Skip to main content
Top

2021 | OriginalPaper | Chapter

A Three-Level Linearized Time Integration Scheme for Tumor Simulations with Cahn-Hilliard Equations

Authors : Maciej Smołka, Maciej Woźniak, Robert Schaefer

Published in: Computational Science – ICCS 2021

Publisher: Springer International Publishing

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

The paper contains an analysis of a three-level linearized time integration scheme for Cahn-Hilliard equations. We start with a rigorous mixed strong/variational formulation of the appropriate initial boundary value problem taking into account the existence and uniqueness of its solution. Next we pass to the definition of two time integration schemes: the Crank-Nicolson and a three-level linearized ones. Both schemes are applied to the discrete version of Cahn-Hilliard equation obtained through the Galerkin approximation in space. We prove that the sequence of solutions of the mixed three level finite difference scheme combined with the Galerkin approximation converges when the time step length and the space approximation error decrease. We also recall the verification of the second order of this scheme and its unconditional stability with respect to the time variable. A comparative scalability analysis of parallel implementations of the schemes is also presented.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Appendix
Available only for authorised users
Literature
1.
go back to reference Gómez, H., Calo, V.M., Bazileves, Y., Hughes, T.J.R.: Isogeometric analysis of the Cahn-Hilliard phase-field model. Comput. Methods Appl. Mech. Eng. 197, 4333–4352 (2008)MathSciNetCrossRef Gómez, H., Calo, V.M., Bazileves, Y., Hughes, T.J.R.: Isogeometric analysis of the Cahn-Hilliard phase-field model. Comput. Methods Appl. Mech. Eng. 197, 4333–4352 (2008)MathSciNetCrossRef
2.
go back to reference Gómez, H., Hughes, T.J.R.: Provably unconditionally stable, second-order time-accurate, mixed variational methods for phase-field models. J. Comput. Phys. 230, 5310–5327 (2011)MathSciNetCrossRef Gómez, H., Hughes, T.J.R.: Provably unconditionally stable, second-order time-accurate, mixed variational methods for phase-field models. J. Comput. Phys. 230, 5310–5327 (2011)MathSciNetCrossRef
4.
go back to reference Wu, X., van Zwieten, G.J., van der Zee, K.: Stabilized second-order convex splitting schemes for Cahn-Hilliard models with application to diffuse-interface tumor-growth models. Numer. Methods Biomech. Eng. 30(3), 180–203 (2014)MathSciNetCrossRef Wu, X., van Zwieten, G.J., van der Zee, K.: Stabilized second-order convex splitting schemes for Cahn-Hilliard models with application to diffuse-interface tumor-growth models. Numer. Methods Biomech. Eng. 30(3), 180–203 (2014)MathSciNetCrossRef
5.
go back to reference Łoś, M., Kłusek, A., Hassaan, M.A., Pingali, K., Dzwinel, W., Paszyński, M.: Parallel fast isogeometric L2 projection solver with GALOIS system for 3D tumor growth simulations. Comput. Methods Appl. Mech. Eng. 343, 1–22 (2019)MathSciNetCrossRef Łoś, M., Kłusek, A., Hassaan, M.A., Pingali, K., Dzwinel, W., Paszyński, M.: Parallel fast isogeometric L2 projection solver with GALOIS system for 3D tumor growth simulations. Comput. Methods Appl. Mech. Eng. 343, 1–22 (2019)MathSciNetCrossRef
6.
go back to reference Puzyrev, V., Łoś, M., Gurgul, G., Calo, V.M., Dzwinel, W., Paszyński, M.: Parallel splitting solvers for the isogeometric analysis of the Cahn-Hilliard equation. Comput. Methods Biomech. Biomed. Eng. 22(16), 1269–1281 (2019)CrossRef Puzyrev, V., Łoś, M., Gurgul, G., Calo, V.M., Dzwinel, W., Paszyński, M.: Parallel splitting solvers for the isogeometric analysis of the Cahn-Hilliard equation. Comput. Methods Biomech. Biomed. Eng. 22(16), 1269–1281 (2019)CrossRef
