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Erschienen in:
2010 | OriginalPaper | Buchkapitel
Effect of the Endothelial Glycocalyx Layer on the Transport of LDLs in the Artery
verfasst von : X. Liu, Y. B. Fan, X. Y. Deng
Erschienen in: 6th World Congress of Biomechanics (WCB 2010). August 1-6, 2010 Singapore
Verlag: Springer Berlin Heidelberg
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To test the hypothesis that the endothelial glycocalyx layer (EGL) may play a crucial role in protecting the artery from excessive infiltration of low density lipoproteins (LDLs), LDL transport in a multilayer artery model with EGL was simulated numerically under steady state flow conditions. The results showed that the increase in EGL thickness caused a sharp decrease in LDL concentration in intima, suggesting that an intact EGL might be crucial in protecting the arterial wall from excessive lipid infiltration/accumulation, hence can spare the arterial wall from atherosclerotic disease.