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Erschienen in:
Microscale Technologies for Engineering Complex Tissue Structures Kapitel lesen Erstes Kapitel lesen

2016 | OriginalPaper | Buchkapitel

15. Drug-Eluting Nanotubes for Cellular Bioactivity

verfasst von : Sweetu Patel, Azhang Hamlekhan, Tolou Shokuhfar

Erschienen in: Microscale Technologies for Cell Engineering

Verlag: Springer International Publishing

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Abstract

Titanium nanotubes has been known for its multifunctional properties and its benefits have been further investigated in the field of biomedical implantations. The mechanism behind the cellular interaction with the nanotubes possessing different diameter has been reported in this chapter. High surface area and surface energy of these nanotubes make it a hydrophilic surface, which enhances the protein adsorption on the surface facilitating the adhesion of the cells to the substrate. Additionally, these nanotubes possess nano-topographical features that provide biomechanical cues for the cells to spread on the surface thereby triggering various intracellular reactions inside the cells allowing their differentiation and proliferation on the surface. Different diameter of the nanotubes allow protein adsorption with respective spacing and depending on the cellular interaction with those proteins, cells either proliferate or differentiate. Its drug reserving capability makes it a suitable surface for implants, which can provide efficient amount of drug to be delivered at the site of interest. The drug can be loaded based on the patients need and it can include, bone morphogenic protein, anti-inflammatory drug, or anti-infection drug etc. Additionally, slow and controlled release of drug from the polymer-encapsulated drug has been the current area of research, which supplies the drug in regular interval, has also been discussed in his chapter.

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Vorheriges Kapitel Nanoparticulate Systems for Controlling Monocyte/Macrophage Behavior
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Metadaten
Titel
Drug-Eluting Nanotubes for Cellular Bioactivity
verfasst von
Sweetu Patel
Azhang Hamlekhan
Tolou Shokuhfar
Copyright-Jahr
2016
Buch
Microscale Technologies for Cell Engineering

Print ISBN: 978-3-319-20725-4

Electronic ISBN: 978-3-319-20726-1

Copyright-Jahr: 2016

DOI
https://doi.org/10.1007/978-3-319-20726-1_15

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