7.
go back to reference Woźniak, M., Smołka, M., Cortes, A., Paszyński, M., Schaefer, R.: Scalability of direct solver for non-stationary Cahn-Hilliard simulations with linearized time integration scheme. Procedia Comput. Sci. 80, 834–844 (2016)CrossRef Woźniak, M., Smołka, M., Cortes, A., Paszyński, M., Schaefer, R.: Scalability of direct solver for non-stationary Cahn-Hilliard simulations with linearized time integration scheme. Procedia Comput. Sci. 80, 834–844 (2016)CrossRef
8.
go back to reference Elliott, C.M., Garcke, H.: On the Cahn-Hilliard equation with degenerate mobility. SIAM J. Math. Anal. 27, 404–423 (1996)MathSciNetCrossRef Elliott, C.M., Garcke, H.: On the Cahn-Hilliard equation with degenerate mobility. SIAM J. Math. Anal. 27, 404–423 (1996)MathSciNetCrossRef
9.
go back to reference Demkowicz, L., Kurtz, J., Pardo, D., Paszyński, M., Rachowicz, W., Zdunek, A.: Computing with hp Finite Elements. II. Frontiers: Three-Dimensional Elliptic and Maxwell Problems with Applications. Chapman&Chall/CRC, Taylor&Francis Group Boca Raton, London, New York (2007). ISBN-13: 978-1584886723, ISBN-10: 1584886722 Demkowicz, L., Kurtz, J., Pardo, D., Paszyński, M., Rachowicz, W., Zdunek, A.: Computing with hp Finite Elements. II. Frontiers: Three-Dimensional Elliptic and Maxwell Problems with Applications. Chapman&Chall/CRC, Taylor&Francis Group Boca Raton, London, New York (2007). ISBN-13: 978-1584886723, ISBN-10: 1584886722
10.
go back to reference Jansen, K.E., Whiting, C.H., Hulbert, G.M.: A generalized-\(\alpha \) method for integrating the filtered Navier-Stokes equations with a stabilized finite element method. Comput. Methods Appl. Mech. Eng. 190, 305–319 (2000)MathSciNetCrossRef Jansen, K.E., Whiting, C.H., Hulbert, G.M.: A generalized-\(\alpha \) method for integrating the filtered Navier-Stokes equations with a stabilized finite element method. Comput. Methods Appl. Mech. Eng. 190, 305–319 (2000)MathSciNetCrossRef
11.
go back to reference Woźniak, M., Smołka, M., Cortes, A., Paszyński, M., Schaefer, R.: Scalability of direct solver for non-stationary Cahn-Hilliard simulations with linearized time integration scheme. Procedia Comput. Sci. 80, 834–844 (2016)CrossRef Woźniak, M., Smołka, M., Cortes, A., Paszyński, M., Schaefer, R.: Scalability of direct solver for non-stationary Cahn-Hilliard simulations with linearized time integration scheme. Procedia Comput. Sci. 80, 834–844 (2016)CrossRef
12.
go back to reference Austin Cottrell, J., Hughes, T.J.R., Bazilevs, Y.: Isogeometric Analysis: Toward Integration of CAD and FEA. Wiley, Hoboken (2009) Austin Cottrell, J., Hughes, T.J.R., Bazilevs, Y.: Isogeometric Analysis: Toward Integration of CAD and FEA. Wiley, Hoboken (2009)
14.
go back to reference Balay, S., et al.: PETSc User Manual, Argonne National Laboratory ANL-95/11 - Revision 3.4 (2013) Balay, S., et al.: PETSc User Manual, Argonne National Laboratory ANL-95/11 - Revision 3.4 (2013)
15.
go back to reference Balay, S., Gropp, W.D., Curfman McInnes, L., Smith, B.F.: Efficient management of parallelism in Object Oriented Numerical Software Libraries. In: Arge, E., Bruaset, A.M., Langtangen, H.P. (eds.) Modern Software Tools in Scientific Computing. Birkhäuser, Boston (1997). https://doi.org/10.1007/978-1-4612-1986-6_8 Balay, S., Gropp, W.D., Curfman McInnes, L., Smith, B.F.: Efficient management of parallelism in Object Oriented Numerical Software Libraries. In: Arge, E., Bruaset, A.M., Langtangen, H.P. (eds.) Modern Software Tools in Scientific Computing. Birkhäuser, Boston (1997). https://​doi.​org/​10.​1007/​978-1-4612-1986-6_​8
16.
