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Machine Learning for Streaming Data: Overview, Applications and Challenges Read chapter Read first chapter

2021 | OriginalPaper | Chapter

An Optimal Response-Adaptive Design for Multi-treatment Clinical Trials with Circular Responses

Authors : Taranga Mukherjee, Rahul Bhattacharya, Atanu Biswas

Published in: Applied Advanced Analytics

Publisher: Springer Singapore

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Abstract

Circular or directional outcomes are natural responses in many clinical trials (e.g. orthopedics, ophthalmology, sports medicine). Traditionally, clinical trials use equal allocation throughout the trial without utilizing the information contained in the sequentially observed responses in the running trial. Adaptive allocation designs are data-dependent alternatives to assign a greater number of subjects to the better performing treatments using the available data of the running trial in a convenient way. However, adaptive designs for circular responses are rare and, therefore, in the current work, we develop a multi-treatment response-adaptive randomization for circular treatment outcomes considering both the ethics and efficiency requirements. Apart from assessing the proposed allocation design empirically, the applicability of the design in real clinical trials is also enumerated from a practitioner’s viewpoint.

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previous chapter Implementing Learning Analytic Tools in Predicting Students’ Performance in a Business School
next chapter Stochastic Comparisons of Systems with Heterogeneous Log-Logistic Components
Literature
Atkinson, A. C., & Biswas, A. (2014). Randomised response-adaptive designs in clinical trials. Boca Raton: CRC Press.
Bakshi, P. (2010). Evaluation of various surgical techniques in Brunescent cataracts (Unpublished thesis). Disha Eye Hospital, India.
Basti, S., Vasavada, A. R., Thomas, R., & Padhmanabhan, P. (1993). Extracapsular cataract extraction: Surgical techniques. Indian Journal Ophthalmology, 41, 195–210.
Bazaraa, M., Sherali, H., & Shetty, C. M. (2006). Nonlinear programming: Theory and algorithms (3rd edn.). Chichester, London: Wiley.
Biswas, A., & Coad, D. S. (2005). A general multi-treatment adaptive design for multivariate responses. Sequential Analysis, 24, 139–158.CrossRef
Biswas, A., Dutta, S., Laha, A. K., & Bakshi, P. K. (2015). Response-adaptive allocation for circular data. Journal of Biopharmaceutical Statistics, 25, 830–842.CrossRef
Fisher, N. I. (1993). Statistical analysis of circular data. Cambridge: Cambridge University Press.
Hu, F., & Zhang, L. X. (2004). Asymptotic properties of doubly adaptive biased coin design for multi-treatment clinical trials. Annals of Statistics, 32, 268–301.CrossRef
Jain, N. B., Wilcox, III, R. B., & I. I. I., Katz, J. N., & Higgins, L. D., (2013). Clinical examination of the rotator cuff. PM & R, 5, 45–56.
Jammalamadaka, S. R., & SenGupta, A. (2001). Topics in circular statistics. Singapore: World Scientific.CrossRef
Mackool, R. J., & Brint, S. F. (2004). AquaLase: A new technology for cataract extraction. Current Opinion Ophthalmology, 15, 40–43.CrossRef
Mardia, K. V., & Jupp, P. E. (2004). Directional statistics. Chichester, London: Wiley.
Masket, S. (2004). The beginning of modern cataract surgery. The evaluation of small incision cataract surgery—A short history of ophthalmologists in progress. Cataract and Refractory Surgeries Today, 77–80.
Rosenberger, W. F., & Lachin, J. L. (2002). Randomisation in clinical trials: Theory and practice. New York: Wiley.
Silvey, S. (1980). Optimal designs: An introduction to the theory for parameter estimation. Springer Texts.
Metadata
Title
An Optimal Response-Adaptive Design for Multi-treatment Clinical Trials with Circular Responses
Authors
Taranga Mukherjee
Rahul Bhattacharya
Atanu Biswas
Copyright Year
2021
Publisher
Springer Singapore
Book
Applied Advanced Analytics

Print ISBN: 978-981-336-655-8

Electronic ISBN: 978-981-336-656-5

Copyright Year: 2021

DOI
https://doi.org/10.1007/978-981-33-6656-5_13