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Polymer Science, Series B
Published in: Polymer Science, Series B 5/2020

07-08-2020 | MEDICAL POLYMERS

A Thermal-Responsive Y-Shaped Miktoarm Amphiphilic Block Copolymer Composed of Poly(ε-caprolactone) and Poly(N-isopropylacrylamide) as a Nano-micellar Carrier for Anti-cancer Drugs

Authors: Farnaz Fazlalizadeh, Bakhshali Massoumi, Alireza Banaei, Mehdi Jaymand

Published in: Polymer Science, Series B | Issue 5/2020

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Abstract

A thermal-responsive Y-shaped amphiphilic block copolymer, namely poly(N-isopropylacrylamide-block-[poly(ε-caprolactone)]2 (PNIPAAm-b-PCL2), was synthesized through the combination of atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP) techniques, and its potential as smart anti-cancer drug delivery system was investigated preliminary. The fabricated polymers were characterized using FTIR and 1H NMR spectroscopy, and GPC analysis. The self-assembly behavior of the fabricated PNIPAAm-b-PCL2 copolymer under thermal stimuli was investigated using dynamic light scattering and UV–Vis spectroscopy. The lower critical solution temperature of the synthesized PNIPAAm-b-PCL2 was found to be 39–41°C. The doxorubicin hydrochloride loading and encapsulation capacities of the fabricated PNIPAAm-b-PCL2 were calculated to be 62 ± 3%, and 75 ± 4%, respectively; the drug release value was up to 46.5% during 40 h at 37°C and up to 88% at 40°C.
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next article Preparation of Filtration Membrane by Grafting of Poly(N-vinylpyrrolidone) onto Polyethersulfone and Its Influence on Pollution Resistance of Membrane

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Metadata
Title
A Thermal-Responsive Y-Shaped Miktoarm Amphiphilic Block Copolymer Composed of Poly(ε-caprolactone) and Poly(N-isopropylacrylamide) as a Nano-micellar Carrier for Anti-cancer Drugs
Authors
Farnaz Fazlalizadeh
Bakhshali Massoumi
Alireza Banaei
Mehdi Jaymand
Publication date
07-08-2020
Publisher
Pleiades Publishing
Published in
Polymer Science, Series B / Issue 5/2020
Print ISSN: 1560-0904
Electronic ISSN: 1555-6123
DOI
https://doi.org/10.1134/S1560090420050061

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