Top

Published in:

2018 | OriginalPaper | Chapter

9. Biosynthesis of 1,3-Propanediol: Genetics and Applications

Authors : Narisetty Vivek, Parameswaran Binod

Published in: Biosynthetic Technology and Environmental Challenges

Publisher: Springer Singapore

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Increased demand for renewable fuels and remarkable growth of biodiesel industry resulted in the accumulation of huge quantities of crude glycerol as the by-product. In the context of utilizing this by-product as the raw material, various fine and bulk chemicals were synthesized, among them 1,3-propanediol gained more importance due to its flexible properties as a monomer. Understanding the microbial physiology and genetics with integrated knowledge on molecular tools and techniques helps in developing engineered biocatalysts for the synthesis of 1,3-propanediol in higher titers and productivity. The microbial production of 1,3-propanediol was reviewed in brief regarding, the chemical process and its limitations, glycerol dissimilation, genetics of dha regulon in various microorganisms, metabolic engineering approaches to improve glycerol utilization for 1,3-PDO production, new strategies in modes of fermentation along with the future prospective was outlined.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

previous chapter Bioprocesses for the Production of 2,5-Furandicarboxylic Acid

next chapter Biosynthesis and Technological Advancements of Biosurfactants

Abbad-Andaloussi S, Manginot-Durr C, Amine J, Petitdemange E, Petitdemange H (1995) Isolation and characterization of clostridium butyricum DSM 5431 mutants with increased resistance to 1, 3-propanediol and altered production of acids. Appl Environ Microbiol 61(12):4413–4417

Ainala SK, Ashok S, Ko Y, Park S (2013) Glycerol assimilation and production of 1, 3-propanediol by Citrobacter amalonaticus Y19. Appl Microbiol Biotechnol 97(11):5001–5011

Anand P, Saxena R, Yadav S, Jahan F (2010) A greener solution for darker side of biodiesel: utilization of crude glycerol in 1, 3-propanediol production. J Biofuels 1(1):83–91

Anand P, Saxena RK, Marwah RG (2011) A novel downstream process for 1, 3-propanediol from glycerol-based fermentation. Appl Microbiol Biotechnol 90(4):1267–1276

Anggraini D (2014) Fermentation of glycerol from biodiesel waste to 1, 3-propanediol. Sriwijaya international seminar on energy-environmental science and technology, pp 143–148

Ashok S, Raj SM, Rathnasingh C, Park S (2011) Development of recombinant Klebsiella pneumoniae∆ dhaT strain for the co-production of 3-hydroxypropionic acid and 1, 3-propanediol from glycerol. Appl Microbiol Biotechnol 90(4):1253–1265

Avci FG, Huccetogullari D, Azbar N (2014) The effects of cell recycling on the production of 1, 3-propanediol by Klebsiella pneumoniae. Bioprocess Biosyst Eng 37(3):513–519

Baeza-Jiménez R, López-Martinez L, De la Cruz-Medina J, Espinosa-De-Los-Monteros J, Garcıa-Galindo H (2011) Effect of glucose on 1, 3-propanediol production by Lactobacillus reuteri efecto de la glucosa sobre la produccion de 1, 3-propanodiol por Lactobacillus reuteri. Revista Mexicana de Ingeniería Química 10(1):39–46

Barbirato F, Grivet JP, Soucaille P, Bories A (1996) 3-Hydroxypropionaldehyde, an inhibitory metabolite of glycerol fermentation to 1, 3-propanediol by enterobacterial species. Appl Environ Microbiol 62(4):1448–1451

Bhatia SK, Kurian JV (2008) Biological characterization of Sorona polymer from corn-derived 1, 3-propanediol. Biotech Lett 30(4):619–623

Biebl H (1991) Glycerol fermentation of 1, 3-propanediol by Clostridium butyricum. Measurement of product inhibition by use of a pH-auxostat. Appl Microbiol Biotechnol 35(6):701–705

Biebl H, Marten S (1995) Fermentation of glycerol to 1, 3-propanediol: use of cosubstrates. Appl Microbiol Biotechnol 44(1–2):15–19

