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Cognitive Neurodynamics

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01-08-2016 | Research Article

A model of cooperative effect of AMPA and NMDA receptors in glutamatergic synapses

Authors: Vito Di Maio, Francesco Ventriglia, Silvia Santillo

Published in: Cognitive Neurodynamics | Issue 4/2016

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Abstract

Glutamatergic synapses play a pivotal role in brain excitation. The synaptic response is mediated by the activity of two receptor types (AMPA and NMDA). In the present paper we propose a model of glutamatergic synaptic activity where the fast current generated by the AMPA conductance produces a local depolarization which activates the voltage- and [Mg²⁺]-dependent NMDA conductance. This cooperative effect is dependent on the biophysical properties of the synaptic spine which can be considered a high input resistance specialized compartment. Herein we present results of simulations where different values of the spine resistance and of the Mg²⁺ concentrations determine different levels of cooperativeness between AMPA and NMDA receptors in shaping the post-synaptic response.

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Title: A model of cooperative effect of AMPA and NMDA receptors in glutamatergic synapses
Authors: Vito Di Maio
Francesco Ventriglia
Silvia Santillo
Publication date: 01-08-2016
Publisher: Springer Netherlands
Published in: Cognitive Neurodynamics / Issue 4/2016
Print ISSN: 1871-4080
Electronic ISSN: 1871-4099
DOI: https://doi.org/10.1007/s11571-016-9383-3

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