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2018 | OriginalPaper | Chapter

3. Alginate Microcapsules for Drug Delivery

Authors : Ainhoa Gonzalez-Pujana, Gorka Orive, Jose Luis Pedraz, Edorta Santos-Vizcaino, Rosa Maria Hernandez

Published in: Alginates and Their Biomedical Applications

Publisher: Springer Singapore

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Abstract

Currently, conventional drug delivery systems do not provide adequate therapeutic profiles for the management of multiple diseases. In this regard, cell encapsulation technology emerges as a suitable alternative. Undoubtedly, one of the most employed biomaterials for this purpose is alginate, since it presents multiple advantages that favor the development of this technology. Importantly, the thorough study concerning the purification and modification of the polymer has led to biocompatible alginates, a vital advancement for the correct function of the system. Furthermore, the possibility to entrap different cell types together with the plausibility of engineering cells to produce disparate therapeutic biomolecules has given rise to numerous applications. That is the case of relevant and prevalent diseases nowadays such as diabetes, cancer, or neurological diseases. Intensive research in the field has resulted in promising preclinical studies in animal models that have instigated the conduction of several clinical trials. Nonetheless, addressing some current challenges regarding aspects such as biosafety or biofunctionalization seems to be a prerequisite before the clinical translation.

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Title: Alginate Microcapsules for Drug Delivery
Authors: Ainhoa Gonzalez-Pujana
Gorka Orive
Jose Luis Pedraz
Edorta Santos-Vizcaino
Rosa Maria Hernandez
Publisher: Springer Singapore
Book: Alginates and Their Biomedical Applications
Print ISBN: 978-981-10-6909-3

Electronic ISBN: 978-981-10-6910-9

Copyright Year: 2018
DOI: https://doi.org/10.1007/978-981-10-6910-9_3

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