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The Emperor’s New Body: Seeking for a Blueprint of Limb Regeneration in Humans Read chapter Read first chapter

2011 | OriginalPaper | Chapter

Bio-synthetic Encapsulation Systems for Organ Engineering: Focus on Diabetes

Authors : Rylie A. Green, Penny J. Martens, Robert Nordon, Laura A. Poole-Warren

Published in: Stem Cell Engineering

Publisher: Springer Berlin Heidelberg

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Abstract

The development of a safe and effective bio-synthetic encapsulation system will potentially improve the treatment of diseases known to benefit from cell implantation therapies. This is of particular importance in the progression towards a permanent treatment for type 1 diabetes. Cell-based therapies for insulin-dependent diabetics ultimately aim to eliminate the need for exogenous insulin through the implantation of donor islet cells or, alternately, stem cells differentiated into glucose-sensitive islet-like cells. Encapsulation devices are required to protect implanted cells from destructive host immune factors. A successful design will be bio-synthetic, having well-defined permeability and providing appropriate biomolecules for physiological functionality and survival of the encapsulated cells.

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previous chapter Stem Cells in Tissue Engineering and Cell Therapies of Urological Defects
next chapter Stem Cell Engineering for Regeneration of Bone Tissue
Literature
1.
Thanos CG, Emerich DF. On the use of hydrogels in cell encapsulation and tissue engineering systems. Recent Pat Drug Deliv Formul. 2008; 2(1):19–24.CrossRef
2.
Rother KI. Diabetes treatment – bridging the divide. N Engl J Med. 2007; 356(15):1499–1501.CrossRef
3.
Kabelitz D, et al. Toward cell-based therapy of type I diabetes. Trends Immunol. 2008; 29(2):68–74.CrossRef
4.
Alberti KGMM, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Geneva: Department of Noncommunicable Disease Surveillance, World Health Organisation; 1999.
5.
Anonymous. National diabetes statistics, 2007. Bethesda: U.S. Department of Health and Human Services. National Institute of Health; 2007, p. 23.
6.
American Diabetes Association. Economic costs of diabetes in the U.S. in 2007. Diabetes Care 2008; 31(3):596–615.CrossRef
7.
Pringle M, Houghton P. National service framework for diabetes: standards. London: Department of Health; 2001, p. 48.
8.
Pavlakis M, Khwaja K. Pancreas and islet cell transplantation in diabetes. Curr Opin Endocrinol Diabetes Obes. 2007; 14(2):146–150.CrossRef
9.
Pavlakis M, Khwaja K. Transplantation for type 1 diabetes: whole organ pancreas and islet cells. Curr Diabetes Rep. 2007; 6(6):473–478.CrossRef
10.
Naftanel MA. Pancreatic islet transplantation. PLoS Med. 2004; 1(3):198–201.CrossRef
11.
Yoon J-W, Jun H-S. Recent advances in insulin gene therapy for type 1 diabetes. Trends Mol Med. 2002; 8(2):62–68.CrossRef
12.
Laub O, Rutter WJ. Expression of the human insulin gene and cDNA in a heterologous mammalian system. J Biol Chem. 1983; 258:6043–6050.
13.
Iwata H, et al. Preparation of insulin-releasing Chinese Hamster ovary cell transfection of human insulin gene: its implantation into diabetic mice. In: Shalaby SW, et al., ed. Polymers of biological and biomedical significance. Washington: American Chemical Society; 1994.
14.
Falqui L, et al. Production of mature human insulin by retrovirally engineered fibroblasts and primary rat hepatocytes. Exp Clin Endocrinol Diabetes 1996; 104:A37.
15.
Bailey CJ, et al. Prospects for insulin delivery by ex-vivo somatic cell gene therapy. J Mol Med. 1999; 77:244–249.CrossRef
16.
Kofman AV, et al. Gene- and cell-based therapy of diabetes: between bench and bedside. Tsitologiia 2002; 44(12):1157–1177.MathSciNet
17.
Henquin J. Pancreatic b-cell mass or b-cell function? That is the question! Diabetes Obes Metab. 2008; 10(suppl 4):1–4.
18.
Shapiro AM, et al. International trial of the Edmonton protocol for islet transplantation. N Engl J Med. 2006; 355(13):1318–1330.CrossRef
19.
Ricordi C, Strom TB. Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol. 2004; 4:259–268.CrossRef
20.
Matsumoto S, et al. Efficacy of human islet isolation from the tail section of the pancreas for the possibility of living donor islet transplantation. Transplantation 2004; 78(6):839–843.CrossRef
21.
Ricordi C, et al. Detection of intrahepatic human islets following combined liver-islet allotransplantation. Pancreas 1992; 7(4):507–509.CrossRef
22.
