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Application of Neural Network and Finite Element Method for Multiscale Prediction of Bone Fatigue Crack Growth in Cancellous Bone Read chapter Read first chapter

2013 | OriginalPaper | Chapter

A Model of Electromechanical Coupling in the Small Intestine

Authors : Peng Du , Jeelean Lim, Leo K. Cheng

Published in: Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Publisher: Springer Berlin Heidelberg

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Abstract

The motility of the intestines is partly governed by a bioelectrical activity termed intestinal slow wave activity; however, the dynamics of the electromechanical relationship have remained poorly defined. With the recent advances in continuum-based multi-scale modeling techniques, we present a modeling framework to investigate the electromechanical coupling in a segment of small intestine. The overall modeling framework included three parts: (i) an anatomical model describing the geometry and makeup of the smooth muscle fibers; (ii) an electrical model describing the slow wave propagation; and (iii) a mechanical model describing the active and passive tension laws during contraction. The resultant intraluminal pressure was approximated using Lamé’s thick-walled cylinder equation. This modeling framework demonstrates the potential to be used in investigating the effects of intestinal slow wave dysrhythmias on the motility of the small intestine, and may be extended in the future to incorporate additional regulatory factors and pathways.

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Metadata
Title
A Model of Electromechanical Coupling in the Small Intestine
Authors
Peng Du
Jeelean Lim
Leo K. Cheng
Copyright Year
2013
Publisher
Springer Berlin Heidelberg
Book
Multiscale Computer Modeling in Biomechanics and Biomedical Engineering

Print ISBN: 978-3-642-36481-5

Electronic ISBN: 978-3-642-36482-2

Copyright Year: 2013

DOI
https://doi.org/10.1007/8415_2012_153