Design of Novel Biosensors for Optical Sensing and Their Applications in Environmental Analysis

verfasst von: Dr. Kun Yin

Verlag: Springer Singapore

Buchreihe : Springer Theses

Enthalten in: Springer Professional "Wirtschaft+Technik" , Springer Professional "Technik"

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Über dieses Buch

This book introduces readers to the development of novel optical biosensors for environmental analysis. Environmental pollution has now become a serious problem, which threatens the health of human beings. Traditional analytical methods have a number of drawbacks, such as the need for professional operators and complicated instruments. After millions of years of evolution, biomolecules can perform various functions with good accuracy and efficiency due to their unique structures, offering a viable alternative to traditional methods.

This work focuses on using new biological sensing strategies, e.g. those based on special biomaterials, bio-reactions or living cells, to establish novel biosensors. As these biosensors offer satisfactory optical response performance, they can be used to transform the recognition behavior of specific targets into optical signals and effectively detect target objects.

Inhaltsverzeichnis

Frontmatter

Chapter 1. Introduction

Abstract

Optical biosensor usually consists of two components including a receptor and a transducer. Bioreceptor is a biomolecule that recognizes the target analyte, whereas the transducer converts the recognition event into a measurable optical signal.

Kun Yin

Chapter 2. A Fluorescent Biosensor for Copper Ion Detection

Abstract

Copper ion is an important structural component or cofactor for various enzymes, which plays important roles in biological physiological processes. However, over uptake of copper ion will induce oxidative stress in living cells, which leads to various diseases such as Alzheimer’s disease, Wilson disease, and Menkes disease.

Kun Yin

Chapter 3. Pyoverdine as a Biorecognition Element to Develop Biosensor for the Detection of Furazolidone

Abstract

Furazolidone is a nitrofuran drug, which is usually utilized to treat bacterial infections for aquaculture and poultry animals and protect them from death. However, furazolidone has potential genotoxic, carcinogenic, and mutagenic effects. For example, furazolidone shows strong mutagenic effect on Escherichia coli and Salmonella typhimurium, which can be used to kill these bacteria.

Kun Yin

Chapter 4. An Ultrasensitive Colorimetric Biosensor for Copper Ion Detection

Abstract

Copper ion is a type of micronutrients and plays important roles in metabolic processes of organisms. Copper ion can act as an essential cofactor of various enzymes such as nitrate reductase, cytochrome oxidase, and superoxide dismutase.

Kun Yin

Chapter 5. A Carboxylesterase E2-Based Biosensor to Simultaneously Remediate and Detect Mercury Ions

Abstract

Heavy metal pollution has already become a big public concern, which results from the development of industry as well as the expansion of population.

Kun Yin

Chapter 6. A Near-Infrared Ratiometric Fluorescent Probe to Selectively Detect Cysteine in Mitochondria for Indicating Oxidative Stress In Vivo

Abstract

Cysteine (Cys) is a type of intracellular biothiol, which plays important roles in numerous metabolic processes of organisms, such as heavy metal binding, biocatalysis, signal transduction, and protein turnover Reddie and Carroll (Curr Opin Chem Biol 12:746–754, 2008).

Kun Yin

Chapter 7. Conclusions

Abstract

During my Ph.D. study, my research focuses on the development of new biomaterials, new bioreaction, and new biological sensing strategies to establish novel biosensors toward environmental analysis. The established biosensors own satisfied optical response performance, which can be utilized to transform the recognition behavior of specific targets to optical signals and achieve the detection of target objects.

Kun Yin

Titel: Design of Novel Biosensors for Optical Sensing and Their Applications in Environmental Analysis
verfasst von: Dr. Kun Yin
Verlag: Springer Singapore
Electronic ISBN: 978-981-13-6488-4
Print ISBN: 978-981-13-6487-7
DOI: https://doi.org/10.1007/978-981-13-6488-4