect glaucoma study the signals’ amplitudes and latencies. The purpose of this paper is to investigate application of wavelet analysis of mfERG signals in diagnosis of glaucoma. This analysis method applies the continuous wavelet transform (CWT) to the signals, using the real Morlet wavelet. CWT coefficients resulting from the scale of maximum correlation are used as inputs to a neural network, which acts as a classifier. mfERG recordings are taken from the eyes of 47 subjects diagnosed with chronic open-angle glaucoma and from those of 24 healthy subjects. The high sensitivity in the classification (0.894) provides reliable detection of glaucomatous sectors, while the specificity achieved (0.844) reflects accurate detection of healthy sectors. The results obtained in this paper improve on the previous findings reported by the authors using the same visual stimuli and database.

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Literatur
1.
2.
Zurück zum Zitat Altman DG, Bland JM (1994) Statistics notes: diagnostic tests 2: predictive values. Br Med J 309(102):1 Altman DG, Bland JM (1994) Statistics notes: diagnostic tests 2: predictive values. Br Med J 309(102):1
3.
Zurück zum Zitat Bayer AU, Erb C (2002) Short-wavelength automated perimetry, frequency doubling technology perimetry and pattern electroretinography for prediction of progressive glaucomatous standard visual field defects. Ophthalmology 109:1009–1017CrossRefPubMed Bayer AU, Erb C (2002) Short-wavelength automated perimetry, frequency doubling technology perimetry and pattern electroretinography for prediction of progressive glaucomatous standard visual field defects. Ophthalmology 109:1009–1017CrossRefPubMed
4.
Zurück zum Zitat Bearse MA, Sutter EE, Stamper RL (2001) Detection of glaucomatous dysfunction using a global flash multifocal electroretinogram (mERG) paradigm. In: Sawchuk A (ed) Vision science and its applications. OSA technical digest series, vol 1. Optical Society of America, Washington, DC, pp 14–17 Bearse MA, Sutter EE, Stamper RL (2001) Detection of glaucomatous dysfunction using a global flash multifocal electroretinogram (mERG) paradigm. In: Sawchuk A (ed) Vision science and its applications. OSA technical digest series, vol 1. Optical Society of America, Washington, DC, pp 14–17
5.
Zurück zum Zitat Boquete L, Miguel-Jiménez JM, Ortega S, Rodríguez-Ascariz JM, Pérez-Rico C, Blanco R (2011) Multifocal electroretinogram diagnosis of glaucoma applying neural networks and structural pattern analysis. Expert Syst Appl 39:234–238CrossRef Boquete L, Miguel-Jiménez JM, Ortega S, Rodríguez-Ascariz JM, Pérez-Rico C, Blanco R (2011) Multifocal electroretinogram diagnosis of glaucoma applying neural networks and structural pattern analysis. Expert Syst Appl 39:234–238CrossRef
6.
Zurück zum Zitat Chu PH, Chan HH, Brown B (2006) Glaucoma detection is facilitated by luminance modulation of the global flash multifocal electroretinogram. Invest Ophthalmol Vis Sci 47:929–937CrossRefPubMed Chu PH, Chan HH, Brown B (2006) Glaucoma detection is facilitated by luminance modulation of the global flash multifocal electroretinogram. Invest Ophthalmol Vis Sci 47:929–937CrossRefPubMed
7.
Zurück zum Zitat Chu PH, Chan HH, Brown B (2007) Luminance-modulated adaptation of global flash mfERG: fellow eye losses in asymmetric glaucoma. Invest Ophthalmol Vis Sci 48:2626–2633CrossRefPubMed Chu PH, Chan HH, Brown B (2007) Luminance-modulated adaptation of global flash mfERG: fellow eye losses in asymmetric glaucoma. Invest Ophthalmol Vis Sci 48:2626–2633CrossRefPubMed
8.
Zurück zum Zitat Delgado MF, Nguyen NT, Cox TA et al (2002) Automated perimetry: a report by the American Academy of Ophthalmology. Ophthalmology 109:2362–2374CrossRefPubMed Delgado MF, Nguyen NT, Cox TA et al (2002) Automated perimetry: a report by the American Academy of Ophthalmology. Ophthalmology 109:2362–2374CrossRefPubMed
9.
