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Erschienen in:

2009 | OriginalPaper | Buchkapitel

4. Designing Trials for Testing the Efficacy of Pre- Pro- and Synbiotics

verfasst von : Stephen Lewis, Charlotte Atkinson

Erschienen in: Prebiotics and Probiotics Science and Technology

Verlag: Springer New York

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Abstract

Providing an evidence base for the rational delivery of medicines and treatments is the cornerstone of modern health care delivery. Much of this evidence base is gained through conducting clinical trials. Superficially, designing a clinical trial seems straightforward. However, in practice many unforeseen difficulties arise with long setting up times, poor recruitment rates and patients or interventions not behaving in the way expected. Unfortunately, clinical trials examining the efficacy of pre-, pro- and synbiotics have developed a reputation for being published in low impact journals and reaching unconvincing conclusions. As a generalization, the reason for this poor reputation is that the trials have tended to be too small and have not used meaningful clinical endpoints.

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Titel: Designing Trials for Testing the Efficacy of Pre- Pro- and Synbiotics
verfasst von: Stephen Lewis
Charlotte Atkinson
Verlag: Springer New York
Buch: Prebiotics and Probiotics Science and Technology
Print ISBN: 978-0-387-79057-2

Electronic ISBN: 978-0-387-79058-9

Copyright-Jahr: 2009
DOI: https://doi.org/10.1007/978-0-387-79058-9_4

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