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Cognitive Neurodynamics

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20-11-2019 | Research Article

Bipolar oscillations between positive and negative mood states in a computational model of Basal Ganglia

Authors: Pragathi Priyadharsini Balasubramani, V. Srinivasa Chakravarthy

Published in: Cognitive Neurodynamics | Issue 2/2020

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Abstract

Bipolar disorder is characterized by mood swings—oscillations between manic and depressive states. The swings (oscillations) mark the length of an episode in a patient’s mood cycle (period), and can vary from hours to years. The proposed modeling study uses decision making framework to investigate the role of basal ganglia network in generating bipolar oscillations. In this model, the basal ganglia system performs a two-arm bandit task in which one of the arms (action responses) leads to a positive outcome, while the other leads to a negative outcome. We explore the dynamics of key reward and risk related parameters in the system while the model agent receives various outcomes. Particularly, we study the system using a model that represents the fast dynamics of decision making, and a module to capture the slow dynamics that describe the variation of some meta-parameters of fast dynamics over long time scales. The model is cast at three levels of abstraction: (1) a two-dimensional dynamical system model, that is a simple two variable model capable of showing bistability for rewarding and punitive outcomes; (2) a phenomenological basal ganglia model, to extend the implications from the reduced model to a cortico-basal ganglia setup; (3) a detailed network model of basal ganglia, that incorporates detailed cellular level models for a more realistic understanding. In healthy conditions, the model chooses positive action and avoids negative one, whereas under bipolar conditions, the model exhibits slow oscillations in its choice of positive or negative outcomes, reminiscent of bipolar oscillations. Phase-plane analyses on the simple reduced dynamical system with two variables reveal the essential parameters that generate pathological ‘bipolar-like’ oscillations. Phenomenological and network models of the basal ganglia extend that logic, and interpret bipolar oscillations in terms of the activity of dopaminergic and serotonergic projections on the cortico-basal ganglia network dynamics. The network’s dysfunction, specifically in terms of reward and risk sensitivity, is shown to be responsible for the pathological bipolar oscillations. The study proposes a computational model that explores the effects of impaired serotonergic neuromodulation on the dynamics of the cortico basal ganglia network, and relates this impairment to abstract mood states (manic and depressive episodes) and oscillations of bipolar disorder.

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Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12(10):366–375CrossRefPubMed

Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113(2):296–320. https://doi.org/10.1016/j.pharmthera.2006.08.004 CrossRefPubMed

Allen AT, Maher KN, Wani KA, Betts KE, Chase DL (2011) Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans. Genetics 188(3):579–590CrossRefPubMedPubMedCentral

Alloy LB, Abramson LY (2010) The role of the behavioral approach system (BAS) in bipolar spectrum disorders. Curr Dir Psychol Sci 19(3):189–194CrossRefPubMedPubMedCentral

Alloy LB, Nusslock R, Boland EM (2015) The development and course of bipolar spectrum disorders: an integrated reward and circadian rhythm dysregulation model. Annu Rev Clin Psychol 11:213CrossRefPubMedPubMedCentral

Amemori K, Gibb LG, Graybiel AM (2011) Shifting responsibly: the importance of striatal modularity to reinforcement learning in uncertain environments. Front Hum Neurosci 5:47. https://doi.org/10.3389/fnhum.2011.00047 CrossRefPubMedPubMedCentral

Balasubramani PP, Chakravarthy S, Ravindran B, Moustafa AA (2014) An extended reinforcement learning model of basal ganglia to understand the contributions of serotonin and dopamine in risk-based decision making, reward prediction, and punishment learning. Front Comput Neurosci 8:47CrossRefPubMedPubMedCentral

Balasubramani PP, Chakravarthy S, Ravindran B, Moustafa AA (2015a) A network model of basal ganglia for understanding the roles of dopamine and serotonin in reward–punishment–risk based decision making. Front Comput Neurosci 9:76CrossRefPubMedPubMedCentral

Balasubramani PP, Chakravarthy VS, Ali M, Ravindran B, Moustafa AA (2015b) Identifying the basal ganglia network model markers for medication-induced impulsivity in Parkinson’s Disease patients. PLoS ONE 10(6):e0127542CrossRefPubMedPubMedCentral

Balasubramani PP, Chakravarthy VS, Wong-Lin K, Wang DH, Cohen JY, Nakamura K, Moustafa AA (2017) Neural circuit models of the serotonergic system. In: Computational models of brain and behavior, pp 389–400

Balasubramani PP, Chakravarthy VS, Ravindran B, Moustafa AA (2018) Modeling Serotonin’s contributions to basal ganglia dynamics. In: Computational neuroscience models of the basal ganglia. Springer, pp 215–243