Zurück zum Zitat Delprat N, Escudié B, Guillemain P, Kronland-Martinet R, Tchamitchian P, Torrésani B (1992) Asymptotic wavelet and Gabor analysis: extraction of instantaneous frequencies. IEEE Trans Inf Theory 38:644–664CrossRef Delprat N, Escudié B, Guillemain P, Kronland-Martinet R, Tchamitchian P, Torrésani B (1992) Asymptotic wavelet and Gabor analysis: extraction of instantaneous frequencies. IEEE Trans Inf Theory 38:644–664CrossRef
10.
Zurück zum Zitat Forte JD, Bui BV, Vingrys AJ (2008) Wavelet analysis reveals dynamics of rat oscillatory potentials. J Neurosci Methods 169:191–200CrossRefPubMed Forte JD, Bui BV, Vingrys AJ (2008) Wavelet analysis reveals dynamics of rat oscillatory potentials. J Neurosci Methods 169:191–200CrossRefPubMed
11.
Zurück zum Zitat Fortune B, Bearse MA, Cioffi GA, Johnson CA (2002) Selective loss of an oscillatory component from temporal retinal multifocal ERG responses in glaucoma. Invest Ophthalmol Vis Sci 43:2638–2647PubMed Fortune B, Bearse MA, Cioffi GA, Johnson CA (2002) Selective loss of an oscillatory component from temporal retinal multifocal ERG responses in glaucoma. Invest Ophthalmol Vis Sci 43:2638–2647PubMed
12.
Zurück zum Zitat Frishman LJ, Saszik S, Harwerth RS et al (2000) Effects of experimental glaucoma in macaques on the multifocal ERG: multifocal ERG in laser-induced glaucoma. Doc Ophthalmol Adv Ophthalmol 100:231–251CrossRef Frishman LJ, Saszik S, Harwerth RS et al (2000) Effects of experimental glaucoma in macaques on the multifocal ERG: multifocal ERG in laser-induced glaucoma. Doc Ophthalmol Adv Ophthalmol 100:231–251CrossRef
13.
Zurück zum Zitat Graham SL, Klistorner AI, Grigg JR, Billson FA (2000) Objective VEP perimetry in glaucoma: asymmetry analysis to identify early deficits. J Glaucoma 9:10–19CrossRefPubMed Graham SL, Klistorner AI, Grigg JR, Billson FA (2000) Objective VEP perimetry in glaucoma: asymmetry analysis to identify early deficits. J Glaucoma 9:10–19CrossRefPubMed
14.
Zurück zum Zitat Harwerth RS, Crawford ML, Frishman LJ, Viswanathan S, Smith EL, Carter-Dawson L (2002) Visual field defects and neural losses from experimental glaucoma. Prog Retin Eye Res 21:91–125CrossRefPubMed Harwerth RS, Crawford ML, Frishman LJ, Viswanathan S, Smith EL, Carter-Dawson L (2002) Visual field defects and neural losses from experimental glaucoma. Prog Retin Eye Res 21:91–125CrossRefPubMed
15.
Zurück zum Zitat Ho WC, Wong OY, Chan YC, Wong SW, Kee CS, Chan HH (2012) Sign-dependent changes in retinal electrical activity with positive and negative defocus in the human eye. Vis Res 52:47–53CrossRefPubMed Ho WC, Wong OY, Chan YC, Wong SW, Kee CS, Chan HH (2012) Sign-dependent changes in retinal electrical activity with positive and negative defocus in the human eye. Vis Res 52:47–53CrossRefPubMed
16.
Zurück zum Zitat Holder GE (2001) Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis. Prog Retin Eye Res 20:531–561CrossRefPubMed Holder GE (2001) Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis. Prog Retin Eye Res 20:531–561CrossRefPubMed
17.
Zurück zum Zitat Hood DC, Greenstein VC, Holopigian K et al (2000) An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG. Invest Ophthalmol Vis Sci 41:1570–1579PubMed Hood DC, Greenstein VC, Holopigian K et al (2000) An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG. Invest Ophthalmol Vis Sci 41:1570–1579PubMed
18.
Zurück zum Zitat Hood DC, Odel JG, Chen CS, Winn BJ (2003) The multifocal electroretinogram (ERG): applications and limitations in neuro-ophthalmology. J Neuroophthalmol 23:225–235CrossRefPubMed Hood DC, Odel JG, Chen CS, Winn BJ (2003) The multifocal electroretinogram (ERG): applications and limitations in neuro-ophthalmology. J Neuroophthalmol 23:225–235CrossRefPubMed
19.
