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Average Cost Markov Decision Processes with Semi-Uniform Feller Transition Probabilities Read chapter Read first chapter

2021 | OriginalPaper | Chapter

A Regulatory Principle for Robust Reciprocal-Time Decay of the Adaptive Immune Response

Author : Anthony Almudevar

Published in: Modern Trends in Controlled Stochastic Processes:

Publisher: Springer International Publishing

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Abstract

Follicular dendritic cells (FDC) play a crucial role in the regulation of immunity. They are believed to be responsible for long-term persistence of humoral antibody following vaccination or infection, due to their role in antibody response induction and their ability to retain antigen for long periods. In this paper, a regulatory control model is described which links persistence of humoral immunity with cellular processes associated with FDCs. The model predicts universal and stable reciprocal-time (= 1/t) decay of humoral antibody levels, which has been widely reported over a range of ages, observation times and vaccine types.

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Metadata
Title
A Regulatory Principle for Robust Reciprocal-Time Decay of the Adaptive Immune Response
Author
Anthony Almudevar
Copyright Year
2021
Book
Modern Trends in Controlled Stochastic Processes:

Print ISBN: 978-3-030-76927-7

Electronic ISBN: 978-3-030-76928-4

Copyright Year: 2021

DOI
https://doi.org/10.1007/978-3-030-76928-4_15

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