Bizukojc M, Dietz D, Sun J, Zeng A-P (2010) Metabolic modelling of syntrophic-like growth of a 1, 3-propanediol producer, Clostridium butyricum, and a methanogenic archeon, Methanosarcina mazei, under anaerobic conditions. Bioprocess Biosyst Eng 33(4):507–523

Cao Y, Xia Q, Fang B (2006) Optimization of expression of dhaT gene encoding 1, 3-propanediol oxidoreductase from Klebsiella pneumoniae in Escherichia coli using the methods of uniform design and regression analysis. J Chem Technol Biotechnol 81(1):109–112

Celińska E (2010) Debottlenecking the 1, 3-propanediol pathway by metabolic engineering. Biotechnol Adv 28(4):519–530CrossRef

Celińska E (2012) Klebsiella spp. as a 1, 3-propanediol producer—the metabolic engineering approach. Crit Rev Biotechnol 32(3):274–288CrossRef

Celińska E, Drożdżyńska A, Jankowska M, Białas W, Czaczyk K, Grajek W (2015) Genetic engineering to improve 1, 3-propanediol production in an isolated Citrobacter freundii strain. Process Biochem 50(1):48–60

Chateau M, Dubois J-Y, Soucaille P (2016) Continuous culture for 1, 3-propanediol production using high glycerine concentration. US Patent 20,160,040,195

Chatzifragkou A, Dietz D, Komaitis M, Zeng AP, Papanikolaou S (2010) Effect of biodiesel-derived waste glycerol impurities on biomass and 1, 3-propanediol production of Clostridium butyricum VPI 1718. Biotechnol Bioeng 107(1):76–84

Chatzifragkou A, Aggelis G, Komaitis M, Zeng A-P, Papanikolaou S (2011) Impact of anaerobiosis strategy and bioreactor geometry on the biochemical response of Clostridium butyricum VPI 1718 during 1, 3-propanediol fermentation. Biores Technol 102(22):10625–10632

Chatzifragkou A, Aggelis G, Gardeli C, Galiotou-Panayotou M, Komaitis M, Papanikolaou S (2012) Adaptation dynamics of Clostridium butyricum in high 1, 3-propanediol content media. Appl Microbiol Biotechnol 95(6):1541–1552

Chatzifragkou A, Papanikolaou S, Kopsahelis N, Kachrimanidou V, Dorado MP, Koutinas AA (2014) Biorefinery development through utilization of biodiesel industry by-products as sole fermentation feedstock for 1, 3-propanediol production. Biores Technol 159:167–175

Chemicals R (2015) 1,3 propanediol (PDO) market analysis by application (Polytrimethylene Terephthalate (PTT), Polyurethane, Personal care & Detergents) and segment forecasts to 2022. Grand view research

Chen Z, Liu H, Liu D (2011) Metabolic pathway analysis of 1, 3-propanediol production with a genetically modified Klebsiella pneumoniae by overexpressing an endogenous NADPH-dependent alcohol dehydrogenase. Biochem Eng J 54(3):151–157

Cho M-H, Im Joen S, Pyo S-H, Mun S, Kim J-H (2006) A novel separation and purification process for 1, 3-propanediol. Process Biochem 41(3):739–744

Cui Y, Zhou J, Gao L, Zhu C, Jiang X, Fu S, Gong H (2014) Utilization of excess NADH in 2, 3-butanediol-deficient Klebsiella pneumoniae for 1, 3-propanediol production. J Appl Microbiol 117(3):690–698

Da Silva GP, Mack M, Contiero J (2009) Glycerol: a promising and abundant carbon source for industrial microbiology. Biotechnol Adv 27(1):30–39

Dabrock B, Bahl H, Gottschalk G (1992) Parameters affecting solvent production by Clostridium pasteurianum. Appl Environ Microbiol 58(4):1233–1239

Dabrowski S, Pietrewicz-Kubicz D, Zablotna E, Dlugolecka A (2012) 1, 3-propanediol production by Escherichia coli expressing genes of dha operon from Clostridium butyricum 2CR371. 5. Acta Biochim Pol 59(3):357

Dietz D, Zeng A-P (2014) Efficient production of 1, 3-propanediol from fermentation of crude glycerol with mixed cultures in a simple medium. Bioprocess Biosyst Eng 37(2):225–233

