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2014 | OriginalPaper | Chapter

β-Band Peak in Local Field Potentials as a Marker of Clinical Improvement in Parkinson’s Disease after Deep Brain Stimulation

Authors : P. D. Frangou, K. P. Michmizos, P. Stathis, D. Sakas, K. S. Nikita

Published in: XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013

Publisher: Springer International Publishing

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Although locating the stimulation contact in Deep Brain Stimulation (DBS) requires a sub-mm-precision, it remains a trial-and-error, patient-specific procedure that is usually the main cause of post-operational side-effects. In this work, we used microelectrode recordings from Parkinson’s disease (PD) patients, acquired at the Neurosurgery Clinic, Evangelismos Hospital, Athens, Greece, to relate the

β

-band peak, a known neurophysiological signature of the sensorimotor pathways with the clinical outcome of DBS, as assessed by an expert neurologist after a follow-up of at least 1 year. By combining recordings from 5 microelectrodes, we estimated a summed

β

-band amplitude peak, per recording depth. We suggest that the maximum aggregate

β

-band peak is related to the stimulation target. We verified our method in 6 patients that responded well in a bilateral DBS treatment (average increase of Unified Parkinson’s Disease Rating scale by 32.6 ± 5.4). In 7 out of 12 hemispheres, the distance between the stimulation depth and that of the maximum

β

-band peak was 0 and for the rest cases that distance was smaller than 2 mm which is a typical effective radius of a stimulation point. Our method needs to be further supported by data acquired from patients with good and poor clinical responses after DBS.

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Metadata
Title
β-Band Peak in Local Field Potentials as a Marker of Clinical Improvement in Parkinson’s Disease after Deep Brain Stimulation
Authors
P. D. Frangou
K. P. Michmizos
P. Stathis
D. Sakas
K. S. Nikita
Copyright Year
2014
DOI
https://doi.org/10.1007/978-3-319-00846-2_454