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2014 | OriginalPaper | Buchkapitel

67. Dimerization of Chemokine Receptors and its Novel Roles in Drug Discovery

verfasst von : Mingqing Wang, Baosheng Ge, Fang Huang

Erschienen in: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Verlag: Springer Berlin Heidelberg

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Abstract

G-protein-coupled receptors (GPCRs) comprise the largest family of integral membrane proteins and mediate most of the transmembrane signal transduction. Approximately 50 % of all marketed drugs target GPCRs, which makes this protein family the most important drug targets. Chemokine receptors belong to GPCRs, which were perceived as monomers decades ago. However, recently there are growing evidences indicating that most of GPCRs can form dimers or higher order oligomers. Some chemokine receptors are also found existing as homodimers or heterodimers. A large number of studies have suggested that homodimers or heterodimers may exhibit specific functions, which are different from their monomeric counterparts. Meanwhile, the appearance of dimers with new signaling properties gives new chance in the search for novel drug targets. In this review, we will mainly summarize the current knowledge of the dimerization of chemmokine receptors and its potential roles in drug discovery.

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Titel: Dimerization of Chemokine Receptors and its Novel Roles in Drug Discovery
verfasst von: Mingqing Wang
Baosheng Ge
Fang Huang
Verlag: Springer Berlin Heidelberg
Buch: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)
Print ISBN: 978-3-642-37921-5

Electronic ISBN: 978-3-642-37922-2

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-3-642-37922-2_67

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