Drożdżyńska A, Pawlicka J, Kubiak P, Kośmider A, Pranke D, Olejnik-Schmidt A, Czaczyk K (2014) Conversion of glycerol to 1, 3-propanediol by Citrobacter freundii and Hafnia alvei–newly isolated strains from the Enterobacteriaceae. New Biotechnol 31(5):402–410CrossRef

Du C, Zhang Y, Li Y, Cao ZA (2007) Novel redox potential-based screening strategy for rapid isolation of Klebsiella pneumoniae mutants with enhanced 1, 3-propanediol-producing capability. Appl Environ Microbiol 73(14):4515–4521

Ferreira T, Ribeiro R, Ribeiro C, Freire D, Coelho M (2012) Evaluation of 1, 3-propanediol production from crude glycerol by Citrobacter freundii ATCC 8090. Chem Eng Trans 27:157–162

Ferreiraa TF, Saaba VDS, de Matosb PM, Maria C, Ribeiroc S, Coelhob MAZ (2014) Evaluation of 1, 3-propanediol production from glycerine by Clostridium butyricum NCIMB 8082. Chem Eng 38

Forsberg CW (1987) Production of 1, 3-propanediol from glycerol by Clostridium acetobutylicum and other Clostridium species. Appl Environ Microbiol 53(4):639–643

Galdeano-Villegas C, Santos VE, Zazo M, Garcia JL, Garcia-Ochoa F (2007) Fermentation of glycerol to 1,3-propanediol by Klebsiella oxytoca NRTL B-199: study of product inhibition. J Biotechnol 131:s102–s102

Gallardo R, Faria C, Rodrigues LR, Pereira MA, Alves MM (2014) Anaerobic granular sludge as a biocatalyst for 1, 3-propanediol production from glycerol in continuous bioreactors. Biores Technol 155:28–33

González K, Martin L, González A, Retegi A, Eceiza A, Gabilondo N (2017) D‐isosorbide and 1, 3‐propanediol as plasticizers for starch‐based films: characterization and aging study. J Appl Polym Sci 134(20)

Gonen C, Gungormusler M, Azbar N (2013) Continuous production of 1, 3-Propanediol using waste glycerol with clostridium beijerinckii NRRL B-593 immobilized on glass beads and glass rushing rings. Chem Biochem Eng Q 27(2):227–234

Grahame D (2013) Microbial production and characterization of 1, 3-pDO by a novel Lactobacillus panis strain

Hao J, Liu H, Liu D (2005) Novel route of reactive extraction to recover 1, 3-propanediol from a dilute aqueous solution. Ind Eng Chem Res 44(12):4380–4385

Hao J, Xu F, Liu H, Liu D (2006) Downstream processing of 1, 3-propanediol fermentation broth. J Chem Technol Biotechnol 81(1):102–108CrossRef

Hong E, Yoon S, Kim J, Kim E, Kim D, Rhie S, Ryu Y-W (2013) Isolation of microorganisms able to produce 1, 3-propanediol and optimization of medium constituents for Klebsiella pneumoniae AJ4. Bioprocess Biosyst Eng 36(6):835–843CrossRef

Jensen TØ, Kvist T, Mikkelsen MJ, Christensen PV, Westermann P (2012a) Fermentation of crude glycerol from biodiesel production by Clostridium pasteurianum. J Ind Microbiol Biotechnol 39(5):709–717CrossRef

Jensen TØ, Kvist T, Mikkelsen MJ, Westermann P (2012b) Production of 1, 3-pDO and butanol by a mutant strain of Clostridium pasteurianum with increased tolerance towards crude glycerol. AMB Express 2(1):1–7CrossRef

Jin LH, Lee J-H (2008) Change in proteomic profiles of genetically modified 1, 3-propanediol-producing recombinant E-coli. J Microbiol Biotech 18(8):1439–1444

Jin P, Lu S-G, Huang H, Luo F, Li S (2011a) Enhanced reducing equivalent generation for 1, 3-propanediol production through cofermentation of glycerol and xylose by Klebsiella pneumoniae. Appl Biochem Biotechnol 165(7–8):1532–1542CrossRef

