Until recently, substance P was the only member of the neurokinin family of peptides of mammalian origin. Thus, sub-classification of neurokinin receptors as well as synthetic efforts to create a neurokinin antagonist utilized substance P as the prototypic peptide . Within the last three years, however, two additional mammalian peptides have been isolated. sequenced, purified and shown to have biological activities characteristic of the neurokinin family: neurokinin A and neurokinin B [2–4].
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- [D-Pro2,D-Trp6,8,Nle10]-Neurokinin B: Pharmacological Profile of a Novel Neurokinin Antagonist
J. L. Vaught
- Springer New York
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