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2019 | OriginalPaper | Chapter

Analysis of Spontaneous EEG Activity in Alzheimer’s Disease Patients by Means of Multiscale Spectral Entropy

Authors : A. Maturana-Candelas, C. Gómez, J. Poza, S. J. Ruiz-Gómez, P. Núñez, M. Rodríguez, M. Figueruelo, C. Pita, N. Pinto, S. Martins, A. M. Lopes, I. Gomes, R. Hornero

Published in: Converging Clinical and Engineering Research on Neurorehabilitation III

Publisher: Springer International Publishing

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Abstract

The aim of this study was to analyze electroencephalographic (EEG) background activity in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) by means of multiscale spectral entropy (MSSE). To achieve this goal, five minutes of EEG activity were acquired from 18 cognitive healthy controls, 10 MCI subjects and 32 AD patients. Our results showed statistically significant differences (p-values < 0.05, Kruskal-Wallis test) in MSSE values for all scale factors. Additionally, a 3D receiver operating characteristic (ROC) curve was used to assess the discrimination ability of MSSE among the 3 groups, showing a good three-way discrimination power (volume under the surface of 0.6). These results suggest that MSSE can be a useful measure to characterize neural alterations in AD, even at early stages.

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previous chapter Characterizing Non-stationarity in Alzheimer’s Disease and Mild Cognitive Impairment by Means of Kullback-Leibler Divergence
next chapter Information-Theoretic Characterization of the Neural Mechanisms of Active Multisensory Decision Making
Literature
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Escudero, J., et al.: Analysis of electroencephalograms in Alzheimer’s disease patients with multiscale entropy. Physiol. Meas. 27(11), 1091–1106 (2006)CrossRef
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Poza, J., et al.: Extraction of spectral based measures from MEG background oscillations in Alzheimer’s disease. Med. Eng. Phys. 29, 1073–1083 (2007)CrossRef
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Abásolo, D., et al.: Entropy analysis of the EEG background activity in Alzheimer’s disease patients. Physiol. Meas. 27(3), 241–253 (2006)CrossRef
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Poza, J., et al.: Analysis of neural dynamics in mild cognitive impairment and Alzheimer’s disease using the wavelet turbulence. J. Neur. Eng. 11(2), 026010 (2014)CrossRef
Metadata
Title
Analysis of Spontaneous EEG Activity in Alzheimer’s Disease Patients by Means of Multiscale Spectral Entropy
Authors
A. Maturana-Candelas
C. Gómez
J. Poza
S. J. Ruiz-Gómez
P. Núñez
M. Rodríguez
M. Figueruelo
C. Pita
N. Pinto
S. Martins
A. M. Lopes
I. Gomes
R. Hornero
Copyright Year
2019
Book
Converging Clinical and Engineering Research on Neurorehabilitation III

Print ISBN: 978-3-030-01844-3

Electronic ISBN: 978-3-030-01845-0

Copyright Year: 2019

DOI
https://doi.org/10.1007/978-3-030-01845-0_116