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Erschienen in:
1992 | OriginalPaper | Buchkapitel
Cytotoxicity, Genotoxicity and Transforming Activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Rat Tracheal Epithelial Cells
verfasst von : S. Y. Zhu, M. L. Cunningham, T. E. Gray, P. Nettesheim
Erschienen in: Environmental Hygiene III
Verlag: Springer Berlin Heidelberg
Enthalten in: Professional Book Archive
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The causal relation between tobacco consumption and human cancer has been recognized for more than 50 years and NNK was considered to be the most potent carcinogenic tobacco specific nitrosamine. In present studies the cytotoxic, genotoxic and transforming effects of NNK in vivo and in vitro in rat tracheal epithelial (RTE) cells were investigated by the assays of colony forming efficiency (CFE), micronuclei formation (MN) and cell transformation frequency (TF).