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2018 | OriginalPaper | Buchkapitel

Early Diagnosis of Autism Disease by Multi-channel CNNs

verfasst von : Guannan Li, Mingxia Liu, Quansen Sun, Dinggang Shen, Li Wang

Erschienen in: Machine Learning in Medical Imaging

Verlag: Springer International Publishing

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Abstract

Currently there are still no early biomarkers to detect infants with risk of autism spectrum disorder (ASD), which is mainly diagnosed based on behavior observations at three or four years old. Since intervention efforts may miss a critical developmental window after 2 years old, it is significant to identify imaging-based biomarkers for early diagnosis of ASD. Although some methods using magnetic resonance imaging (MRI) for brain disease prediction have been proposed in the last decade, few of them were developed for predicting ASD in early age. Inspired by deep multi-instance learning, in this paper, we propose a patch-level data-expanding strategy for multi-channel convolutional neural networks to automatically identify infants with risk of ASD in early age. Experiments were conducted on the National Database for Autism Research (NDAR), with results showing that our proposed method can significantly improve the performance of early diagnosis of ASD.

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Literatur
1.
Zurück zum Zitat Newschaffer, C.J., et al.: The epidemiology of autism spectrum disorders. Dev. Disab. Res. Rev. 8, 151–161 (2002) Newschaffer, C.J., et al.: The epidemiology of autism spectrum disorders. Dev. Disab. Res. Rev. 8, 151–161 (2002)
2.
Zurück zum Zitat Filipek, P.A., et al.: The screening and diagnosis of autistic spectrum disorders. J. Autism Dev. Disorders 29, 439–484 (1999) Filipek, P.A., et al.: The screening and diagnosis of autistic spectrum disorders. J. Autism Dev. Disorders 29, 439–484 (1999)
3.
Zurück zum Zitat Baird, G., Cass, H., Slonims, V.: Diagnosis of autism. BMJ Brit. Med. J. 327, 488–493 (2003)CrossRef Baird, G., Cass, H., Slonims, V.: Diagnosis of autism. BMJ Brit. Med. J. 327, 488–493 (2003)CrossRef
4.
Zurück zum Zitat Chen, R., Jiao, Y., Herskovits, E.H.: Structural MRI in autism spectrum disorder. Pediatr. Res. 69, 63R (2011)CrossRef Chen, R., Jiao, Y., Herskovits, E.H.: Structural MRI in autism spectrum disorder. Pediatr. Res. 69, 63R (2011)CrossRef
5.
Zurück zum Zitat Schumann, C.M., et al.: The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J. Neurosci. 24, 6392 (2004)CrossRef Schumann, C.M., et al.: The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J. Neurosci. 24, 6392 (2004)CrossRef
6.
Zurück zum Zitat Greimel, E., et al.: Changes in grey matter development in autism spectrum disorder. Brain Struct. Funct 218, 929–942 (2013)CrossRef Greimel, E., et al.: Changes in grey matter development in autism spectrum disorder. Brain Struct. Funct 218, 929–942 (2013)CrossRef
7.
Zurück zum Zitat Thakkar, K.N., et al.: Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD). Brain 131, 2464–2478 (2008)CrossRef Thakkar, K.N., et al.: Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD). Brain 131, 2464–2478 (2008)CrossRef
8.
Zurück zum Zitat Ciresan, D.C., Meier, U., Masci, J., Maria Gambardella, L., Schmidhuber, J.: Flexible, high performance convolutional neural networks for image classification. In: IJCAI Proceedings-International Joint Conference on Artificial Intelligence, pp. 1237. Barcelona, Spain, (2011) Ciresan, D.C., Meier, U., Masci, J., Maria Gambardella, L., Schmidhuber, J.: Flexible, high performance convolutional neural networks for image classification. In: IJCAI Proceedings-International Joint Conference on Artificial Intelligence, pp. 1237. Barcelona, Spain, (2011)
9.
Zurück zum Zitat Sarraf, S., Tofighi, G.: DeepAD: Alzheimer′ s Disease Classification via Deep Convolutional Neural Networks using MRI and fMRI. bioRxiv 070441 (2016) Sarraf, S., Tofighi, G.: DeepAD: Alzheimer′ s Disease Classification via Deep Convolutional Neural Networks using MRI and fMRI. bioRxiv 070441 (2016)
10.
Zurück zum Zitat LeCun, Y.: LeNet-5, convolutional neural networks (2015). http://yann/.lecun.com/exdb/lenet20 LeCun, Y.: LeNet-5, convolutional neural networks (2015). http://​yann/​.​lecun.​com/​exdb/​lenet20
11.
Zurück zum Zitat Zhong, Z., Jin, L., Xie, Z.: High performance offline handwritten chinese character recognition using googlenet and directional feature maps. In: 13th International Conference on Document Analysis and Recognition (ICDAR), pp. 846–850. IEEE (2015) Zhong, Z., Jin, L., Xie, Z.: High performance offline handwritten chinese character recognition using googlenet and directional feature maps. In: 13th International Conference on Document Analysis and Recognition (ICDAR), pp. 846–850. IEEE (2015)
12.
Zurück zum Zitat Liu, M., Zhang, J., Adeli, E., Shen, D.: Landmark-based deep multi-instance learning for brain disease diagnosis. Med. Image Anal. 43, 157–168 (2018)CrossRef Liu, M., Zhang, J., Adeli, E., Shen, D.: Landmark-based deep multi-instance learning for brain disease diagnosis. Med. Image Anal. 43, 157–168 (2018)CrossRef
13.
Zurück zum Zitat Payakachat, N., Tilford, J.M., Ungar, W.J.: National Database for Autism Research (NDAR): Big data opportunities for health services research and health technology assessment. PharmacoEconomics 34, 127–138 (2016)CrossRef Payakachat, N., Tilford, J.M., Ungar, W.J.: National Database for Autism Research (NDAR): Big data opportunities for health services research and health technology assessment. PharmacoEconomics 34, 127–138 (2016)CrossRef
14.
Zurück zum Zitat Zhang, J., Gao, Y., Gao, Y., Munsell, B.C., Shen, D.: Detecting anatomical landmarks for fast Alzheimer’s disease diagnosis. IEEE Trans. Med. Imaging 35, 2524 (2016)CrossRef Zhang, J., Gao, Y., Gao, Y., Munsell, B.C., Shen, D.: Detecting anatomical landmarks for fast Alzheimer’s disease diagnosis. IEEE Trans. Med. Imaging 35, 2524 (2016)CrossRef
15.
Zurück zum Zitat Mardia, K.: Assessment of multinormality and the robustness of Hotelling’s T2 test. Appl. Stat., 163–171 (1975) Mardia, K.: Assessment of multinormality and the robustness of Hotelling’s T2 test. Appl. Stat., 163–171 (1975)
Metadaten
Titel
Early Diagnosis of Autism Disease by Multi-channel CNNs
verfasst von
Guannan Li
Mingxia Liu
Quansen Sun
Dinggang Shen
Li Wang
Copyright-Jahr
2018
DOI
https://doi.org/10.1007/978-3-030-00919-9_35