Zurück zum Zitat Hood DC, Zhang X (2000) Multifocal ERG and VEP responses and visual fields: comparing disease-related changes. Doc Ophthalmol 100:115–137CrossRefPubMed Hood DC, Zhang X (2000) Multifocal ERG and VEP responses and visual fields: comparing disease-related changes. Doc Ophthalmol 100:115–137CrossRefPubMed
20.
Zurück zum Zitat Hori N, Komori S, Yamada H, Sawada A, Nomura Y, Mochizuki K, Yamamoto T (2012) Assessment of macular function of glaucomatous eyes by multifocal electroretinograms. Doc Ophthalmol Adv Ophthalmol 125:235–247CrossRef Hori N, Komori S, Yamada H, Sawada A, Nomura Y, Mochizuki K, Yamamoto T (2012) Assessment of macular function of glaucomatous eyes by multifocal electroretinograms. Doc Ophthalmol Adv Ophthalmol 125:235–247CrossRef
21.
Zurück zum Zitat Kook MS, Sung K, Kim S, Park R, Wang W (2001) Study of retinal nerve fiber layer thickness in eyes with high tension glaucoma and hemifield defect. Br J Ophthalmol 85:1167–1170PubMedCentralCrossRefPubMed Kook MS, Sung K, Kim S, Park R, Wang W (2001) Study of retinal nerve fiber layer thickness in eyes with high tension glaucoma and hemifield defect. Br J Ophthalmol 85:1167–1170PubMedCentralCrossRefPubMed
22.
Zurück zum Zitat Kumar R, Indrayan A (2011) Receiver operating characteristic (ROC) curve for medical researchers. Indian Pediatr 48:277–281CrossRefPubMed Kumar R, Indrayan A (2011) Receiver operating characteristic (ROC) curve for medical researchers. Indian Pediatr 48:277–281CrossRefPubMed
23.
Zurück zum Zitat Ledolter AA, Kramer SA, Todorova MG, Schötzau A, Palmowski-Wolf AM (2013) The effect of filtering on the two-global-flash mfERG: identifying the optimal range of frequency for detecting glaucomatous retinal dysfunction. Doc Ophthalmol 126:117–123CrossRefPubMed Ledolter AA, Kramer SA, Todorova MG, Schötzau A, Palmowski-Wolf AM (2013) The effect of filtering on the two-global-flash mfERG: identifying the optimal range of frequency for detecting glaucomatous retinal dysfunction. Doc Ophthalmol 126:117–123CrossRefPubMed
24.
Zurück zum Zitat Luo X, Patel NB, Harwerth RS, Frishman LJ (2011) Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma. Invest Ophthalmol Vis Sci 52:3792–3804PubMedCentralCrossRefPubMed Luo X, Patel NB, Harwerth RS, Frishman LJ (2011) Loss of the low-frequency component of the global-flash multifocal electroretinogram in primate eyes with experimental glaucoma. Invest Ophthalmol Vis Sci 52:3792–3804PubMedCentralCrossRefPubMed
25.
Zurück zum Zitat Medeiros FA, Zangwill LM, Bowd C, Weinreb RN (2004) Comparison of the Gdx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma. Arch Ophthalmol 122:827–837CrossRefPubMed Medeiros FA, Zangwill LM, Bowd C, Weinreb RN (2004) Comparison of the Gdx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma. Arch Ophthalmol 122:827–837CrossRefPubMed
26.
Zurück zum Zitat Miguel-Jiménez JM, Boquete L, Ortega S, Rodríguez-Ascariz JM, Blanco R (2010) Glaucoma detection by wavelet-based analysis of the global flash multifocal electroretinogram. Med Eng Phys 32:617–622CrossRefPubMed Miguel-Jiménez JM, Boquete L, Ortega S, Rodríguez-Ascariz JM, Blanco R (2010) Glaucoma detection by wavelet-based analysis of the global flash multifocal electroretinogram. Med Eng Phys 32:617–622CrossRefPubMed
27.