Levy MM, et al. Intrathymic islet transplantation in the canine: I. Histological and functional evidence of autologous intrathymic islet engraftment and survival in pancreatectomized recipients. Transplantation 2002; 73(6):842–852.CrossRef
23.
Jaeger C, et al. Effect of transplantation site and culture pretreatment on islet xenograft survival (rat to mouse) in experimental diabetes without immunosuppression of the host. Acta Diabetol. 1994; 31(4):193–197.CrossRef
24.
Jaeger C, et al. Pancreatic islet xenografts at two different transplantation sites (renal subcapsular versus intraportal): comparison of graft survival and morphology. Exp Clin Endocrinol Diabetes 1995; 103(2):123–128.CrossRef
25.
Desai TA, et al. Nanoporous microsystems for islet cell replacement. Adv Drug Deliv Rev. 2004; 56(11):1661–1673.CrossRef
26.
Wilson JT, Chaikof EL. Challenges and emerging technologies in the immunoisolation of cells and tissues. Adv Drug Deliv Rev. 2008; 60(2):124–145.CrossRef
27.
Ricordi C, Edlund H. Toward a renewable source of pancreatic beta-cells. Nat Biotechnol. 2008; 26(4):397–398.CrossRef
28.
Williams PW. Notes on diabetes treated with extract and grafts of sheep’s pancreas. BMJ 1894; 2:1303–1304.
29.
Kobayashi T, et al. Indefinite islet protection from autoimmune destruction in nonobese diabetic mice by agarose microencapsulation without immunosuppression. Transplantation 2003; 75(5):619–625.CrossRef
30.
Schneider S, et al. Long-term graft function of adult rat and human islets encapsulated in novel alginate-based microcapsules after transplantation in immunocompetent diabetic mice. Diabetes 2005; 54(3):687–693.CrossRef
31.
Yang H, et al. Long-term function of fish islet xenografts in mice by alginate encapsulation. Transplantation 1997; 64(1):28–32.CrossRef
32.
Sun Y, et al. Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J Clin Invest. 1996; 98(6):1417–1422.CrossRef
33.
Elliott RB, et al. Intraperitoneal alginate-encapsulated neonatal porcine islets in a placebo-controlled study with 16 diabetic cynomolgus primates. Transplant Proc. 2005; 37(8): 3505–3508.CrossRef
34.
Serup P, et al. Science, medicine, and the future: islet and stem cell transplantation for treating diabetes. BMJ 2001; 322(7277):29–32.CrossRef
35.
Ballinger WF, Lacy PE. Transplantation of intact pancreatic islets in rats. Surgery 1972; 72:175–186.
36.
Ryan EA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54(7):2060–2070.CrossRef
37.
Calafiore R, et al. Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases. Diabetes Care 2006; 29(1):137–138.MathSciNetCrossRef
38.
Duvivier-Kali VF, et al. Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane. Diabetes 2001; 50(8):1698–1705.CrossRef
39.
Omer A, et al. Long-term normoglycemia in rats receiving transplants with encapsulated islets. Transplantation 2005; 79(1):52–58.CrossRef
40.
de Vos P, et al. Long-term biocompatibility, chemistry, and function of microencapsulated pancreatic islets. Biomaterials 2003; 24(2):305–312.MathSciNetCrossRef
41.
Tashiro H, et al. Characterization and transplantation of agarose encapsulated canine islets of Langerhans. Ann Transplant 1997; 2:33–39.
42.
Matsumoto S, et al. Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet 2005; 365(9471):1642–1644.
43.
Soria B, et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2001; 49:157–162.CrossRef
44.
Kroon E, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008; 26(4): 443–452.CrossRef
45.
Suen PM, Leung PS. Pancreatic stem cells: a glimmer of hope for diabetes? J Pancreas. 2005; 6(5):422–424.
46.
Ramiya VK, et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med. 2000; 6(3):278–282.CrossRef
47.
Seaberg RM, et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol. 2004; 22:1115–1124.CrossRef
48.
Hori Y, et al. Enrichment of putative pancreatic progenitor cells from mice by sorting for prominin1 (CD133) and PDGFR{beta}. Stem Cells 2008; 26(11)2912–2920.CrossRef
49.
Lacy PE, et al. Maintenance of normoglycemia in diabetic mice by subcutaneous xenografts of encapsulated islets. Science 1991; 254(5039):1782–1784.CrossRef
50.
Maria-Engler SS, et al. Microencapsulation and tissue engineering as an alternative treatment of diabetes. Braz J Med Biol Res. 2001; 34(6):691–697.CrossRef
51.
Kizilel S, et al. The bioartificial pancreas: progress and challenges. Diabetes Technol Ther. 2005; 7(6):968–985.CrossRef
52.
Williams DF. The Williams dictionary of biomaterials. Liverpool University Press, 1999, ISBN 0-85323-921-5.
53.
Silva AI, et al. An overview on the development of a bio-artificial pancreas as a treatment of insulin-dependent diabetes mellitus. Med Res Rev. 2006; 26(2):181–222.CrossRef
54.
