Substance P (SP) belongs to the family of tachykinin which are structurally related peptides. They are mainly found in non-mammalian tissues with the exception of SP . Two tachykinin related peptides, neurokinin A (NA), and neurokinin B (NB), have been discovered in mammalian tissues [see 2,3]. These mammalian tachykinins (NA and NB) are also structurally similar to SP with a conserved C-terminal (see Table 1). They also act on various SP-responsive tissues as that of SP, but with different pontencies . The effect of these peptides on smooth muscle contractilities have been studied extensively , but information concerning their effects on endocrine secretions is scarce. The first objective of the present experiments was designed to test their effect on gastric somatostatinlike immunoreactivity (SLI) release. In addition, the effect of kassinin (K), another tachykinin which has not been found in rat tissues was also tested. SP has been shown to inhibit both basal and stimulated SLI release .
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- Effect of Substance P and Neurokinins on the Endocrine Secretion of the Pancreas and Stomach
Y. N. Kwok
- Springer New York
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