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2018 | Book

Micro- and Nanotechnologies to Probe Brain Mechanobiology Read chapter Read first chapter

Acute and Chronic Neural Stimulation via Mechano-Sensitive Ion Channels

Author: Dr. Andy Kah Ping Tay

Publisher: Springer International Publishing

Book Series : Springer Theses

Part of: Springer Professional "Wirtschaft+Technik" , Springer Professional "Technik"

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About this book

This book describes the tools, developed by the author, for perturbing endogenous mechano-sensitive ion channels for magneto-mechanical neuro-modulation. He explores the ways in which these tools compare against existing ones such as electricity, chemicals, optogenetics, and techniques like thermos/magneto-genetics. The author also reports on two platforms—magnetic ratcheting and magnetic microfluidics for directed evolution and high throughput culture of magnetotactic bacteria—that produce high quality magnetic nanoparticles for biomedical applications like neural stimulations. This thesis was submitted to and approved by the University of California, Los Angeles.

Table of Contents

Frontmatter
Chapter 1. Micro- and Nanotechnologies to Probe Brain Mechanobiology
Abstract
In this chapter, I discuss the limitations of conventional tools for probing the mechano-biology of the brain and summarize published literature on micro- and nanotechnologies to investigate neural mechanobiology with greater spatiotemporal resolution.
Andy Kah Ping Tay
Chapter 2. Acute Neural Stimulation
Abstract
In the previous chapter, I discussed the advantages of using nanotechnologies to probe the mechano-biology of the brain. In this chapter, I describe the development of a magnetic microfabricated substrate and magnetic nanoparticle technology to induce calcium influx in neural networks by enhancing the opening probability of mechano-sensitive N-type Ca2+ channels.
Andy Kah Ping Tay
Chapter 3. Chronic Neural Stimulation
Abstract
In Chap. 2, I described the use of microfabricated magnetic substrate and magnetic nanoparticles for acute neural stimulation. Here, I explain how we employ the same tool for chronic magnetic stimulation for modulation of mechano-sensitive ion channel expression.
Andy Kah Ping Tay
Chapter 4. Phenotypic Selection of Magnetospirillum magneticum (AMB-1) Over-Producers Using Magnetic Ratcheting
Abstract
In the previous chapters, I highlighted the utility of magnetic nanoparticle (MNP)-based neural stimulation techniques. However, it is important to acknowledge the limitations of these techniques such as heterogeneity in MNP properties and our poor understanding of protein corona formation on MNPs. This chapter aims to tackle some of these limitations by generating magnetotactic bacteria over-producers as a source of high-quality MNPs.
Andy Kah Ping Tay
Chapter 5. Magnetic Microfluidic Separation for Estimating the Magnetic Contents of Magnetotactic Bacteria
Abstract
In Chap. 4, I described the use of magnetic ratcheting system. Nonetheless, the platform does not allow continuous enrichment of MTB over-producers in a long-term sterile condition. In this chapter, I detail the development of a magnetic microfluidic system that can overcome the limitations of magnetic ratcheting system.
Andy Kah Ping Tay
Chapter 6. Outlook for Magnetic Neural Stimulation Techniques
Abstract
In the previous chapters, I discussed the use of magnetic nanoparticle (MNP)-based technique for acute and chronic neural stimulation, followed by using magnetic ratcheting/magnetic microfluidic platforms for selecting magnetotactic bacteria over-producers for generating high-quality MNPs. Nonetheless, the uniformity of MNP properties is only one of the challenges to overcome to translate magnetic techniques for in vivo animal and clinical use. This chapter addresses the other challenges and proposes strategies to overcome them.
Andy Kah Ping Tay
Backmatter
Metadata
Title
Acute and Chronic Neural Stimulation via Mechano-Sensitive Ion Channels
Author
Dr. Andy Kah Ping Tay
Copyright Year
2018
Electronic ISBN
978-3-319-69059-9
Print ISBN
978-3-319-69058-2
DOI
https://doi.org/10.1007/978-3-319-69059-9