Zurück zum Zitat Miguel-Jiménez JM, Ortega S, Boquete L, Rodríguez-Ascariz JM, Blanco R (2011) Multifocal ERG wavelet packet decomposition applied to glaucoma diagnosis. Biomed Eng Online 10:37PubMedCentralCrossRefPubMed Miguel-Jiménez JM, Ortega S, Boquete L, Rodríguez-Ascariz JM, Blanco R (2011) Multifocal ERG wavelet packet decomposition applied to glaucoma diagnosis. Biomed Eng Online 10:37PubMedCentralCrossRefPubMed
28.
Zurück zum Zitat Palmowski-Wolfe AM, Todorova MG, Orgül S (2011) Multifocal oscillatory potentials in the ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma. J Clin Exp Ophthalmol 2:167. doi:10.4172/2155-9570.1000167 CrossRef Palmowski-Wolfe AM, Todorova MG, Orgül S (2011) Multifocal oscillatory potentials in the ‘two global flash’ mfERG in high and normal tension primary open-angle glaucoma. J Clin Exp Ophthalmol 2:167. doi:10.​4172/​2155-9570.​1000167 CrossRef
29.
Zurück zum Zitat Rangaswamy NV, Hood DC, Frishman LJ (2003) Regional variations in local contributions to the primate photopic flash ERG: revealed using the slow-sequence mfERG. Invest Ophthalmol Vis Sci 44:3233–3247CrossRefPubMed Rangaswamy NV, Hood DC, Frishman LJ (2003) Regional variations in local contributions to the primate photopic flash ERG: revealed using the slow-sequence mfERG. Invest Ophthalmol Vis Sci 44:3233–3247CrossRefPubMed
31.
Zurück zum Zitat Shimada Y, Li Y, Bearse MA, Sutter EE, Fung W (2001) Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br J Ophthalmol 85:414–419PubMedCentralCrossRefPubMed Shimada Y, Li Y, Bearse MA, Sutter EE, Fung W (2001) Assessment of early retinal changes in diabetes using a new multifocal ERG protocol. Br J Ophthalmol 85:414–419PubMedCentralCrossRefPubMed
32.
Zurück zum Zitat Sutter EE, Tran D (1992) The field topography of ERG components in man. I. The photopic luminance response. Vis Res 32:433–446CrossRefPubMed Sutter EE, Tran D (1992) The field topography of ERG components in man. I. The photopic luminance response. Vis Res 32:433–446CrossRefPubMed
33.
Zurück zum Zitat Sutter EE, Bearse MA (1999) The optic nerve head component of the human ERG. Vis Res 39:419–436CrossRefPubMed Sutter EE, Bearse MA (1999) The optic nerve head component of the human ERG. Vis Res 39:419–436CrossRefPubMed
34.
Zurück zum Zitat Todorova MG, Palmowski-Wolfe AM (2011) MfERG responses to long-duration white stimuli in glaucoma patients. Doc Ophthalmol Adv Ophthalmol 122:87–97CrossRef Todorova MG, Palmowski-Wolfe AM (2011) MfERG responses to long-duration white stimuli in glaucoma patients. Doc Ophthalmol Adv Ophthalmol 122:87–97CrossRef
35.
Zurück zum Zitat Wu LL, Suzuki Y, Kunimatsu S, Araie M, Iwase A, Tomita G (2001) Frequency doubling technology and confocal scanning ophthalmoscopic optic disc analysis in open-angle glaucoma with hemifield defect. J Glaucoma 10:256–260CrossRefPubMed Wu LL, Suzuki Y, Kunimatsu S, Araie M, Iwase A, Tomita G (2001) Frequency doubling technology and confocal scanning ophthalmoscopic optic disc analysis in open-angle glaucoma with hemifield defect. J Glaucoma 10:256–260CrossRefPubMed
36.
Metadaten
Titel
Continuous-wavelet-transform analysis of the multifocal ERG waveform in glaucoma diagnosis
verfasst von
J. M. Miguel-Jiménez
R. Blanco
L. De-Santiago
A. Fernández
J. M. Rodríguez-Ascariz
R. Barea
J. L. Martín-Sánchez
C. Amo
E. Sánchez-Morla
L. Boquete
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Medical & Biological Engineering & Computing / Ausgabe 9/2015
Print ISSN: 0140-0118
Elektronische ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-015-1287-6

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