go back to reference Amestoy, P.R., Duff, I.S.: Multifrontal parallel distributed symmetric and unsymmetric solvers. Comput. Methods Appl. Mech. Eng. 184, 501–520 (2000)CrossRef Amestoy, P.R., Duff, I.S.: Multifrontal parallel distributed symmetric and unsymmetric solvers. Comput. Methods Appl. Mech. Eng. 184, 501–520 (2000)CrossRef
17.
go back to reference Amestoy, P.R., Duff, I.S., Koster, J., L’Excellent, J.Y.: A fully asynchronous multifrontal solver using distributed dynamic scheduling. SIAM J. Matrix Anal. Appl. 1(23), 15–41 (2001)MathSciNetCrossRef Amestoy, P.R., Duff, I.S., Koster, J., L’Excellent, J.Y.: A fully asynchronous multifrontal solver using distributed dynamic scheduling. SIAM J. Matrix Anal. Appl. 1(23), 15–41 (2001)MathSciNetCrossRef
18.
go back to reference Amestoy, P.R., Guermouche, A., L’Excellent, J.-Y., Pralet, S.: Hybrid scheduling for the parallel solution of linear systems. Comput. Methods Appl. Mech. Eng. 2(32), 136–156 (2001) Amestoy, P.R., Guermouche, A., L’Excellent, J.-Y., Pralet, S.: Hybrid scheduling for the parallel solution of linear systems. Comput. Methods Appl. Mech. Eng. 2(32), 136–156 (2001)
19.
go back to reference Li, X.S.: An overview of SuperLU: algorithms, implementation, and user interface. TOMS Trans. Math. Softw. 31(3), 302–325 (2005)MathSciNetCrossRef Li, X.S.: An overview of SuperLU: algorithms, implementation, and user interface. TOMS Trans. Math. Softw. 31(3), 302–325 (2005)MathSciNetCrossRef
21.
go back to reference Hénon, P., Ramet, P., Roman, J.: PaStiX: a high-performance parallel direct solver for sparse symmetric definite systems. Parallel Comput. 28(2), 301–321 (2002)MathSciNetCrossRef Hénon, P., Ramet, P., Roman, J.: PaStiX: a high-performance parallel direct solver for sparse symmetric definite systems. Parallel Comput. 28(2), 301–321 (2002)MathSciNetCrossRef
23.
go back to reference Dzwinel, W., Kłusek, A., Paszyński, M.: A concept of a prognostic system for personalized anti-tumor therapy based on supermodeling. Procedia Comput. Sci. 108C, 1832–1841 (2017)CrossRef Dzwinel, W., Kłusek, A., Paszyński, M.: A concept of a prognostic system for personalized anti-tumor therapy based on supermodeling. Procedia Comput. Sci. 108C, 1832–1841 (2017)CrossRef
24.
go back to reference Dzwinel, W., Kłusek, A., Vasilyev, O.V.: Supermodeling in simulation of melanoma progression. Procedia Comput. Sci. 80, 999–1010 (2016)CrossRef Dzwinel, W., Kłusek, A., Vasilyev, O.V.: Supermodeling in simulation of melanoma progression. Procedia Comput. Sci. 80, 999–1010 (2016)CrossRef
25.
go back to reference Siwik, L., Łoś, M., Kłusek, A., Dzwinel, W., Paszyński, M., Pingali, K.: Supermodeling of tumor dynamics with parallel isogeometric analysis solver. arXiv:1912.12836 Siwik, L., Łoś, M., Kłusek, A., Dzwinel, W., Paszyński, M., Pingali, K.: Supermodeling of tumor dynamics with parallel isogeometric analysis solver. arXiv:​1912.​12836
26.
go back to reference Schaefer, R., Sȩdziwy, S.: Filtration in cohesive soils. Part II - Numerical approach, Computer Assisted Mechanics and Engineering Sciences (CAMES), vol. 6, pp. 15–26 (1999) Schaefer, R., Sȩdziwy, S.: Filtration in cohesive soils. Part II - Numerical approach, Computer Assisted Mechanics and Engineering Sciences (CAMES), vol. 6, pp. 15–26 (1999)
27.
go back to reference Schaefer, R., Sȩdziwy, S.: Filtration in cohesive soils. Part I - The mathematical model, Computer Assisted Mechanics and Engineering Sciences (CAMES), vol. 6, pp. 1–13 (1999) Schaefer, R., Sȩdziwy, S.: Filtration in cohesive soils. Part I - The mathematical model, Computer Assisted Mechanics and Engineering Sciences (CAMES), vol. 6, pp. 1–13 (1999)
Metadata
Title
A Three-Level Linearized Time Integration Scheme for Tumor Simulations with Cahn-Hilliard Equations
Authors
Maciej Smołka
Maciej Woźniak
Robert Schaefer
Copyright Year
2021
DOI
https://doi.org/10.1007/978-3-030-77980-1_14

Premium Partner