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2013 | OriginalPaper | Chapter

38. Acellular Hemoglobin-Based Oxygen Carrier Induced Vasoactivity: A Brief Review of Potential Pharmacologic Remedies

Authors : Hae Won Kim, Chi-Ming Hai, A. Gerson Greenburg

Published in: Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Publisher: Springer Berlin Heidelberg

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Abstract

Hemoglobin-based oxygen carriers (HBOCs) are currently in late phase clinical development as potential red blood cell substitutes. However, in recent clinical trials, most HBOC products have elicited vasoconstriction and blood pressure elevation. Mechanisms of the HBOC-mediated vasoactivity have not been fully elucidated. However, regardless of mechanisms involved, observations from preclinical and clinical studies indicate that the HBOC-mediated vasoconstriction/blood pressure elevation can be attenuated by conventional and newer anti-hypertensive agents and vasodilators. These include calcium channel blockers, nitrovasodilators, ACE inhibitors, selective PDE inhibitors and inhalation of gaseous NO or nebulized nitrites. There is little information available regarding the safety and effectiveness of these agents when used for treatment of HBOC-mediated vasoconstriction and BP elevation. In this review we identify some potentially useful pharmacologic agents and discuss potential issues involved in their use with HBOCs.

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previous chapter Vasoconstriction, Hypertension and Oxidative Toxicity are Regulated by Polymerized Hemoglobin Size

next chapter International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids–A White Paper

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Title: Acellular Hemoglobin-Based Oxygen Carrier Induced Vasoactivity: A Brief Review of Potential Pharmacologic Remedies
Authors: Hae Won Kim
Chi-Ming Hai
A. Gerson Greenburg
Publisher: Springer Berlin Heidelberg
Book: Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics
Print ISBN: 978-3-642-40716-1

Electronic ISBN: 978-3-642-40717-8

Copyright Year: 2013
DOI: https://doi.org/10.1007/978-3-642-40717-8_38

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