Anzeige
Erschienen in:
2012 | OriginalPaper | Buchkapitel
Resolving the Three-Dimensional Histology of the Heart
verfasst von : Matthew Gibb, Rebecca A. B. Burton, Christian Bollensdorff, Carlos Afonso, Tahir Mansoori, Ulrich Schotten, Davig J. Gavaghan, Blanca Rodriguez, Jurgen E. Schneider, Peter Kohl, Vicente Grau
Erschienen in: Computational Methods in Systems Biology
Verlag: Springer Berlin Heidelberg
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
Cardiac histo-anatomical structure is a key determinant in all aspects of cardiac function. While some characteristics of micro- and macrostructure can be quantified using non-invasive imaging methods, histology is still the modality that provides the best combination of resolution and identification of cellular/sub-cellular substrate identities. The main limitation of histology is that it does not provide inherently consistent three-dimensional (3D) volume representations. This paper presents methods developed within our group to reconstruct 3D histological datasets. It includes the use of high-resolution MRI and block-face images to provide supporting volumetric datasets to guide spatial reintegration of 2D histological section data, and presents recent developments in sample preparation, data acquisition, and image processing.