Bell DE (1995) Risk, return and utility. Manag Sci 41:23–30CrossRef

Berk M, Dodd S, Kauer-Sant’Anna M, Malhi G, Bourin M, Kapczinski F, Norman T (2007) Dopamine dysregulation syndrome: implications for a dopamine hypothesis of bipolar disorder. Acta Psychiatr Scand 116(s434):41–49CrossRef

Bertran-Gonzalez J, Bosch C, Maroteaux M, Matamales M, Herve D, Valjent E, Girault JA (2008) Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J Neurosci 28(22):5671–5685. https://doi.org/10.1523/JNEUROSCI.1039-08.2008 CrossRefPubMedPubMedCentral

Bertran-Gonzalez J, Hervé D, Girault J-A, Valjent E (2010) What is the degree of segregation between striatonigral and striatopallidal projections? Front Neuroanat 4:136CrossRefPubMedPubMedCentral

Bonsall MB, Wallace-Hadrill SM, Geddes JR, Goodwin GM, Holmes EA (2012) Nonlinear time-series approaches in characterizing mood stability and mood instability in bipolar disorder. Proc R Soc Lond B Biol Sci 279(1730):916–924CrossRef

Bonsall MB, Geddes JR, Goodwin GM, Holmes EA (2015) Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise. J R Soc Interface 12(112):20150670CrossRefPubMedPubMedCentral

Boureau YL, Dayan P (2011) Opponency revisited: competition and cooperation between dopamine and serotonin. Neuropsychopharmacology 36(1):74–97. https://doi.org/10.1038/npp.2010.151 CrossRefPubMed

Bronstein YL, Cummings JL (2001) Neurochemistry of frontal-subcortical circuits. In: Lichter DG, Cummings JL (Eds) Frontal-subcortical circuits in psychiatric and neurological disorders. Guilford Press, New York, pp 59–91

Calabresi P, Maj R, Pisani A, Mercuri NB, Bernardi G (1992) Long-term synaptic depression in the striatum: physiological and pharmacological characterization. J Neurosci 12(11):4224–4233CrossRefPubMedPubMedCentral

Calabresi P, Picconi B, Tozzi A, Ghiglieri V, Di Filippo M (2014) Direct and indirect pathways of basal ganglia: a critical reappraisal. Nat Neurosci 17(8):1022–1030CrossRefPubMed

Chakravarthy VS, Balasubramani PP (2013) Basal ganglia system as an engine for exploration. In: Jaeger D, Jung R (eds) Encyclopedia of computational neuroscience. Springer, Berlin

Chakravarthy VS, Balasubramani PP (2014) Basal ganglia system as an engine for exploration. Springer, BerlinCrossRef

Chakravarthy VS, Joseph D, Bapi RS (2010) What do the basal ganglia do? A modeling perspective. Biol Cybern 103(3):237–253. https://doi.org/10.1007/s00422-010-0401-y CrossRefPubMed

Challis C, Beck SG, Berton O (2014) Optogenetic modulation of descending prefrontocortical inputs to the dorsal raphe bidirectionally bias socio affective choices after social defeat. Front behav neurosci 8:43CrossRefPubMedPubMedCentral

Chandler RA, Wakeley J, Goodwin GM, Rogers RD (2009) Altered risk-aversion and risk-seeking behavior in bipolar disorder. Biol Psychiatry 66(9):840–846CrossRefPubMed

Chang J, Chen L, Luo F, Shi L-H, Woodward D (2002) Neuronal responses in the frontal cortico-basal ganglia system during delayed matching-to-sample task: ensemble recording in freely moving rats. Exp Brain Res 142(1):67–80CrossRefPubMed

Collins AG, Frank MJ (2014) Opponent actor learning (OpAL): modeling interactive effects of striatal dopamine on reinforcement learning and choice incentive. Psychol Rev 121(3):337CrossRefPubMed

Confalonieri S (2015) The casus irreducibilis in Cardano’s Ars Magna and De Regula Aliza. Arch Hist Exact Sci 69(3):257–289CrossRef

Cookson J (1985) The neuroendocrinology of mania. J Affect Disord 8(3):233–241CrossRefPubMed

Cools R, Robinson OJ, Sahakian B (2008) Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward prediction. Neuropsychopharmacology 33(9):2291–2299. https://doi.org/10.1038/sj.npp.1301598 CrossRefPubMed

Cools R, Nakamura K, Daw ND (2011) Serotonin and dopamine: unifying affective, activational, and decision functions. Neuropsychopharmacology 36(1):98–113CrossRefPubMed

Cummings JL (1993) Frontal-subcortical circuits and human behavior. Arch Neurol 50(8):873–880CrossRefPubMed