Jin P, Li S, Lu S-G, Zhu J-G, Huang H (2011b) Improved 1, 3-propanediol production with hemicellulosic hydrolysates (corn straw) as cosubstrate: Impact of degradation products on Klebsiella pneumoniae growth and 1, 3-propanediol fermentation. Biores Technol 102:1815–1821CrossRef

Jun S-A, Moon C, Kang C-H, Kong SW, Sang B-I, Um Y (2010) Microbial fed-batch production of 1, 3-propanediol using raw glycerol with suspended and immobilized Klebsiella pneumoniae. Appl Biochem Biotechnol 161(1–8):491–501CrossRef

Kang TS, Korber DR, Tanaka T (2014a) Bioconversion of glycerol to 1, 3-propanediol in thin stillage-based media by engineered Lactobacillus panis PM1. J Ind Microbiol Biotechnol 41(4):629–635CrossRef

Kang TS, Korber DR, Tanaka T (2014b) Transcriptional repressor role of PocR on the 1, 3-propanediol biosynthetic pathway by Lactobacillus panis PM1. Biotech Lett 36(6):1263–1269CrossRef

Kaur G, Srivastava A, Chand S (2012) Advances in biotechnological production of 1, 3-propanediol. Biochem Eng J 64:106–118CrossRef

Kubiak P, Leja K, Myszka K, Celińska E, Spychała M, Szymanowska-Powałowska D, Czaczyk K, Grajek W (2012) Physiological predisposition of various Clostridium species to synthetize 1, 3-propanediol from glycerol. Process Biochem 47(9):1308–1319CrossRef

Lee S-M, Hong W-K, Heo S-Y, Park JM, Jung YR, Oh B-R, Joe M-H, Seo J-W, Kim CH (2014) Enhancement of 1, 3-propanediol production by expression of pyruvate decarboxylase and aldehyde dehydrogenase from Zymomonas mobilis in the acetolactate-synthase-deficient mutant of Klebsiella pneumoniae. J Ind Microbiol Biotechnol 41(8):1259–1266CrossRef

Li S, Tuan VA, Falconer JL, Noble RD (2001a) Effects of zeolite membrane structure on the separation of 1, 3-propanediol from glycerol and glucose by pervaporation. Chem Mater 13(5):1865–1873CrossRef

Li S, Tuan VA, Falconer JL, Noble RD (2001b) Separation of 1, 3-propanediol from aqueous solutions using pervaporation through an X-type zeolite membrane. Ind Eng Chem Res 40(8):1952–1959CrossRef

Li S, Tuan VA, Falconer JL, Noble RD (2001c) Separation of 1, 3-propanediol from glycerol and glucose using a ZSM-5 zeolite membrane. J Membr Sci 191(1):53–59CrossRef

Li L, Zhou S, Ji H, Gao R, Qin Q (2014) Optimization of fermentation conditions for 1, 3-propanediol production by marine Klebsiella pneumonia HSL4 using response surface methodology. Chin J Oceanol Limnol 32:1036–1045CrossRef

Liu H-J, Zhang D-J, Xu Y-H, Mu Y, Sun Y-Q, Xiu Z-L (2007) Microbial production of 1, 3-propanediol from glycerol by Klebsiella pneumoniae under micro-aerobic conditions up to a pilot scale. Biotech Lett 29(8):1281–1285CrossRef

Liu H, Ou X, Zhou S, Liu D (2010a) Microbial 1, 3-propanediol, its copolymerization with terephthalate, and applications. In: Plastics from bacteria, Springer, Berlin, pp. 405–425

Liu H, Xu Y, Zheng Z, Liu D (2010b) 1, 3-propanediol and its copolymers: research, development and industrialization. Biotechnol J 5(11):1137–1148CrossRef

Loureiro‐Pinto M, González‐Benito G, Coca M, Lucas S, García‐Cubero MT (2016a) Valorization of crude glycerol from the biodiesel industry to 1, 3‐propanediol by Clostridium butyricum DSM 10702: influence of pretreatment with ion exchange resins. Can J Chem Eng 94(7):1242–1248

