The striatum constitutes a pivotal component of the basal ganglia, Which is anatomically and functionally associated with several clinical syndromes like parkinsonism, schizophrenia and Huntington’s chorea. This nucleus is extensively and unilaterally innervated by dopamine (DA) containing fibres originating in the substantia nigra (SN), pars compacta (SNC), and it projects fibres to the globus pillidus, the entopeduncular nucleus and the SN. The striatonigral pathway is a major neuronal route by which motor information originated in the striatum is funnelled. This pathway is, however, heterogeneous since: (1) it contains neuronal fibres utilizing different kind of neurochemical messengers, and (2) it includes different functional units, representing outflow and feed-back loops (for reviews see 1).
Weitere Kapitel dieses Buchs durch Wischen aufrufen
- Different Functional Roles for Substance P and Dynorphin in the Striato-Nigral Pathways of the Rat
M. T. Sharp
- Springer New York
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