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Erschienen in:
2022 | OriginalPaper | Buchkapitel
DiffDomain Enables Identification of Structurally Reorganized Topologically Associating Domains
verfasst von : Dunming Hua, Ming Gu, Yanyi Du, Li Qi, Xiangjun Du, Zhidong Bai, Xiaopeng Zhu, Dechao Tian
Erschienen in: Research in Computational Molecular Biology
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Abstract
The recent development of mapping technologies, such as Hi-C, that probes the 3D genome organization reveals that a chromosome is divided into topologically associating domains (TADs). TADs are genomic regions where chromatin loci are more frequently interacting with chromatin loci from the same TADs rather than from other TADs. TADs are functional units for transcriptional regulation, such as constraining interactions between enhancers and promoters.