Loureiro‐Pinto M, Coca M, González‐Benito G, Lucas S, García‐Cubero MT (2016b) Continuous bioproduction of 1, 3‐propanediol from biodiesel raw glycerol: operation with free and immobilized cells of Clostridium butyricum DSM 10702. Can J Chem Eng

Luerruk W, Shotipruk A, Tantayakom V, Prasitchoke P, Muangnapoh C (2009) Adsorption of 1, 3-propanediol from synthetic mixture using polymeric resin as adsorbents. Front Chem Eng China 3(1):52–57CrossRef

Luers F, Seyfried M, Daniel R, Gottschalk G (1997) Glycerol conversion to 1, 3-propanediol by Clostridium pasteurianum: cloning and expression of the gene encoding 1, 3-propanediol dehydrogenase. FEMS Microbiol Lett 154(2):337–345CrossRef

Ma Z, Rao Z, Xu L, Liao X, Fang H, Zhuge B, Zhuge J (2010) Expression of dha operon required for 1, 3-pD formation in Escherichia coli and Saccharomyces cerevisiae. Curr Microbiol 60(3):191–198CrossRef

Ma Z, Bian Y, Shentu X, Yu X (2013) Development of a novel recombinant strain Zygosaccharomyces rouxii JL2011 for 1, 3-propanediol production from glucose. Appl Microbiol Biotechnol 97(9):4055–4064CrossRef

Maervoet VE, Beauprez J, De Maeseneire SL, Soetaert WK, De Mey M (2012) Citrobacter werkmanii, a new candidate for the production of 1, 3-propanediol: strain selection and carbon source optimization. Green Chem 14(8):2168–2178CrossRef

Maervoet VE, De Maeseneire SL, Soetaert WK, De Mey M (2014) Unraveling the dha cluster in Citrobacter werkmanii: comparative genomic analysis of bacterial 1, 3-propanediol biosynthesis clusters. Bioprocess Biosyst Eng 37(4):711–718CrossRef

Malinowski JJ (1999) Evaluation of liquid extraction potentials for downstream separation of 1, 3-propanediol. Biotechnol Tech 13(2):127–130CrossRef

Malinowski JJ (2000) Reactive extraction for downstream separation of 1, 3-propanediol. Biotechnol Prog 16(1):76–79CrossRef

Markets MA (2015a) 1,3-propanediol (PDO) market by applications (PTT, Polyurethane, Cosmetic, Personal care & Home cleaning & Others) & geography—global market trends & forecasts to 2021. Marketsandmarkets

Markets RA (2015b) Global 1,3-propanediol (PDO) market 2015–2021. Research and markets, Dublin

Metsoviti M, Zeng A-P, Koutinas AA, Papanikolaou S (2013) Enhanced 1, 3-propanediol production by a newly isolated Citrobacter freundii strain cultivated on biodiesel-derived waste glycerol through sterile and non-sterile bioprocesses. J Biotechnol 163(4):408–418CrossRef

Nakamura CE, Whited GM (2003) Metabolic engineering for the microbial production of 1, 3-propanediol. Curr Opin Biotechnol 14(5):454–459CrossRef

Németh Á, Sevella B (2008) Development of a new bioprocess for production of 1, 3-propanediol I.: modeling of glycerol bioconversion to 1, 3-propanediol with Klebsiella pneumoniae enzymes. Appl Biochem Biotechnol 144(1):47–58CrossRef

Oh B-R, Seo J-W, Heo S-Y, Hong W-K, Luo LH, Son JH, Park D-H, Kim C-H (2012) Fermentation strategies for 1, 3-propanediol production from glycerol using a genetically engineered Klebsiella pneumoniae strain to eliminate by-product formation. Bioprocess Biosyst Eng 35(1–2):159–165CrossRef

Otte B, Grunwaldt E, Mahmoud O, Jennewein S (2009) Genome shuffling in Clostridium diolis DSM 15410 for improved 1, 3-propanediol production. Appl Environ Microbiol 75(24):7610–7616CrossRef

Petrov K, Stoyanov A (2012) Accelerated production of 1, 3-propanediol from glycerol by Klebsiella pneumoniae using the method of forced pH fluctuations. Bioprocess Biosyst Eng 35(3):317–321CrossRef

