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Erschienen in: Progress in Artificial Intelligence 3/2016

01.08.2016 | Regular Paper

Development of a clinical decision support system for antibiotic management in a hospital environment

verfasst von: Bernardo Cánovas-Segura, Manuel Campos, Antonio Morales, Jose M. Juarez, Francisco Palacios

Erschienen in: Progress in Artificial Intelligence | Ausgabe 3/2016

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Abstract

The rise of infections caused by multidrug-resistant bacteria has become a very important issue for health institutions around the world, urging them to a more appropriate use of antibiotics. Clinical decision support systems have a very important role in this area. We propose the development of a clinical decision support system focused on the antibiotic stewardship program implemented in hospitals. The need for a multi-user perspective, both reactive and proactive behaviours, and the use of many heterogeneous knowledge sources are identified as the main requirements that differentiate this clinical scenario from a decision support point of view. We show that a combination of production rules, ontologies, workflow modelling and subgroup discovery techniques could be used to fulfil these requirements. Finally, we describe a platform on which these techniques will be developed and tested.

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Literatur
1.
Zurück zum Zitat Clatworthy, A.E., Pierson, E., Hung, D.T.: Targeting virulence: a new paradigm for antimicrobial therapy. Nat. Chem. Biol. 3(9), 541–548 (2007)CrossRef Clatworthy, A.E., Pierson, E., Hung, D.T.: Targeting virulence: a new paradigm for antimicrobial therapy. Nat. Chem. Biol. 3(9), 541–548 (2007)CrossRef
2.
Zurück zum Zitat Piddock, L.J.: The crisis of no new antibiotics-what is the way forward? Lancet Infect. Dis. 12(3), 249–253 (2012)CrossRef Piddock, L.J.: The crisis of no new antibiotics-what is the way forward? Lancet Infect. Dis. 12(3), 249–253 (2012)CrossRef
3.
Zurück zum Zitat Spellberg, B.: The antibiotic crisis: can we reverse 65 years of failed stewardship? Arch. Intern. Med. 171(12), 1080–1081 (2011)CrossRef Spellberg, B.: The antibiotic crisis: can we reverse 65 years of failed stewardship? Arch. Intern. Med. 171(12), 1080–1081 (2011)CrossRef
4.
Zurück zum Zitat Centers for Disease Control and Prevention.: Antibiotic resistance threats in the United States (2013) Centers for Disease Control and Prevention.: Antibiotic resistance threats in the United States (2013)
5.
Zurück zum Zitat European Centre for Disease prevention and Control, European Medicines Agency.: The bacterial challenge: time to react (2009) European Centre for Disease prevention and Control, European Medicines Agency.: The bacterial challenge: time to react (2009)
7.
Zurück zum Zitat Doron, S., Davidson, L.E.: Antimicrobial stewardship. Mayo Clinic Proc. 86(11), 1113–1123 (2011)CrossRef Doron, S., Davidson, L.E.: Antimicrobial stewardship. Mayo Clinic Proc. 86(11), 1113–1123 (2011)CrossRef
8.
Zurück zum Zitat Magill, S.S., Edwards, J.R., Bamberg, W., Beldavs, Z.G., Dumyati, G., Kainer, M.A., Lynfield, R., Maloney, M., McAllister-Hollod, L., Nadle, J., Ray, S.M., Thompson, D.L., Wilson, L.E., Fridkin, S.K.: Multistate point-prevalence survey of health care-associated infections. N. Engl. J. Med. 370(13), 1198–1208 (2014)CrossRef Magill, S.S., Edwards, J.R., Bamberg, W., Beldavs, Z.G., Dumyati, G., Kainer, M.A., Lynfield, R., Maloney, M., McAllister-Hollod, L., Nadle, J., Ray, S.M., Thompson, D.L., Wilson, L.E., Fridkin, S.K.: Multistate point-prevalence survey of health care-associated infections. N. Engl. J. Med. 370(13), 1198–1208 (2014)CrossRef
9.
Zurück zum Zitat Nathan, C., Cars, O.: Antibiotic resistance—problems, progress, and prospects. N. Engl. J. Med. 371(19), 1761–1763 (2014)CrossRef Nathan, C., Cars, O.: Antibiotic resistance—problems, progress, and prospects. N. Engl. J. Med. 371(19), 1761–1763 (2014)CrossRef
10.
Zurück zum Zitat Carling, P., Fung, T., Killion, A., Terrin, N., Barza, M.: Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect. Control Hosp. Epidemiol. 24(9), 699–706 (2003)CrossRef Carling, P., Fung, T., Killion, A., Terrin, N., Barza, M.: Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect. Control Hosp. Epidemiol. 24(9), 699–706 (2003)CrossRef
11.
Zurück zum Zitat Schentag, J.J., Ballow, C.H., Fritz, A.L., Paladino, J.A., Williams, J.D., Cumbo, T.J., Ali, R.V., Galletta, V.A., Gutfeld, M.B., Adelman, M.H.: Changes in antimicrobial agent usage resulting from interactions among clinical pharmacy, the infectious disease division, and the microbiology laboratory. Diagn. Microbiol. Infect. Dis. 16(3), 255–264 (1993)CrossRef Schentag, J.J., Ballow, C.H., Fritz, A.L., Paladino, J.A., Williams, J.D., Cumbo, T.J., Ali, R.V., Galletta, V.A., Gutfeld, M.B., Adelman, M.H.: Changes in antimicrobial agent usage resulting from interactions among clinical pharmacy, the infectious disease division, and the microbiology laboratory. Diagn. Microbiol. Infect. Dis. 16(3), 255–264 (1993)CrossRef
12.
Zurück zum Zitat Sackett, D.L.: Evidence-based Medicine. In: Armitage, P., Colton, T. (eds.) Encyclopedia of Biostatistics. John Wiley & Sons Ltd, Chichester (2005) Sackett, D.L.: Evidence-based Medicine. In: Armitage, P., Colton, T. (eds.) Encyclopedia of Biostatistics. John Wiley & Sons Ltd, Chichester (2005)
13.
Zurück zum Zitat Barnett, G.O., Famiglietti, K.T., Kim, R.J., Hoffer, E.P., Feldman, M.J.: Dxplain on the internet. In: Proceedings of the AMIA Symposium, p. 607. American Medical Informatics Association (1998) Barnett, G.O., Famiglietti, K.T., Kim, R.J., Hoffer, E.P., Feldman, M.J.: Dxplain on the internet. In: Proceedings of the AMIA Symposium, p. 607. American Medical Informatics Association (1998)
14.
Zurück zum Zitat Kuperman, G.J., Gardner, R.M., Pryor, T.A.: HELP: A Dynamic Hospital Information System. Computers and Medicine. Springer, New York (1991) Kuperman, G.J., Gardner, R.M., Pryor, T.A.: HELP: A Dynamic Hospital Information System. Computers and Medicine. Springer, New York (1991)
15.
Zurück zum Zitat Ennis, J., Gillen, D., Rubenstein, A., Worcester, E., Brecher, M.E., Asplin, J., Coe, F.: Clinical decision support improves physician guideline adherence for laboratory monitoring of chronic kidney disease: a matched cohort study. BMC Nephrol. 16(1), 163 (2015)CrossRef Ennis, J., Gillen, D., Rubenstein, A., Worcester, E., Brecher, M.E., Asplin, J., Coe, F.: Clinical decision support improves physician guideline adherence for laboratory monitoring of chronic kidney disease: a matched cohort study. BMC Nephrol. 16(1), 163 (2015)CrossRef
16.
Zurück zum Zitat Trafton, J.A., Martins, S.B., Michel, M.C., Wang, D., Tu, S.W., Clark, D.J., Elliott, J., Vucic, B., Balt, S., Clark, M.E., Sintek, C.D., Rosenberg, J., Daniels, D., Goldstein, M.K.: Designing an automated clinical decision support system to match clinical practice guidelines for opioid therapy for chronic pain. Implement. Sci. 5(1), 26 (2010)CrossRef Trafton, J.A., Martins, S.B., Michel, M.C., Wang, D., Tu, S.W., Clark, D.J., Elliott, J., Vucic, B., Balt, S., Clark, M.E., Sintek, C.D., Rosenberg, J., Daniels, D., Goldstein, M.K.: Designing an automated clinical decision support system to match clinical practice guidelines for opioid therapy for chronic pain. Implement. Sci. 5(1), 26 (2010)CrossRef
17.
Zurück zum Zitat Calloway, S., Akilo, H.A., Bierman, K.: Impact of a clinical decision support system on pharmacy clinical interventions, documentation efforts, and costs. Hosp. Pharm. 48(9), 744–752 (2013)CrossRef Calloway, S., Akilo, H.A., Bierman, K.: Impact of a clinical decision support system on pharmacy clinical interventions, documentation efforts, and costs. Hosp. Pharm. 48(9), 744–752 (2013)CrossRef
18.
Zurück zum Zitat Forrest, G.N., Van Schooneveld, T.C., Kullar, R., Schulz, L.T., Duong, P., Postelnick, M.: Use of electronic health records and clinical decision support systems for antimicrobial stewardship. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 59 Suppl 3(Suppl 3), S122–S133 (2014) Forrest, G.N., Van Schooneveld, T.C., Kullar, R., Schulz, L.T., Duong, P., Postelnick, M.: Use of electronic health records and clinical decision support systems for antimicrobial stewardship. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 59 Suppl 3(Suppl 3), S122–S133 (2014)
19.
Zurück zum Zitat Pestotnik, S.L.: Expert clinical decision support systems to enhance antimicrobial stewardship programs: insights from the society of infectious diseases pharmacists. Pharmacotherapy 25(8), 1116–25 (2005)CrossRef Pestotnik, S.L.: Expert clinical decision support systems to enhance antimicrobial stewardship programs: insights from the society of infectious diseases pharmacists. Pharmacotherapy 25(8), 1116–25 (2005)CrossRef
20.
Zurück zum Zitat Belle, A., Kon, M.A., Najarian, K.: Biomedical informatics for computer-aided decision support systems: a survey. Sci. World J. 2013 769, 639 (2013) Belle, A., Kon, M.A., Najarian, K.: Biomedical informatics for computer-aided decision support systems: a survey. Sci. World J. 2013 769, 639 (2013)
21.
Zurück zum Zitat Mitchell, J.A., Gerdin, U., Lindberg, D.A.B., Lovis, C., Martin-Sanchez, F.J., Miller, R.A., Shortliffe, E.H., Leong, T.Y.: 50 years of informatics research on decision support: what’s next. Methods Inform. Med. 50(6), 525–535 (2011)CrossRef Mitchell, J.A., Gerdin, U., Lindberg, D.A.B., Lovis, C., Martin-Sanchez, F.J., Miller, R.A., Shortliffe, E.H., Leong, T.Y.: 50 years of informatics research on decision support: what’s next. Methods Inform. Med. 50(6), 525–535 (2011)CrossRef
22.
Zurück zum Zitat Sittig, D.F., Wright, A., Osheroff, J.A., Middleton, B., Teich, J.M., Ash, J.S., Campbell, E.M., Bates, D.W.: Grand challenges in clinical decision support. J. Biomed. Inform. 41(2), 387–392 (2008)CrossRef Sittig, D.F., Wright, A., Osheroff, J.A., Middleton, B., Teich, J.M., Ash, J.S., Campbell, E.M., Bates, D.W.: Grand challenges in clinical decision support. J. Biomed. Inform. 41(2), 387–392 (2008)CrossRef
23.
Zurück zum Zitat Greenes, R.A.: Chapter 1—definition, scope, and challenges. In: Greenes, R.A. (ed.) Clinical Decision Support, 2nd edn, pp. 3–47. Academic, Oxford (2014)CrossRef Greenes, R.A.: Chapter 1—definition, scope, and challenges. In: Greenes, R.A. (ed.) Clinical Decision Support, 2nd edn, pp. 3–47. Academic, Oxford (2014)CrossRef
24.
Zurück zum Zitat Greenes, R.A.: Chapter 3—features of computer-based clinical decision support. In: Greenes, R.A. (ed.) Clinical Decision Support, 2nd edn, pp. 111–144. Academic, Oxford (2014)CrossRef Greenes, R.A.: Chapter 3—features of computer-based clinical decision support. In: Greenes, R.A. (ed.) Clinical Decision Support, 2nd edn, pp. 111–144. Academic, Oxford (2014)CrossRef
25.
Zurück zum Zitat Cimino, J.J., Elhanan, G., Zeng, Q.: Supporting infobuttons with terminological knowledge. Proceedings: a conference of the American Medical Informatics Association/... AMIA Annual Fall Symposium. AMIA Fall Symposium, pp. 528–532 (1997) Cimino, J.J., Elhanan, G., Zeng, Q.: Supporting infobuttons with terminological knowledge. Proceedings: a conference of the American Medical Informatics Association/... AMIA Annual Fall Symposium. AMIA Fall Symposium, pp. 528–532 (1997)
26.
Zurück zum Zitat Nadkarni, P.M., Ohno-Machado, L., Chapman, W.W.: Natural language processing: an introduction. J. Am. Med. Inform. Assoc. 18(5), 544–551 (2011)CrossRef Nadkarni, P.M., Ohno-Machado, L., Chapman, W.W.: Natural language processing: an introduction. J. Am. Med. Inform. Assoc. 18(5), 544–551 (2011)CrossRef
27.
Zurück zum Zitat de Dombal, F.T., Leaper, D.J., Staniland, J.R., McCann, A.P., Horrocks, J.C.: Computer-aided diagnosis of acute abdominal pain. BMJ 2(5804), 9–13 (1972)CrossRef de Dombal, F.T., Leaper, D.J., Staniland, J.R., McCann, A.P., Horrocks, J.C.: Computer-aided diagnosis of acute abdominal pain. BMJ 2(5804), 9–13 (1972)CrossRef
29.
Zurück zum Zitat Shortliffe, E.: Computer-based medical consultations: MYCIN. American Elsevier, USA (1976) Shortliffe, E.: Computer-based medical consultations: MYCIN. American Elsevier, USA (1976)
30.
Zurück zum Zitat Warner, H.R., Haug, P., Bouhaddou, O., Lincoln, M., Warner, H., Sorenson, D., Williamson, J.W., Fan, C.: ILIAD as an Expert Consultant to Teach Differential Diagnosis. Proceedings of the Annual Symposium on Computer Application in Medical Care, pp. 371–376 (1988) Warner, H.R., Haug, P., Bouhaddou, O., Lincoln, M., Warner, H., Sorenson, D., Williamson, J.W., Fan, C.: ILIAD as an Expert Consultant to Teach Differential Diagnosis. Proceedings of the Annual Symposium on Computer Application in Medical Care, pp. 371–376 (1988)
31.
Zurück zum Zitat Peleg, M.: Computer-interpretable clinical guidelines: a methodological review. J. Biomed. Inform. 46(4), 744–763 (2013)CrossRef Peleg, M.: Computer-interpretable clinical guidelines: a methodological review. J. Biomed. Inform. 46(4), 744–763 (2013)CrossRef
32.
Zurück zum Zitat Combi, C., Keravnou-Papailiou, E., Shahar, Y.: Temporal Information Systems in Medicine. Springer, Boston (2010)CrossRef Combi, C., Keravnou-Papailiou, E., Shahar, Y.: Temporal Information Systems in Medicine. Springer, Boston (2010)CrossRef
33.
Zurück zum Zitat Lamma, E., Mello, P., Nanetti, A., Riguzzi, F., Storari, S., Valastro, G.: Artificial intelligence techniques for monitoring dangerous infections. IEEE Trans. Inform. Technol. Biomed. 10(1), 143–155 (2006)CrossRef Lamma, E., Mello, P., Nanetti, A., Riguzzi, F., Storari, S., Valastro, G.: Artificial intelligence techniques for monitoring dangerous infections. IEEE Trans. Inform. Technol. Biomed. 10(1), 143–155 (2006)CrossRef
34.
Zurück zum Zitat Lo, Y.S., Liu, C.T.: Development of a hospital-acquired infection surveillance information system by using service-oriented architecture technology. In: 2010 3rd International Conference on Computer Science and Information Technology, vol. 4, pp. 449–453. IEEE (2010) Lo, Y.S., Liu, C.T.: Development of a hospital-acquired infection surveillance information system by using service-oriented architecture technology. In: 2010 3rd International Conference on Computer Science and Information Technology, vol. 4, pp. 449–453. IEEE (2010)
35.
Zurück zum Zitat Steurbaut, K., Colpaert, K., Gadeyne, B., Depuydt, P., Vosters, P., Danneels, C., Benoit, D., Decruyenaere, J., De Turck, F.: COSARA: integrated service platform for infection surveillance and antibiotic management in the ICU. J. Med. Syst. 36, 3765–3775 (2012)CrossRef Steurbaut, K., Colpaert, K., Gadeyne, B., Depuydt, P., Vosters, P., Danneels, C., Benoit, D., Decruyenaere, J., De Turck, F.: COSARA: integrated service platform for infection surveillance and antibiotic management in the ICU. J. Med. Syst. 36, 3765–3775 (2012)CrossRef
36.
Zurück zum Zitat Lovis, C., Colaert, D., Stroetmann, V.N.: DebugIT for patient safety—improving the treatment with antibiotics through multimedia data mining of heterogeneous clinical data. Stud. Health Technol. Inform. 136, 641–646 (2008) Lovis, C., Colaert, D., Stroetmann, V.N.: DebugIT for patient safety—improving the treatment with antibiotics through multimedia data mining of heterogeneous clinical data. Stud. Health Technol. Inform. 136, 641–646 (2008)
37.
Zurück zum Zitat Schober, D., Boeker, M., Bullenkamp, J., Huszka, C., Depraetere, K., Teodoro, D., Nadah, N., Choquet, R., Daniel, C., Schulz, S.: The DebugIT core ontology: semantic integration of antibiotics resistance patterns. Stud. Health Technol. Inform. 160(Pt 2), 1060–1064 (2010) Schober, D., Boeker, M., Bullenkamp, J., Huszka, C., Depraetere, K., Teodoro, D., Nadah, N., Choquet, R., Daniel, C., Schulz, S.: The DebugIT core ontology: semantic integration of antibiotics resistance patterns. Stud. Health Technol. Inform. 160(Pt 2), 1060–1064 (2010)
38.
Zurück zum Zitat Teodoro, D., Pasche, E., Gobeill, J., Emonet, S., Ruch, P., Lovis, C.: Building a transnational biosurveillance network using semantic web technologies: requirements, design, and preliminary evaluation. J. Med. Internet Res. 14(3), e73 (2012)CrossRef Teodoro, D., Pasche, E., Gobeill, J., Emonet, S., Ruch, P., Lovis, C.: Building a transnational biosurveillance network using semantic web technologies: requirements, design, and preliminary evaluation. J. Med. Internet Res. 14(3), e73 (2012)CrossRef
39.
Zurück zum Zitat Berner, E.: Clinical decision support systems: state of the art. Agency Healthc. Res. Qual. 09, 4–20 (2009) Berner, E.: Clinical decision support systems: state of the art. Agency Healthc. Res. Qual. 09, 4–20 (2009)
40.
Zurück zum Zitat Wright, A., Goldberg, H., Hongsermeier, T., Middleton, B.: A description and functional taxonomy of rule-based decision support content at a large integrated delivery network. J. Am. Med. Inform. Assoc. 14(4), 489–496 (2007)CrossRef Wright, A., Goldberg, H., Hongsermeier, T., Middleton, B.: A description and functional taxonomy of rule-based decision support content at a large integrated delivery network. J. Am. Med. Inform. Assoc. 14(4), 489–496 (2007)CrossRef
41.
Zurück zum Zitat Musen, M.A., Shahar, Y., Shortliffe, E.H.: Clinical decision-support systems. Biomed. Inform. 30, 698–736 (2006)CrossRef Musen, M.A., Shahar, Y., Shortliffe, E.H.: Clinical decision-support systems. Biomed. Inform. 30, 698–736 (2006)CrossRef
42.
Zurück zum Zitat Busto, J., Varas, J.: Knowledge enabled services (KES) for decision support in control rooms. CESADS (KES) case study at ESA/ESOC. In: Proceedings of the 10th International Conference on Accelerator and Large Experimental Physics Control Systems (ICALEPCS), pp. 10–14, Geneva (2005) Busto, J., Varas, J.: Knowledge enabled services (KES) for decision support in control rooms. CESADS (KES) case study at ESA/ESOC. In: Proceedings of the 10th International Conference on Accelerator and Large Experimental Physics Control Systems (ICALEPCS), pp. 10–14, Geneva (2005)
43.
Zurück zum Zitat Hinkelmann, K., Probst, F., Thönssen, B.: Agile process management: framework and methodology. AAAI Spring Symposium—Technical Report SS-06-06(Imi), pp. 33–41 (2006) Hinkelmann, K., Probst, F., Thönssen, B.: Agile process management: framework and methodology. AAAI Spring Symposium—Technical Report SS-06-06(Imi), pp. 33–41 (2006)
44.
Zurück zum Zitat Bragaglia, S., Chesani, F., Ciampolini, A., Mello, P., Montali, M., Sottara, D.: An hybrid architecture integrating forward rules with fuzzy ontological reasoning. In: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 6076 LNAI, pp. 438–445 (2010) Bragaglia, S., Chesani, F., Ciampolini, A., Mello, P., Montali, M., Sottara, D.: An hybrid architecture integrating forward rules with fuzzy ontological reasoning. In: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 6076 LNAI, pp. 438–445 (2010)
45.
Zurück zum Zitat Sottara, D., Bragaglia, S., Mello, P., Pulcini, D., Luccarini, L., Giunchi, D.: Ontologies, Rules, Workflow and Predictive Models: Knowledge Assets for an EDSS. In: 6th International Congress on Environmental Modelling and Software. iEMSs’ 2012 Proceedings, pp. 204–211. Leipzig, Germany (2012) Sottara, D., Bragaglia, S., Mello, P., Pulcini, D., Luccarini, L., Giunchi, D.: Ontologies, Rules, Workflow and Predictive Models: Knowledge Assets for an EDSS. In: 6th International Congress on Environmental Modelling and Software. iEMSs’ 2012 Proceedings, pp. 204–211. Leipzig, Germany (2012)
46.
Zurück zum Zitat Van Hille, P., Jacques, J., Taillard, J., Rosier, A., Delerue, D., Burgun, A., Dameron, O.: Comparing Drools and ontology reasoning approaches for telecardiology decision support. Stud. Health Technol. Inform. 180, 300–304 (2012) Van Hille, P., Jacques, J., Taillard, J., Rosier, A., Delerue, D., Burgun, A., Dameron, O.: Comparing Drools and ontology reasoning approaches for telecardiology decision support. Stud. Health Technol. Inform. 180, 300–304 (2012)
47.
Zurück zum Zitat Leclercq, R., Cantón, R., Brown, D.F.J., Giske, C.G., Heisig, P., Macgowan, aP, Mouton, J.W., Nordmann, P., Rodloff, aC, Rossolini, G.M., Soussy, C.J., Steinbakk, M., Winstanley, T.G., Kahlmeter, G.: EUCAST expert rules in antimicrobial susceptibility testing. Clin. Microbiol. Infect. 19(2), 141–160 (2013)CrossRef Leclercq, R., Cantón, R., Brown, D.F.J., Giske, C.G., Heisig, P., Macgowan, aP, Mouton, J.W., Nordmann, P., Rodloff, aC, Rossolini, G.M., Soussy, C.J., Steinbakk, M., Winstanley, T.G., Kahlmeter, G.: EUCAST expert rules in antimicrobial susceptibility testing. Clin. Microbiol. Infect. 19(2), 141–160 (2013)CrossRef
48.
Zurück zum Zitat Motik, B., Patel-Schneider, P.F., Parsia, B., Bock, C., Fokoue, A., Haase, P., Hoekstra, R., Horrocks, I., Ruttenberg, A., Sattler, U., Smith, M.: OWL 2 web ontology language—structural specification and functional-style syntax, 2nd edn, pp. 1–133. Online (2012) Motik, B., Patel-Schneider, P.F., Parsia, B., Bock, C., Fokoue, A., Haase, P., Hoekstra, R., Horrocks, I., Ruttenberg, A., Sattler, U., Smith, M.: OWL 2 web ontology language—structural specification and functional-style syntax, 2nd edn, pp. 1–133. Online (2012)
49.
Zurück zum Zitat Horridge, M., Bechhofer, S.: The OWLAPI: a Java API for OWL ontologies. Semant. Web 2(1), 11–21 (2011) Horridge, M., Bechhofer, S.: The OWLAPI: a Java API for OWL ontologies. Semant. Web 2(1), 11–21 (2011)
51.
Zurück zum Zitat Proctor, M., Neale, M., Lin, P., Frandsen, M.: Drools documentation. Technical report, pp. 1–297 (2008) Proctor, M., Neale, M., Lin, P., Frandsen, M.: Drools documentation. Technical report, pp. 1–297 (2008)
55.
Zurück zum Zitat Federhen, S.: The NCBI taxonomy database. Nucleic Acids Res. 40(Database issue), D136–D143 (2012) Federhen, S.: The NCBI taxonomy database. Nucleic Acids Res. 40(Database issue), D136–D143 (2012)
56.
Zurück zum Zitat Schärli, N., Ducasse, S., Nierstrasz, O., Black, a: Traits: composable units of behaviour. Lecture Notes Comput. Sci. 2743, 248–274 (2003)CrossRef Schärli, N., Ducasse, S., Nierstrasz, O., Black, a: Traits: composable units of behaviour. Lecture Notes Comput. Sci. 2743, 248–274 (2003)CrossRef
57.
Zurück zum Zitat Shearer, R., Motik, B., Horrocks, I.: HermiT: a highly-efficient OWL reasoner. Complexity 432, 10 (2008) Shearer, R., Motik, B., Horrocks, I.: HermiT: a highly-efficient OWL reasoner. Complexity 432, 10 (2008)
58.
Zurück zum Zitat Clayton, P.D., Pryor, T.A., Wigertz, O.B., Hripcsak, G.: Issues and structures for sharing medical knowledge among decision-making systems: the 1989 Arden Homestead Retreat. In: Proceedings of the Annual Symposium on Computer Application in Medical Care. American Medical Informatics Association, pp. 116 (1989) Clayton, P.D., Pryor, T.A., Wigertz, O.B., Hripcsak, G.: Issues and structures for sharing medical knowledge among decision-making systems: the 1989 Arden Homestead Retreat. In: Proceedings of the Annual Symposium on Computer Application in Medical Care. American Medical Informatics Association, pp. 116 (1989)
59.
Zurück zum Zitat Adlassnig, K.P., Blacky, A., Koller, W.: Artificial-intelligence-based hospital-acquired infection control. Stud. Health Technol. Inform. 149, 103–110 (2009) Adlassnig, K.P., Blacky, A., Koller, W.: Artificial-intelligence-based hospital-acquired infection control. Stud. Health Technol. Inform. 149, 103–110 (2009)
60.
Zurück zum Zitat Jung, C.Y., Sward, Ka, Haug, P.J.: Executing medical logic modules expressed in ArdenML using Drools. J. Am. Med. Inform. Assoc. 19(4), 533–536 (2012)CrossRef Jung, C.Y., Sward, Ka, Haug, P.J.: Executing medical logic modules expressed in ArdenML using Drools. J. Am. Med. Inform. Assoc. 19(4), 533–536 (2012)CrossRef
61.
Zurück zum Zitat Peleg, M., Boxwala, aa, Bernstam, E., Tu, S., Greenes, Ra, Shortliffe, E.H.: Sharable representation of clinical guidelines in GLIF: relationship to the Arden Syntax. J. Biomed. Inform. 34(3), 170–181 (2001)CrossRef Peleg, M., Boxwala, aa, Bernstam, E., Tu, S., Greenes, Ra, Shortliffe, E.H.: Sharable representation of clinical guidelines in GLIF: relationship to the Arden Syntax. J. Biomed. Inform. 34(3), 170–181 (2001)CrossRef
62.
Zurück zum Zitat Shortliffe, E.H., Scott, A.C., Bischoff, M.B., Campbell, A.B., Van Melle, W., Jacobs, C.D.: ONCOCIN: an expert system for oncology protocol management. In: Proceedings of the 7th International Joint Conference on Artificial Intelligence - Volume 2 (IJCAI’81), pp. 876–881. Morgan Kaufmann Publishers Inc., San Francisco, CA (1981) Shortliffe, E.H., Scott, A.C., Bischoff, M.B., Campbell, A.B., Van Melle, W., Jacobs, C.D.: ONCOCIN: an expert system for oncology protocol management. In: Proceedings of the 7th International Joint Conference on Artificial Intelligence - Volume 2 (IJCAI’81), pp. 876–881. Morgan Kaufmann Publishers Inc., San Francisco, CA (1981)
63.
Zurück zum Zitat Musen, M.A., Carlson, R.W., Fagan, L.M., Deresinski, S.C., Shortliffe, E.H.: T-HELPER: automated support for community-based clinical research. Proceedings/the... Annual Symposium on Computer Application [sic] in Medical Care. Symposium on Computer Applications in Medical Care, pp. 719–23 (1992) Musen, M.A., Carlson, R.W., Fagan, L.M., Deresinski, S.C., Shortliffe, E.H.: T-HELPER: automated support for community-based clinical research. Proceedings/the... Annual Symposium on Computer Application [sic] in Medical Care. Symposium on Computer Applications in Medical Care, pp. 719–23 (1992)
64.
Zurück zum Zitat Mulyar, N., van der Aalst, W.M.P., Peleg, M.: A pattern-based analysis of clinical computer-interpretable guideline modeling languages. J. Am. Med. Inform. Assoc. JAMIA 14(6), 781–787 (2007)CrossRef Mulyar, N., van der Aalst, W.M.P., Peleg, M.: A pattern-based analysis of clinical computer-interpretable guideline modeling languages. J. Am. Med. Inform. Assoc. JAMIA 14(6), 781–787 (2007)CrossRef
65.
Zurück zum Zitat Osheroff, J.A., Teich, J., Levick, D., Saldana, L., Velasco, F., Sittig, D., Rogers, K., Jenders, R.: Improving Outcomes with Clinical Decision Support: An Implementer’s Guide. Healthcare Information and Management Systems Society, Chicago (2012) Osheroff, J.A., Teich, J., Levick, D., Saldana, L., Velasco, F., Sittig, D., Rogers, K., Jenders, R.: Improving Outcomes with Clinical Decision Support: An Implementer’s Guide. Healthcare Information and Management Systems Society, Chicago (2012)
66.
Zurück zum Zitat Tu, S.W., Campbell, J.R., Glasgow, J., Nyman, Ma., McClure, R., McClay, J., Parker, C., Hrabak, K.M., Berg, D., Weida, T., Mansfield, J.G., Musen, Ma., Abarbanel, R.M.: The SAGE guideline model: achievements and overview. J. Am. Med. Inform. Assoc. 14(5), 589–598 (2007)CrossRef Tu, S.W., Campbell, J.R., Glasgow, J., Nyman, Ma., McClure, R., McClay, J., Parker, C., Hrabak, K.M., Berg, D., Weida, T., Mansfield, J.G., Musen, Ma., Abarbanel, R.M.: The SAGE guideline model: achievements and overview. J. Am. Med. Inform. Assoc. 14(5), 589–598 (2007)CrossRef
67.
Zurück zum Zitat Rybak, M., Lomaestro, B., Rotschafer, J.C., Moellering, R., Craig, W., Billeter, M., Dalovisio, J.R., Levine, D.P., Reilly, C.: Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am. J. Health Syst. Pharm. 66(1), 82–98 (2009)CrossRef Rybak, M., Lomaestro, B., Rotschafer, J.C., Moellering, R., Craig, W., Billeter, M., Dalovisio, J.R., Levine, D.P., Reilly, C.: Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am. J. Health Syst. Pharm. 66(1), 82–98 (2009)CrossRef
68.
Zurück zum Zitat Landers, T., Apte, M., Hyman, S., Furuya, Y., Glied, S., Larson, E.: A comparison of methods to detect urinary tract infections using electronic data. Jt. Comm. J. Qual. Patient Saf. Jt. Comm. Res. 36(9), 411–417 (2010) Landers, T., Apte, M., Hyman, S., Furuya, Y., Glied, S., Larson, E.: A comparison of methods to detect urinary tract infections using electronic data. Jt. Comm. J. Qual. Patient Saf. Jt. Comm. Res. 36(9), 411–417 (2010)
69.
Zurück zum Zitat Beaudoin, M., Kabanza, F., Nault, V., Valiquette, L.: An antimicrobial prescription surveillance system that learns from experience. AI Mag. 35(1), 15–25 (2014) Beaudoin, M., Kabanza, F., Nault, V., Valiquette, L.: An antimicrobial prescription surveillance system that learns from experience. AI Mag. 35(1), 15–25 (2014)
70.
Zurück zum Zitat Ma, L., Tsui, F., Hogan, W.: A framework for infection control surveillance using association rules. AMIA annual symposium..., pp. 410–414 (2003) Ma, L., Tsui, F., Hogan, W.: A framework for infection control surveillance using association rules. AMIA annual symposium..., pp. 410–414 (2003)
71.
Zurück zum Zitat Lamma, E., Manservigi, M., Mello, P., Nanetti, A., Riguzzi, F., Storari, S.: The automatic discovery of alarm rules for the validation of microbiological data. In: Proceedings of Workshop on Intelligent Data Analysis in Medicine and Pharmacology (IDAMAP) (2001) Lamma, E., Manservigi, M., Mello, P., Nanetti, A., Riguzzi, F., Storari, S.: The automatic discovery of alarm rules for the validation of microbiological data. In: Proceedings of Workshop on Intelligent Data Analysis in Medicine and Pharmacology (IDAMAP) (2001)
72.
Zurück zum Zitat Samore, M.H., Bateman, K., Alder, S.C., Hannah, E., Donnelly, S., Stoddard, G.J., Haddadin, B., Rubin, M.A., Williamson, J., Stults, B., Rupper, R., Stevenson, K.: Clinical decision support and appropriateness of antimicrobial prescribing: a randomized trial. JAMA 294(18), 2305–2314 (2005)CrossRef Samore, M.H., Bateman, K., Alder, S.C., Hannah, E., Donnelly, S., Stoddard, G.J., Haddadin, B., Rubin, M.A., Williamson, J., Stults, B., Rupper, R., Stevenson, K.: Clinical decision support and appropriateness of antimicrobial prescribing: a randomized trial. JAMA 294(18), 2305–2314 (2005)CrossRef
73.
Zurück zum Zitat Leibovici, L., Paul, M., Nielsen, A.D., Tacconelli, E., Andreassen, S.: The TREAT project: decision support and prediction using causal probabilistic networks. Int. J. Antimicrob. Agents 30, 93–102 (2007)CrossRef Leibovici, L., Paul, M., Nielsen, A.D., Tacconelli, E., Andreassen, S.: The TREAT project: decision support and prediction using causal probabilistic networks. Int. J. Antimicrob. Agents 30, 93–102 (2007)CrossRef
74.
Zurück zum Zitat Fox, B.C., Shenk, G., Peterson, D., Spiegel, C.A., Maki, D.G.: Choosing more effective antimicrobial combinations for empiric antimicrobial therapy of serious gram-negative rod infections using a dual cross-table antibiogram. Am. J. Infect. Control 36(3), S57–S61 (2008) Fox, B.C., Shenk, G., Peterson, D., Spiegel, C.A., Maki, D.G.: Choosing more effective antimicrobial combinations for empiric antimicrobial therapy of serious gram-negative rod infections using a dual cross-table antibiogram. Am. J. Infect. Control 36(3), S57–S61 (2008)
75.
Zurück zum Zitat Herrera, F., Carmona, C.J., González, P., del Jesus, M.J.: An overview on subgroup discovery: foundations and applications. Knowl. Inform. Syst. 29(3), 495–525 (2011)CrossRef Herrera, F., Carmona, C.J., González, P., del Jesus, M.J.: An overview on subgroup discovery: foundations and applications. Knowl. Inform. Syst. 29(3), 495–525 (2011)CrossRef
76.
Zurück zum Zitat Wrobel, S.: An algorithm for multi-relational discovery of subgroups. Lecture Notes Comput. Sci. 1263(1997), 78–87 (1997)CrossRef Wrobel, S.: An algorithm for multi-relational discovery of subgroups. Lecture Notes Comput. Sci. 1263(1997), 78–87 (1997)CrossRef
77.
Zurück zum Zitat Umek, L., Zupan, B., Toplak, M., Morin, A., Chauchat, J.H., Makovec, G., Smrke, D.: Subgroup Discovery in Data Sets with Multi-dimensional Responses: A Method and a Case Study in Traumatology, pp. 265–274. Springer, Berlin (2009) Umek, L., Zupan, B., Toplak, M., Morin, A., Chauchat, J.H., Makovec, G., Smrke, D.: Subgroup Discovery in Data Sets with Multi-dimensional Responses: A Method and a Case Study in Traumatology, pp. 265–274. Springer, Berlin (2009)
78.
Zurück zum Zitat Abu-Hanna, A., Nannings, B., Dongelmans, D., Hasman, A.: PRIM versus CART in subgroup discovery: when patience is harmful. J. Biomed. Inform. 43(5), 701–708 (2010)CrossRef Abu-Hanna, A., Nannings, B., Dongelmans, D., Hasman, A.: PRIM versus CART in subgroup discovery: when patience is harmful. J. Biomed. Inform. 43(5), 701–708 (2010)CrossRef
79.
Zurück zum Zitat Gamberger, D., Lavrač, N., Krstačić, G.: Active subgroup mining: a case study in coronary heart disease risk group detection. Artif. Intell. Med. 28(1), 27–57 (2003)CrossRef Gamberger, D., Lavrač, N., Krstačić, G.: Active subgroup mining: a case study in coronary heart disease risk group detection. Artif. Intell. Med. 28(1), 27–57 (2003)CrossRef
80.
Zurück zum Zitat Carmona, C.J., Chrysostomou, C., Seker, H., del Jesus, M.J.: Fuzzy rules for describing subgroups from Influenza A virus using a multi-objective evolutionary algorithm. Appl. Soft Comput. 13(8), 3439–3448 (2013)CrossRef Carmona, C.J., Chrysostomou, C., Seker, H., del Jesus, M.J.: Fuzzy rules for describing subgroups from Influenza A virus using a multi-objective evolutionary algorithm. Appl. Soft Comput. 13(8), 3439–3448 (2013)CrossRef
81.
Zurück zum Zitat García, A., Charte, F., González, P., Carmona, C.J., del Jesús, M.J.: Usando Algoritmos de Descubrimiento de Subgrupos en R: El Paquete SDR. In: Actas de la XVI Conferencia de la Asociación Española para la Inteligencia Artificial, CAEPIA 2015, Albacete, Noviembre 9–12, 2015, pp. 739–748 (2015) García, A., Charte, F., González, P., Carmona, C.J., del Jesús, M.J.: Usando Algoritmos de Descubrimiento de Subgrupos en R: El Paquete SDR. In: Actas de la XVI Conferencia de la Asociación Española para la Inteligencia Artificial, CAEPIA 2015, Albacete, Noviembre 9–12, 2015, pp. 739–748 (2015)
82.
Zurück zum Zitat del Jesus, M.J., Gonzalez, P., Herrera, F.: Multiobjective genetic algorithm for extracting subgroup discovery fuzzy rules. In: 2007 IEEE Symposium on Computational Intelligence in Multi-Criteria Decision-Making, pp. 50–57. IEEE (2007) del Jesus, M.J., Gonzalez, P., Herrera, F.: Multiobjective genetic algorithm for extracting subgroup discovery fuzzy rules. In: 2007 IEEE Symposium on Computational Intelligence in Multi-Criteria Decision-Making, pp. 50–57. IEEE (2007)
83.
Zurück zum Zitat National Research Council.: Computational Technology for Effective Health Care: Immediate Steps and Strategic Directions. National Academies Press, Washington, D.C. (2009) National Research Council.: Computational Technology for Effective Health Care: Immediate Steps and Strategic Directions. National Academies Press, Washington, D.C. (2009)
84.
Zurück zum Zitat Institute of Medicine: Health IT and Patient Safety: Building Safer Systems for Better Care. National Academies Press, Washington, D.C. (2012) Institute of Medicine: Health IT and Patient Safety: Building Safer Systems for Better Care. National Academies Press, Washington, D.C. (2012)
85.
Zurück zum Zitat Rind, A.: Interactive information visualization to explore and query electronic health records. Foundations and Trends\(^{\textregistered }\) in Human–Computer Interaction. 5(3), 207–298 (2013) Rind, A.: Interactive information visualization to explore and query electronic health records. Foundations and Trends\(^{\textregistered }\) in Human–Computer Interaction. 5(3), 207–298 (2013)
86.
Zurück zum Zitat Chittaro, L., Combi, C., Trapasso, G.: Data mining on temporal data: a visual approach and its clinical application to hemodialysis. J. Vis. Lang. Comput. 14(6), 591–620 (2003)CrossRef Chittaro, L., Combi, C., Trapasso, G.: Data mining on temporal data: a visual approach and its clinical application to hemodialysis. J. Vis. Lang. Comput. 14(6), 591–620 (2003)CrossRef
87.
Zurück zum Zitat Pinciroli, F., Portoni, L., Combi, C., Violante, F.F.: WWW-based access to object-oriented clinical databases: the KHOSPAD project. Comput. Biol. Med. 28(5), 531–552 (1998)CrossRef Pinciroli, F., Portoni, L., Combi, C., Violante, F.F.: WWW-based access to object-oriented clinical databases: the KHOSPAD project. Comput. Biol. Med. 28(5), 531–552 (1998)CrossRef
88.
Zurück zum Zitat Shahar, Y., Goren-Bar, D., Boaz, D., Tahan, G.: Distributed, intelligent, interactive visualization and exploration of time-oriented clinical data and their abstractions. Artif. Intell. Med. 38(2), 115–135 (2006)CrossRef Shahar, Y., Goren-Bar, D., Boaz, D., Tahan, G.: Distributed, intelligent, interactive visualization and exploration of time-oriented clinical data and their abstractions. Artif. Intell. Med. 38(2), 115–135 (2006)CrossRef
89.
Zurück zum Zitat Klimov, D., Shahar, Y., Taieb-Maimon, M.: Intelligent interactive visual exploration of temporal associations among multiple time-oriented patient records. Methods Inform. Med. 48(3), 254–262 (2009)CrossRef Klimov, D., Shahar, Y., Taieb-Maimon, M.: Intelligent interactive visual exploration of temporal associations among multiple time-oriented patient records. Methods Inform. Med. 48(3), 254–262 (2009)CrossRef
90.
Zurück zum Zitat Wang, T.: Interactive visualization techniques for searching temporal categorical data. Ph.D. thesis, University of Maryland (2010) Wang, T.: Interactive visualization techniques for searching temporal categorical data. Ph.D. thesis, University of Maryland (2010)
91.
Zurück zum Zitat Lins, L., Heilbrun, M., Freire, J., Silva, C.: Viscaretrails: visualizing trails in the electronic health record with timed word trees, a pancreas cancer use case. In: AMIA Workshop on Visual Analytics in HealthCare (2013) Lins, L., Heilbrun, M., Freire, J., Silva, C.: Viscaretrails: visualizing trails in the electronic health record with timed word trees, a pancreas cancer use case. In: AMIA Workshop on Visual Analytics in HealthCare (2013)
92.
Zurück zum Zitat Beilken, C., Spenke, M.: Visual, interactive data mining with InfoZoom—the medical data set. In: Workshop notes on discovery challenge. In: Proceedings of the 3rd European Conference on Principles and Practice of Knowledge Discovery in Databases, 1999 Sept 15–18, pp. 49–54. Prague (1999) Beilken, C., Spenke, M.: Visual, interactive data mining with InfoZoom—the medical data set. In: Workshop notes on discovery challenge. In: Proceedings of the 3rd European Conference on Principles and Practice of Knowledge Discovery in Databases, 1999 Sept 15–18, pp. 49–54. Prague (1999)
93.
Zurück zum Zitat Gustafson, T.L.: Practical risk-adjusted quality control charts for infection control. Am. J. Infect. Control 28(6), 406–414 (2000)CrossRef Gustafson, T.L.: Practical risk-adjusted quality control charts for infection control. Am. J. Infect. Control 28(6), 406–414 (2000)CrossRef
94.
Zurück zum Zitat Garcia-caballero, H., Campos, M., Juarez, J.M., Palacios, F.: Visualization in clinical decision support system for antibiotic treatment. In: Actas de la XVI Conferencia de la Asociación Española para la Inteligencia Artificial, CAEPIA 2015, Albacete, Noviembre 9–12, 2015, pp. 71–80 (2015) Garcia-caballero, H., Campos, M., Juarez, J.M., Palacios, F.: Visualization in clinical decision support system for antibiotic treatment. In: Actas de la XVI Conferencia de la Asociación Española para la Inteligencia Artificial, CAEPIA 2015, Albacete, Noviembre 9–12, 2015, pp. 71–80 (2015)
95.
Zurück zum Zitat Zhu, Y., Sun, L., Garbarino, A., Schmidt, C., Fang, J., Chen, J.: PathRings: a web-based tool for exploration of ortholog and expression data in biological pathways. BMC Bioinform. 16(1), 165 (2015) Zhu, Y., Sun, L., Garbarino, A., Schmidt, C., Fang, J., Chen, J.: PathRings: a web-based tool for exploration of ortholog and expression data in biological pathways. BMC Bioinform. 16(1), 165 (2015)
96.
Zurück zum Zitat Lam, H., Bertini, E., Isenberg, P., Plaisant, C., Carpendale, S.: Empirical studies in information visualization: seven scenarios. IEEE Trans. Vis. Comput. Graph. 18(9), 1520–1536 (2012) Lam, H., Bertini, E., Isenberg, P., Plaisant, C., Carpendale, S.: Empirical studies in information visualization: seven scenarios. IEEE Trans. Vis. Comput. Graph. 18(9), 1520–1536 (2012)
97.
Zurück zum Zitat White, T.: Hadoop: The Definitive Guide. O’Reilly Media Inc., Sebastopol (2012) White, T.: Hadoop: The Definitive Guide. O’Reilly Media Inc., Sebastopol (2012)
98.
Zurück zum Zitat Zaharia, M., Chowdhury, M., Franklin, M.J., Shenker, S., Stoica, I.: Spark: cluster computing with working sets. In: Proceedings of the 2Nd USENIX Conference on Hot Topics in Cloud Computing. HotCloud’10, pp. 10–10. USENIX Association, Berkeley, CA, USA (2010) Zaharia, M., Chowdhury, M., Franklin, M.J., Shenker, S., Stoica, I.: Spark: cluster computing with working sets. In: Proceedings of the 2Nd USENIX Conference on Hot Topics in Cloud Computing. HotCloud’10, pp. 10–10. USENIX Association, Berkeley, CA, USA (2010)
100.
Zurück zum Zitat Schreiber, G., Akkermans, H., Anjewierden, A., Dehoog, R., Shadbolt, N., Vandevelde, W., Wielinga, B.: Knowledge Engineering and Management: The CommonKADS Methodology. The MIT Press, Cambridge (1999) Schreiber, G., Akkermans, H., Anjewierden, A., Dehoog, R., Shadbolt, N., Vandevelde, W., Wielinga, B.: Knowledge Engineering and Management: The CommonKADS Methodology. The MIT Press, Cambridge (1999)
101.
Zurück zum Zitat Beck, K., Beedle, M., van Bennekum, A., Cockburn, A., Cunningham, W., Fowler, M., Grenning, J., Highsmith, J., Hunt, A., Jeffries, R., Kern, J., Marick, B., Martin, R.C., Mellor, S., Schwaber, K., Sutherland, J., Thomas, D.: Manifesto for Agile Software Development (2001). http://www.agilemanifesto.org/ Beck, K., Beedle, M., van Bennekum, A., Cockburn, A., Cunningham, W., Fowler, M., Grenning, J., Highsmith, J., Hunt, A., Jeffries, R., Kern, J., Marick, B., Martin, R.C., Mellor, S., Schwaber, K., Sutherland, J., Thomas, D.: Manifesto for Agile Software Development (2001). http://​www.​agilemanifesto.​org/​
102.
Zurück zum Zitat Dingsøyr, T., Nerur, S., Balijepally, V., Moe, N.B.: A decade of agile methodologies: towards explaining agile software development. J. Syst. Softw. 85(6), 1213–1221 (2012)CrossRef Dingsøyr, T., Nerur, S., Balijepally, V., Moe, N.B.: A decade of agile methodologies: towards explaining agile software development. J. Syst. Softw. 85(6), 1213–1221 (2012)CrossRef
103.
Zurück zum Zitat Boussadi, A., Bousquet, C., Sabatier, B., Caruba, T., Durieux, P., Degoulet, P.: A business rules design framework for a pharmaceutical validation and alert system. Methods Inform. Med. 50(1), 36–50 (2011)CrossRef Boussadi, A., Bousquet, C., Sabatier, B., Caruba, T., Durieux, P., Degoulet, P.: A business rules design framework for a pharmaceutical validation and alert system. Methods Inform. Med. 50(1), 36–50 (2011)CrossRef
104.
Zurück zum Zitat Zacharias, V.: The agile development of rule bases. In: Barry, C. et al. (eds.) Information Systems Development: Challenges in Practice, Theory, and Education, vol. 1, pp. 93–104. Springer, Boston (2009) Zacharias, V.: The agile development of rule bases. In: Barry, C. et al. (eds.) Information Systems Development: Challenges in Practice, Theory, and Education, vol. 1, pp. 93–104. Springer, Boston (2009)
105.
Zurück zum Zitat Beck, K.: Embracing change with extreme programming. Computer 32(10), 70–77 (1999)CrossRef Beck, K.: Embracing change with extreme programming. Computer 32(10), 70–77 (1999)CrossRef
107.
Zurück zum Zitat Carayon, P., Schoofs Hundt, A., Karsh, B.-T., Gurses, A.P., Alvarado, C.J., Smith, M., Flatley Brennan, P.: Work system design for patient safety: the SEIPS model. Qual. Saf. Heal. Care. 15, i50–i58 (2006) Carayon, P., Schoofs Hundt, A., Karsh, B.-T., Gurses, A.P., Alvarado, C.J., Smith, M., Flatley Brennan, P.: Work system design for patient safety: the SEIPS model. Qual. Saf. Heal. Care. 15, i50–i58 (2006)
108.
Zurück zum Zitat Donabedian, A.: Evaluating the quality of medical care. Milbank Meml. Fund Q. 44(3), 166 (1966)CrossRef Donabedian, A.: Evaluating the quality of medical care. Milbank Meml. Fund Q. 44(3), 166 (1966)CrossRef
109.
Zurück zum Zitat Kaplan, B.: Evaluating informatics applications-clinical decision support systems literature review. Int. J. Med. Inform. 64(1), 15–37 (2001)CrossRef Kaplan, B.: Evaluating informatics applications-clinical decision support systems literature review. Int. J. Med. Inform. 64(1), 15–37 (2001)CrossRef
Metadaten
Titel
Development of a clinical decision support system for antibiotic management in a hospital environment
verfasst von
Bernardo Cánovas-Segura
Manuel Campos
Antonio Morales
Jose M. Juarez
Francisco Palacios
Publikationsdatum
01.08.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Progress in Artificial Intelligence / Ausgabe 3/2016
Print ISSN: 2192-6352
Elektronische ISSN: 2192-6360
DOI
https://doi.org/10.1007/s13748-016-0089-x

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