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Lifetime Data Analysis

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23-09-2019

A semiparametric additive rates model for the weighted composite endpoint of recurrent and terminal events

Authors: Xiaowei Sun, Jieli Ding, Liuquan Sun

Published in: Lifetime Data Analysis | Issue 3/2020

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Abstract

Recurrent event data with a terminal event commonly arise in longitudinal follow-up studies. We use a weighted composite endpoint of all recurrent and terminal events to assess the overall effects of covariates on the two types of events. A semiparametric additive rates model is proposed to analyze the weighted composite event process and the dependence structure among recurrent and terminal events is left unspecified. An estimating equation approach is developed for inference, and the asymptotic properties of the resulting estimators are established. The finite-sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a bladder cancer study is illustrated.

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Title: A semiparametric additive rates model for the weighted composite endpoint of recurrent and terminal events
Authors: Xiaowei Sun
Jieli Ding
Liuquan Sun
Publication date: 23-09-2019
Publisher: Springer US
Published in: Lifetime Data Analysis / Issue 3/2020
Print ISSN: 1380-7870
Electronic ISSN: 1572-9249
DOI: https://doi.org/10.1007/s10985-019-09486-w

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