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Published in:
The Cell–Surface Interaction Read chapter Read first chapter

2012 | OriginalPaper | Chapter

Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues

Authors : Margit Schulze, Edda Tobiasch

Published in: Tissue Engineering III: Cell - Surface Interactions for Tissue Culture

Publisher: Springer Berlin Heidelberg

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Abstract

Medicine was revolutionized in the last two centuries and its advances have more than doubled life expectancy. Nevertheless, some problems are as old as mankind and although the underlying causes might have changed, the problems themselves have not. Musculoskeletal disorders and tooth loss are such problems; they are the major reasons for the ever-growing need for bone replacement, which cannot always be realized by autologous material. New, multidisciplinary strategies are needed for the development of novel materials to meet the demand. Stem-cell-based approaches combined with newly designed scaffold materials seem to be promising tools for constructing tissue replacements. Human mesenchymal stem cells and their remarkable differentiation potential are an interesting cell source for the development of bio-engineered tissues. Scaffolds based on natural and synthetic materials with or without the use of bioactive molecules are constructed to mimic the natural environment. They can improve proliferation and differentiation of the scaffold-seeded cells. Combined, they can provide specific remedies for hard tissue replacement, which will be discussed in this chapter.

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previous chapter Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations
next chapter Bioactive Glass-Based Scaffolds for Bone Tissue Engineering
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Metadata
Title
Artificial Scaffolds and Mesenchymal Stem Cells for Hard Tissues
Authors
Margit Schulze
Edda Tobiasch
Copyright Year
2012
Publisher
Springer Berlin Heidelberg
Book
Tissue Engineering III: Cell - Surface Interactions for Tissue Culture

Print ISBN: 978-3-642-28281-2

Electronic ISBN: 978-3-642-28282-9

Copyright Year: 2012

DOI
https://doi.org/10.1007/10_2011_115

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