There is increasing evidence that kinins are modulators of neuronal function. Immunocytochemical and RIA studies have shown widespread distribution of kinins and substance P in rat brain [1,4]. Several pathways containing these peptides have been traced . Some of the kinins have been designated as neurotransmitters, whereas recently discovered neurokinins are yet to be explored for their neurotransmitter behaviour . Substance P and kinins induce intense depolarization of neurons when applied iontophoretically [6,7,9]. These neuropeptides exhibit structural similarity too. Kinins bind to specific high affinity binding sites, are potent vasodilators and elicit pressor response when injected in the rat brain. Their binding with the respective ligands depends on PH, time dose and ionic concentration . The studies on kinins in the developing brain are rather limited. In spite of their great neurophysiological and neuropharmacological significance, their exact mechanism of action is poorly understood. Hence in the present study, electrophysiological behaviour of different doses of bradykinin (BrK) was studied in the developing rat cerebral cortex by employing computerized EEG. The neurophysiological behaviour of NaloxoneHcl and Ca antagonist Gallopamil (I.P.) was also assessed in these animals.
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- Electrophysiological Correlates of Bradykinin and Other Neuropeptides in Developing Rat Cerebral Cortex
S. K. Sharma
- Springer New York
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