2015 | OriginalPaper | Buchkapitel
Development and Characterization of Porous Calcium Phosphate Cement Using α-Tricalcium Phosphate Bead
verfasst von : Pham Trung Kien, Tsuru Kanji, Kunio Ishikawa
Erschienen in: 5th International Conference on Biomedical Engineering in Vietnam
Aktivieren Sie unsere intelligente Suche um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
Interconnected set porous-calcium phosphate cement (set porous-CPC), which has fully interconnected pores could be an ideal bone substitute. In this study, set porous-CPC consisting of (
α
-tricalcium phosphate (
α
-TCP) beads and acidic calcium phosphate solution was developed and its basic setting reaction was studied. When (
α
-TCP beads were exposed to the acidic calcium phosphate solution, brushite (CaHPO4∙2H2O) was formed on the surface of the (
α
-TCP beads. The formed brushite crystals interlocked with each other, resulting in a setting reaction of (
α
-TCP microspheres within 10 min at 37°C. As a result of this setting reaction, a fully-interconnected calcium phosphate macroporous structure was obtained. The set porous-CPC were immersed into simulated body fluid (SBF) at 37oC for different immersion time, The result clearly showed that brushite surface layer transformed to apatite layer after 3 days immersion into SBF solution by dissolution-precipitation reaction. Since apatite layer show excellent tissue response, the set porous-CPC would be a promising biomaterial used as artificial bone substitutes, and as the scaffold for tissue engineering.