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2012 | OriginalPaper | Chapter

3. Biomedical Applications of Metal Oxide Nanoparticles

Authors: Silvana Andreescu, Maryna Ornatska, Joseph S. Erlichman, Ana Estevez, J. C. Leiter

Published in: Fine Particles in Medicine and Pharmacy

Publisher: Springer US

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Abstract

Metal oxide nanoparticles have a unique structure, interesting and unusual redox and catalytic properties, high surface area, good mechanical stability and are biocompatible. For these reasons, metal oxide nanoparticles have attracted considerable interest in the field of biomedical therapeutics, bio-imaging and biosensing. This chapter discusses properties and biomedical applications of selected nanometer size metal oxides. These materials have become important components in medical implants, cancer diagnosis and therapy and in neurochemical monitoring. For example, titania is the material of choice in medical implants; it provides an excellent biocompatible surface for cell attachment and proliferation. Ceria-based nanoparticles, on the other hand, have recently received a great deal of attention because of their redox, auto-catalytic and antioxidant properties. Several other metal oxides have been used as gas sensing nanoprobes for cell labeling and separation, as contrast agents for magnetic resonance imaging (MRI) and as carriers for targeted drug delivery. New and emerging applications of nanoceria as neuroprotective agents possessing antioxidant/free radical scavenging properties are emerging in the biomedical field, and ceria-based nanoparticles may be used as therapeutic agents in the treatment of medical diseases related to reactive oxygen species, such as spinal cord repair, stroke and degenerative retinal disorders. Issues related to biocompatibility and toxicity of these nanoparticles for in vivo biomedical applications remain to be fully explored.
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Metadata
Title
Biomedical Applications of Metal Oxide Nanoparticles
Authors
Silvana Andreescu
Maryna Ornatska
Joseph S. Erlichman
Ana Estevez
J. C. Leiter
Copyright Year
2012
Publisher
Springer US
DOI
https://doi.org/10.1007/978-1-4614-0379-1_3