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Erschienen in:
2011 | OriginalPaper | Buchkapitel
Designing Microarray Experiments
verfasst von : Paola Sebastiani, Jacqui Milton, Ling Wang
Erschienen in: Problem Solving Handbook in Computational Biology and Bioinformatics
Verlag: Springer US
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Gene expression microarrays have become an important exploratory tool in many screening experiments that aim to discover the genes that change expression in two or more biological conditions and can be used to build molecular profiles for both diagnostic and prognostic use. The still very high costs of microarrays and the difficulty in generating the biological samples are critical issues of microarraybased screening experiments, and the experimental design plays a crucial role in how informative an experiment is going to be. In this chapter, we describe some of the major issues related to the design of either randomized control trials or observational studies and discuss the choice of powerful sample sizes, the selection of informative experimental conditions, and experimental strategies that can minimize confounding. We conclude with a discussion of some of the open problems in the design and analysis of microarray experiments that need further research.