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Biomaterial-Associated Infection: A Perspective from the Clinic Read chapter Read first chapter

2013 | OriginalPaper | Chapter

6. Biomaterial-Dependent Characteristics of the Foreign Body Response and S. epidermidis Biofilm Interactions

Authors : James M. Anderson, M.D., Ph.D., Jasmine D. Patel, Ph.D.

Published in: Biomaterials Associated Infection

Publisher: Springer New York

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Abstract

This chapter presents our efforts to develop a better mechanistic understanding of how biomaterial interactions with blood components lead to alteration of the basic pathophysiologic mechanisms, in particular, inflammation and the foreign body response, which increase the probability of bacterial interactions, colonization, biofilm formation, and infection. In particular, we present perspectives on mechanisms of S. epidermidis biofilm formation, the role of surface chemistry on biofilm formation, the role of bacterial slime production in device infections, the apoptosis of adherent polymorphonuclear leukocytes in the acute inflammatory response, neutrophil mobility and phagocytosis of bacteria on biomaterials, generation of reactive oxygen and nitrogen species by biomaterial-adherent neutrophils, and quorum sensing in S. epidermidis biofilm formation. Our work has focused on infection mechanisms of cardiovascular prostheses and devices where blood hemodynamics and shear stress play important roles in inflammatory cell interactions with biomaterial surfaces. However, we believe that much of our results also are applicable to static implant situations found in orthopedic, cosmetic (plastic), and other surgical areas.

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previous chapter Bridging the Gap Between In Vitro and In Vivo Evaluation of Biomaterial-Associated Infections
next chapter Dendritic Cell–Biomaterial Interactions: Implications for the Onset and Development of the Foreign Body Response
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Metadata
Title
Biomaterial-Dependent Characteristics of the Foreign Body Response and S. epidermidis Biofilm Interactions
Authors
James M. Anderson, M.D., Ph.D.
Jasmine D. Patel, Ph.D.
Copyright Year
2013
Publisher
Springer New York
Book
Biomaterials Associated Infection

Print ISBN: 978-1-4614-1030-0

Electronic ISBN: 978-1-4614-1031-7

Copyright Year: 2013

DOI
https://doi.org/10.1007/978-1-4614-1031-7_6

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