Pflügl S, Marx H, Mattanovich D, Sauer M (2012) 1, 3-propanediol production from glycerol with Lactobacillus diolivorans. Biores Technol 119:133–140CrossRef

Pflügl S, Marx H, Mattanovich D, Sauer M (2013) Genetic engineering of Lactobacillus diolivorans. FEMS Microbiol Lett 344(2):152–158CrossRef

Pflügl S, Marx H, Mattanovich D, Sauer M (2014) Heading for an economic industrial upgrading of crude glycerol from biodiesel production to 1, 3-propanediol by Lactobacillus diolivorans. Biores Technol 152:499–504CrossRef

Rao Z, Ma Z, Shen W, Fang H, Zhuge J, Wang X (2008) Engineered Saccharomyces cerevisiae that produces 1, 3-propanediol from d-glucose. J Appl Microbiol 105(6):1768–1776CrossRef

Raynaud C, Sarçabal P, Meynial-Salles I, Croux C, Soucaille P (2003) Molecular characterization of the 1, 3-propanediol (1, 3-pD) operon of Clostridium butyricum. Proc Natl Acad Sci 100(9):5010–5015CrossRef

Raynaud C, Lee J, Sarçabal P, Croux C, Meynial-Salles I, Soucaille P (2011) Molecular characterization of the glycerol-oxidative pathway of Clostridium butyricum VPI 1718. J Bacteriol 193(12):3127–3134CrossRef

Rukowicz B, Miesiąc I, Alejski K (2014) Separation of 1, 3-propanediol from aqueous solutions by ion exchange chromatography. Pol J Chem Technol 16(2):82–86CrossRef

Selembo PA, Perez JM, Lloyd WA, Logan BE (2009) Enhanced hydrogen and 1, 3-propanediol production from glycerol by fermentation using mixed cultures. Biotechnol Bioeng 104(6):1098–1106CrossRef

Skraly FA, Lytle BL, Cameron DC (1998) Construction and characterization of a 1, 3-propanediol operon. Appl Environ Microbiol 64(1):98–105

Stevens MJ, Vollenweider S, Meile L, Lacroix C (2011) 1, 3-propanediol dehydrogenases in Lactobacillus reuteri: impact on central metabolism and 3-hydroxypropionaldehyde production. Microb Cell Fact 10:61–69CrossRef

Tang X, Tan Y, Zhu H, Zhao K, Shen W (2009) Microbial conversion of glycerol to 1, 3-propanediol by an engineered strain of Escherichia coli. Appl Environ Microbiol 75(6):1628–1634CrossRef

Tao F, Tai C, Liu Z, Wang A, Wang Y, Li L, Gao C, Ma C, Xu P (2012) Genome sequence of Klebsiella pneumoniae LZ, a potential platform strain for 1, 3-propanediol production. J Bacteriol 194(16):4457–4458CrossRef

Tong I-T, Liao HH, Cameron D (1991) 1, 3-propanediol production by Escherichia coli expressing genes from the Klebsiella pneumoniae dha regulon. Appl Environ Microbiol 57(12):3541–3546

Umare S, Chandure A, Pandey R (2007) Synthesis, characterization and biodegradable studies of 1, 3-propanediol based polyesters. Polym Degrad Stab 92(3):464–479CrossRef

Urban RA, Bakshi BR (2009) 1, 3-propanediol from fossils versus biomass: a life cycle evaluation of emissions and ecological resources. Ind Eng Chem Res 48(17):8068–8082CrossRef

Vaidyanathan H, Kandasamy V, Ramakrishnan GG, Ramachandran K, Jayaraman G, Ramalingam S (2011) Glycerol conversion to 1, 3-propanediol is enhanced by the expression of a heterologous alcohol dehydrogenase gene in Lactobacillus reuteri. AMB Express 1(1):1–8CrossRef

Veiga-Da-Cunha M, Foster MA (1992) 1, 3-propanediol: NAD⁺ oxidoreductases of Lactobacillus brevis and Lactobacillus buchneri. Appl Environ Microbiol 58(6):2005–2010

