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Published in: Cellulose 3/2022

24-01-2022 | Original Research

Bacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation

Authors: Pedro B. Borba, Andréia Bagliotti Meneguin, Jhonatan Miguel Silva, Hernane da Silva Barud, Camila I. de Oliveira

Published in: Cellulose | Issue 3/2022

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Abstract

Bacterial nanocellulose (BNC) is a natural biopolymer produced by different strains of acetic acid bacteria. Biocompatibility, lack of immunogenicity, mechanical strength and crystallinity make BNC a highly applicable product for drug delivery and wound dressing. Previously, we demonstrated that diethylditiocarbamate (DETC), a Superoxide Dismutase 1 inhibitor, incorporated into BNC bio-curatives was effective for treating Cutaneous leishmaniasis (CL) lesions, a parasitic disease caused by Leishmania. We herein investigated the interactions between DETC and BNC. For this purpose, DETC was incorporated into BNC and thermal analysis, x-ray diffraction and Scanning electron microscopy were performed. Furthermore, in vitro DETC release and stability tests as well as degradation studies were also performed. Our results show that DETC is well incorporated into BNC, however it is short lived as suggested by degradation experiments. Future use of BNC DETC-based bio-curatives for the treatment of CL shall require further development in order to increase stability of DETC in the bio-curative.

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Appendix
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Literature
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Metadata
Title
Bacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation
Authors
Pedro B. Borba
Andréia Bagliotti Meneguin
Jhonatan Miguel Silva
Hernane da Silva Barud
Camila I. de Oliveira
Publication date
24-01-2022
Publisher
Springer Netherlands
Published in
Cellulose / Issue 3/2022
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI
https://doi.org/10.1007/s10570-021-04360-1