Burn healing is one of the most important problems of modern surgery due to the high percentage of burns among other traumas, high lethality and disability after the treatment for burns of high surface area. Problem of the covering of large burned surfaces is still a challenge. In present study, a novel electrospun nanofibrous material is proposed as a new material for burn dressing. Versatility of electrospinning nanofiber manufacturing method allows developing various types of micro- and nanofiber materials from biocompatible and biodegradable polymers, including chitosan. Samples of chitosan nanofiber mats were created and tested as wound dressings for IIIa and IIIb degree burns. It is shown that chitosan nanofiber dressings provide effective absorbtion of exudate, ventilation of the wound, protection from infection and stimulate the process of skin tissue regeneration. Degradation of these materials prevents mechanical damage of wound during removing. The influence of thickness of materials on regenerative processes and degradation is studied. Mechanical properties of nanofiber mats are investigated.
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- Electrospun Chitosan Nanofiber Materials as Burn Dressing
L. Y. Kossovich
I. V. Kirillova
- Springer Berlin Heidelberg