Czubenko M, Kowalczuk Z, Ordys A (2015) Autonomous driver based on an intelligent system of decision-making. Cognit Comput 7(5):569–581CrossRefPubMedPubMedCentral

d’Acremont M, Lu ZL, Li X, Van der Linden M, Bechara A (2009) Neural correlates of risk prediction error during reinforcement learning in humans. Neuroimage 47(4):1929–1939. https://doi.org/10.1016/j.neuroimage.2009.04.096 CrossRefPubMed

Dayan P, Huys QJ (2008) Serotonin, inhibition, and negative mood. PLoS Comput Biol 4(2):e4. https://doi.org/10.1371/journal.pcbi.0040004 CrossRefPubMedPubMedCentral

Deakin JW, Graeff FG (1991) 5-HT and mechanisms of defence. J Psychopharmacol 5(4):305–315CrossRefPubMed

Delgado PL, Miller HL, Salomon RM, Licinio J, Krystal JH, Moreno FA, Charney DS (1999) Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biol Psychiatry 46(2):212–220CrossRefPubMed

DeLong MR (1990) Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13(7):281–285CrossRefPubMed

Dremencov E, Newman ME, Kinor N, Blatman-Jan G, Schindler CJ, Overstreet DH, Yadid G (2005) Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment. Neuropharmacology 48(1):34–42CrossRefPubMed

Eberle-Wang K, Mikeladze Z, Uryu K, Chesselet MF (1997) Pattern of expression of the serotonin_2C receptor messenger RNA in the basal ganglia of adult rats. J Comp Neurology 384(2):233–247CrossRef

Eldar E, Rutledge RB, Dolan RJ, Niv Y (2016) Mood as representation of momentum. Trends Cognit Sci 20(1):15–24CrossRef

Frank MJ, Claus ED (2006) Anatomy of a decision: striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal. Psychol Rev 113(2):300CrossRefPubMed

Frank MJ, Seeberger LC, O’Reilly RC (2004) By carrot or by stick: cognitive reinforcement learning in parkinsonism. Science 306(5703):1940–1943. https://doi.org/10.1126/science.1102941 CrossRefPubMed

Gagnon D, Petryszyn S, Sanchez M, Bories C, Beaulieu J, De Koninck Y, Parent M (2017) Striatal neurons expressing D1 and D2 receptors are morphologically distinct and differently affected by dopamine denervation in mice. Sci Rep 7:41432CrossRefPubMedPubMedCentral

Geddes JR, Miklowitz DJ (2013) Treatment of bipolar disorder. The Lancet 381(9878):1672–1682CrossRef

Gillies A, Willshaw D, Li Z (2002) Subthalamic-pallidal interactions are critical in determining normal and abnormal functioning of the basal ganglia. Proc Biol Sci 269(1491):545–551. https://doi.org/10.1098/rspb.2001.1817 CrossRefPubMedPubMedCentral

Grossberg S (1984) Some normal and abnormal behavioral syndromes due to transmitter gating of opponent processes. Biol Psychiatry 19:1075–1118PubMed

Harvey AG (2008) Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. Am J Psychiatry 165(7):820–829CrossRefPubMed

Hasbi A, Fan T, Alijaniaram M, Nguyen T, Perreault ML, O’Dowd BF, George SR (2009) Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth. Proc Natl Acad Sci USA 106(50):21377–21382. https://doi.org/10.1073/pnas.0903676106 CrossRefPubMed

Hasbi A, O’Dowd BF, George SR (2010) Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms. Curr Opin Pharmacol 10(1):93–99. https://doi.org/10.1016/j.coph.2009.09.011 CrossRefPubMed

Hasbi A, O’Dowd BF, George SR (2011) Dopamine D1–D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance. Mol Brain 4:26. https://doi.org/10.1186/1756-6606-4-26 CrossRefPubMedPubMedCentral

Hausdorff JM, Cudkowicz ME, Firtion R, Wei JY, Goldberger AL (1998) Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson’s disease and Huntington’s disease. Mov Disord 13(3):428–437CrossRefPubMed

Hilty DM, Leamon MH, Lim RF, Kelly RH, Hales RE (2006) A review of bipolar disorder in adults. Psychiatry 3:43–55PubMed

Hirshfeld-Becker DR, Biederman J, Calltharp S, Rosenbaum ED, Faraone SV, Rosenbaum JF (2003) Behavioral inhibition and disinhibition as hypothesized precursors to psychopathology: implications for pediatric bipolar disorder. Biol Psychiatry 53(11):985–999CrossRefPubMed

Hou D, Wang C, Chen Y, Wang W, Du J (2017) Long-range temporal correlations of broadband EEG oscillations for depressed subjects following different hemispheric cerebral infarction. