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Journal of Materials Science
Erschienen in: Journal of Materials Science 11/2019

04.03.2019 | Materials for life sciences

Development of a resveratrol–zein–dopamine–lecithin delivery system with enhanced stability and mucus permeation

verfasst von: Wenquan Huang, Shaomin Li, Zhixian Li, Wei Zhu, Shan Lu, Yanbin Jiang

Erschienen in: Journal of Materials Science | Ausgabe 11/2019

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Abstract

The development of multi-functional nanoparticles is important in overcoming the poor stability and low mucus permeation of traditional drug delivery systems. Hence, the encapsulation of a model drug, resveratrol (RES), into zein–polydopamine–lecithin (ZPLs) nanoparticles was investigated through a delicately controlled phase separation process. The surface of the nanoparticles obtained was successfully modified with lecithin, which endowed them with neutral and hydrophilic properties. Due to the strong charge repulsion of the particles, the fabricated ZPLs showed high stability under the conditions of a saline solution, various pH, long-term storage and high-speed centrifugation. In vitro study suggested that the RES exhibited remarkably sustained release performance after loading into ZPLs. The quantificational experiment of the Transwell system suggested that most of the ZPLs could pass through mucus and exhibited high mucus permeation. This study provides a new opportunity to prepare RES-ZPLs nanospheres as a smart drug nanocarrier, with enhanced stability and mucus permeation.
Vorheriger Artikel Synthesis of monodispersed ZnO@SiO2 nanoparticles for anti-UV aging application in highly transparent polymer-based nanocomposites
Nächster Artikel Melt spinning of nano-hydroxyapatite and polycaprolactone composite fibers for bone scaffold application

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Metadaten
Titel
Development of a resveratrol–zein–dopamine–lecithin delivery system with enhanced stability and mucus permeation
verfasst von
Wenquan Huang
Shaomin Li
Zhixian Li
Wei Zhu
Shan Lu
Yanbin Jiang
Publikationsdatum
04.03.2019
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 11/2019
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-019-03465-0

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