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2017 | OriginalPaper | Chapter

25. Biomedical Sensing with the Atomic Force Microscope

Authors : Constanze Lamprecht, Jürgen Strasser, Melanie Koehler, Sandra Posch, Yoojin Oh, Rong Zhu, Lilia A. Chtcheglova, Andreas Ebner, Peter Hinterdorfer

Published in: Springer Handbook of Nanotechnology

Publisher: Springer Berlin Heidelberg

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Abstract

In this chapter we highlight the use and advantages of the atomic force microscope (AFM) in life science. Our aim is to present the wealth of experimental possibilities provided by this powerful toolbox with special regard to biomedical sensing applications. Originally invented in the 1980s to visualize solid surfaces on the nanometer scale, today AFM imaging is routinely used to nondestructively map the surface-ultrastructure of soft biological samples under physiological conditions with unprecedented lateral resolution. Owing to its force detection sensitivity that ranges from nano-Newtons down to a few pico-Newtons, the AFM has become an established technique for exploring kinetic and structural details of inter- and intramolecular interactions and biomolecular recognition processes. The combination of such single-molecule force measurements with topographical imaging has led to the development of recognition imaging, which allows for identification and mapping of specific components in complex biological samples with high spatial accuracy. In the following, the basic principles of biologically relevant AFM imaging modes, as well as the methods of single-molecule force spectroscopy (SMFS) and simultaneous topography and recognition imaging (TREC) will be introduced and discussed. Selected experiments will be presented in more detail to illustrate the combined application of these techniques in the elucidation of questions in molecular biology, pharmaceutical science and the medical field.

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Title: Biomedical Sensing with the Atomic Force Microscope
Authors: Constanze Lamprecht
Jürgen Strasser
Melanie Koehler
Sandra Posch
Yoojin Oh
Rong Zhu
Lilia A. Chtcheglova
Andreas Ebner
Peter Hinterdorfer
Publisher: Springer Berlin Heidelberg
Book: Springer Handbook of Nanotechnology
Print ISBN: 978-3-662-54355-9

Electronic ISBN: 978-3-662-54357-3

Copyright Year: 2017
DOI: https://doi.org/10.1007/978-3-662-54357-3_25