Vivek N, Pandey A, Binod P (2016) Biological valorization of pure and crude glycerol into 1, 3-propanediol using a novel isolate Lactobacillus brevis N1E9. 3.3. Bioresour Technol

Vivek N, Christopher M, Kumar MK, Castro E, Binod P, Pandey A (2017a) Pentose rich acid pretreated liquor as co-substrate for 1, 3-propanediol production. Renew Energy

Vivek N, Sindhu R, Madhavan A, Anju AJ, Castro E, Faraco V, Pandey A, Binod P (2017b) Recent advances in the production of value added chemicals and lipids utilizing biodiesel industry generated crude glycerol as a substrate—metabolic aspects, challenges and possibilities: an overview. Bioresour Technol

Wang F, Qu H, Zhang D, Tian P, Tan T (2007) Production of 1, 3-propanediol from glycerol by recombinant E. coli using incompatible plasmids system. Mol Biotechnol 37(2):112–119CrossRef

Wang S, Dai H, Yan Z, Zhu C, Huang L, Fang B (2014) 1, 3-propanediol adsorption on a cation exchange resin: adsorption isotherm, thermodynamics, and mechanistic studies. Eng Life Sci 14(5):485–492CrossRef

Wilkens E, Ringel AK, Hortig D, Willke T, Vorlop K-D (2012) High-level production of 1, 3-propanediol from crude glycerol by Clostridium butyricum AKR102a. Appl Microbiol Biotechnol 93(3):1057–1063CrossRef

Wittlich P, Themann A, Vorlop K-D (2001) Conversion of glycerol to 1, 3-propanediol by a newly isolated thermophilic strain. Biotech Lett 23(6):463–466CrossRef

Wu Z, Wang Z, Wang G, Tan T (2013) Improved 1, 3-propanediol production by engineering the 2, 3-butanediol and formic acid pathways in integrative recombinant Klebsiella pneumoniae. J Biotechnol 168(2):194–200CrossRef

Xin B, Wang Y, Tao F, Li L, Ma C, Xu P (2016) Co-utilization of glycerol and lignocellulosic hydrolysates enhances anaerobic 1, 3-propanediol production by Clostridium diolis. Scientific reports, vol 6

Yang G, Tian J, Li J (2007) Fermentation of 1, 3-propanediol by a lactate deficient mutant of Klebsiella oxytoca under microaerobic conditions. Appl Microbiol Biotechnol 73(5):1017–1024CrossRef

Zeng A-P, Biebl H, Schlieker H, Deckwer W-D (1993) Pathway analysis of glycerol fermentation by Klebsiella pneumoniae: regulation of reducing equivalent balance and product formation. Enzyme Microbial Technol 15(9):770–779CrossRef

Zhang X, Li Y, Zhuge B, Tang X, Shen W, Rao Z, Fang H, Zhuge J (2006) Optimization of 1, 3-propanediol production by novel recombinant Escherichia coli using response surface methodology. J Chem Technol Biotechnol 81(6):1075–1078CrossRef

Zhang G, Ma B, Xu X, Li C, Wang L (2007) Fast conversion of glycerol to 1, 3-propanediol by a new strain of Klebsiella pneumoniae. Biochem Eng J 37(3):256–260CrossRef

Zhang G, Yang G, Wang X, Guo Q, Li Y, Li J (2012) Influence of blocking of 2, 3-butanediol pathway on glycerol metabolism for 1, 3-propanediol production by Klebsiella oxytoca. Appl Biochem Biotechnol 168(1):116–128

Zhou S, Li L, Perseke M, Huang Y, Wei J, Qin Q (2015) Isolation and characterization of a Klebsiella pneumoniae strain from mangrove sediment for efficient biosynthesis of 1, 3-propanediol. Sci Bull 60(5):511–521

Title: Biosynthesis of 1,3-Propanediol: Genetics and Applications
Authors: Narisetty Vivek
Parameswaran Binod
Publisher: Springer Singapore
Book: Biosynthetic Technology and Environmental Challenges
Print ISBN: 978-981-10-7433-2

Electronic ISBN: 978-981-10-7434-9

Copyright Year: 2018
DOI: https://doi.org/10.1007/978-981-10-7434-9_9

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Premium Partners