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2021 | OriginalPaper | Chapter

Bildgebungsbasiertes individuelles Design und additive Fertigung von osteochondralen Knochenersatzstrukturen

Authors: Philipp Sembdner, David Kilian, Dirk Hofmann, Stefan Holtzhausen, Tilman Ahlfeld, Anja Lode, Ralph Stelzer, Michael Gelinsky

Published in: Konstruktion für die Additive Fertigung 2020

Publisher: Springer Berlin Heidelberg

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Zusammenfassung

Design und Fertigung individueller, künstlicher Ersatzgewebe sind große Herausforderungen der biomedizinischen Forschung. Extrusionsbasierte additive Fertigungsmethoden eröffnen neue Möglichkeiten, um Biomaterialien nach einem individuellen Design anzuordnen. Der Schwerpunkt aktueller Forschungstätigkeiten liegt in der Generierung individueller biodegradierbarer Scaffolds sowie der Etablierung automatisierter Prozessketten zur Modellerstellung.
Am Beispiel des Kniegelenks wird der patientenindividuelle Ersatz von lädiertem Knochen- und Knorpelgewebe mit Mehrkomponenten-Strukturen dargestellt. Es kommt eine neue Methode der direkten Nutzung von Daten aus der Bildgebung (CT, MRT) im Modellierwerkzeug (CAD-System) zum Einsatz. Der Vorteil dieser Methode besteht im Berücksichtigen und der gezielten Darstellung aller Bildgebungsinformationen im Konstruktionsprozess, die sonst bei Segmentierung, Modellerstellung etc. verloren gehen.
Zur Vorbereitung der individuellen Modelldaten für den Mehrkomponenten-Druck werden entwickelte Softwaremethoden zur Bahngenerierung und Verarbeitung pastöser Materialien vorgestellt. Letztendlich erfolgt die Fertigung der zonalen Ersatzstruktur aus Knochenzement (CPC), welches den knöchernen Bereich ersetzt und einem Hydrogel, welches den Bereich des zu ersetzenden Knorpels abdeckt.
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Metadata
Title
Bildgebungsbasiertes individuelles Design und additive Fertigung von osteochondralen Knochenersatzstrukturen
Authors
Philipp Sembdner
David Kilian
Dirk Hofmann
Stefan Holtzhausen
Tilman Ahlfeld
Anja Lode
Ralph Stelzer
Michael Gelinsky
Copyright Year
2021
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-63030-3_2

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