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Journal of Nanoparticle Research
Published in: Journal of Nanoparticle Research 1/2023

01-01-2023 | Research Paper

Acid-responsive drug-loaded copper phosphate nanoparticles for tumor cell therapy through synergistic apoptosis and ferroptosis strategy

Authors: Sheng Zhao, Liang He, Yihao Sun, Ting Xu, Chunmei Chen, Yi Ouyang, Yan Chen, Yixin Tan, Benqing Zhou, Hui Liu

Published in: Journal of Nanoparticle Research | Issue 1/2023

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Abstract

Synergistic apoptosis and ferroptosis strategy is quite promising for tumor treatment. Herein, a kind of polyacrylic acid-stabilized, carboxymethyl chitosan-coated, doxorubicin (DOX)-loaded copper phosphate nanoparticles (NPs) were prepared by a simple method for synergistic apoptosis and ferroptosis against tumor cells. The finally formed PAA-Cu3(PO4)2-DOX-CMCS (PCPDC) NPs displayed suitable hydrodynamic size (208.7 nm) and surface charge. When uptaken by tumor cells, they were degraded under acidic circumstances, releasing DOX and Cu2+ ions. The released Cu2+ ions reacted with glutathione (GSH) to produce Cu+ ions and deplete GSH. Through Cu+ ions-mediated Fenton-like reaction, H2O2 can be converted to hydroxyl radical to produce lipid hydroperoxides. Furthermore, the depleted GSH down-regulated the expression of glutathione peroxidase 4 (GPX4) protein, promoting the accumulation of lipid hydroperoxides to enhance ferroptosis. The released DOX can effectively induce apoptosis in tumor cells. These developed Cu3(PO4)2-based nanomaterials can kill tumor cells effectively through the synergistic apoptosis and ferroptosis strategy.
previous article Fabrication, structural, morphological, and optical studies of CdS:Cu nanostructured thin films: effect of Cu concentration
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Appendix
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Metadata
Title
Acid-responsive drug-loaded copper phosphate nanoparticles for tumor cell therapy through synergistic apoptosis and ferroptosis strategy
Authors
Sheng Zhao
Liang He
Yihao Sun
Ting Xu
Chunmei Chen
Yi Ouyang
Yan Chen
Yixin Tan
Benqing Zhou
Hui Liu
Publication date
01-01-2023
Publisher
Springer Netherlands
Published in
Journal of Nanoparticle Research / Issue 1/2023
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI
https://doi.org/10.1007/s11051-022-05655-5

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