Yang KC, et al. Chitosan/gelatin hydrogel as immunoisolative matrix for injectable bioartificial pancreas. Xenotransplantation 2008; 15(6):407–416.MATHCrossRef
55.
Lacik I. Polymer chemistry in diabetes treatment by encapsulated islets of Langerhans: review to 2006. Aust J Chem. 2006; 59(8):508–524.CrossRef
56.
Kulseng B, et al. Transplantation of alginate microcapsules: generation of antibodies against alginates and encapsulated porcine islet-like cell clusters. Transplantation 1999; 67(7): 978–984.CrossRef
57.
King A, et al. The effect of capsule composition in the reversal of hyperglycemi in diabetic mice transplanted with microencapsulated allogeneic islets. Diabetes Technol Ther. 2003; 5:653–663.CrossRef
58.
Xu B-Y, et al. Rapid destruction of encapsulated islet xenografts by NOD Mice is CD4-dependent and facilitated by b-cells: innate immunity and autoimmunity do not play significant roles. Transplantation 2005; 80(3):402–409.CrossRef
59.
Dembczynski R, Jankowski T. Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. J Biomater Sci Polym Ed. 2001; 12(9):1051–1058.CrossRef
60.
Stewart WW, Swaisgood HE. Characterization of calcium alginate pore diameter by size-exclusion chromatography using protein standards. Enzyme Microb Technol. 1993; 15(11):922–927.CrossRef
61.
Partap S, et al. Preparation and characterisation of controlled porosity alginate hydrogels made via a simultaneous micelle templating and internal gelation process. J Mater Sci. 2007; 42(10):3502–3507.CrossRef
62.
Chan AW, et al. Kinetic controlled synthesis of pH-responsive network alginate. Biomacromolecules 2008; 9(9):2536–2545.CrossRef
63.
Brissová M, et al. Evaluation of microcapsule permeability via inverse size exclusion chromatography. Anal Biochem. 1996; 242(1):104–111.CrossRef
64.
Bosco D, et al. Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin. Diabetes 2000; 49(2):233–243.CrossRef
65.
Kaido T, et al. Impact of defined matrix interactions on insulin production by cultured human {beta}-cells: effect on insulin content, secretion, and gene transcription. Diabetes 2006; 55(10):2723–2729.CrossRef
66.
Nikolova G, et al. The vascular basement membrane: a niche for insulin gene expression and [beta] cell proliferation. Dev Cell 2006; 10(3):397–405.CrossRef
67.
Weber LM, et al. The effects of cell-matrix interactions on encapsulated [beta]-cell function within hydrogels functionalized with matrix-derived adhesive peptides. Biomaterials 2007; 28(19):3004–3011.CrossRef
68.
Beck J, et al. Islet encapsulation: strategies to enhance islet cell functions. Tissue Eng. 2007; 13(3):589–599.CrossRef
69.
D’Amour KA, et al. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol. 2005; 23(12):1534–1541.CrossRef
70.
Taylor CJ, et al. Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 2005; 366(9502):2019–2025.CrossRef
71.
Robertson NJ, et al. Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance. Proc Natl Acad Sci USA. 2007; 104(52):20920–20925.CrossRef
72.
Gershengorn MC, et al. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 2004; 306(5705):2261–2264.CrossRef
73.
Takeda Y, et al. Protection of islet allografts transplanted together with Fas ligand expressing testicular allografts. Diabetologia 1998; 41(3):315–321.CrossRef
74.
Sanlioglu AD, et al. Molecular mechanisms of death ligand-mediated immune modulation: a gene therapy model to prolong islet survival in type 1 diabetes. J Cell Biochem. 2008; 104(3):710–720.CrossRef
75.
Jin Y, et al. Simultaneous stimulation of Fas-mediated apoptosis and blockade of costimulation prevent autoimmune diabetes in mice induced by multiple low-dose streptozotocin. Gene Ther. 2004; 11(12):982–991.CrossRef
76.
Petrovsky N, et al. The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice. Ann NY Acad Sci. 2002; 958:204–208.CrossRef
77.
Meyer T, et al. Extracellular matrix proteins in the porcine pancreas: a structural analysis for directed pancreatic islet isolation. Transplant Proc. 1998; 30(2):354–354.CrossRef
78.
Parnaud G, et al. Blockade of β1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat β-cells attached on extracellular matrix. Diabetes 2006; 55(5):1413–1420.CrossRef
79.
Knox S, et al. Not all perlecans are created equal: interactions with fibroblast growth factor (FGF) 2 and FGF receptors. J Biol Chem. 2002; 277(17):14657–14665.
Metadata
Title
Bio-synthetic Encapsulation Systems for Organ Engineering: Focus on Diabetes
Authors
Rylie A. Green
Penny J. Martens
Robert Nordon
Laura A. Poole-Warren
Copyright Year
2011
Publisher
Springer Berlin Heidelberg
Book
Stem Cell Engineering

Print ISBN: 978-3-642-11864-7

Electronic ISBN: 978-3-642-11865-4

Copyright Year: 2011

DOI
https://doi.org/10.1007/978-3-642-11865-4_16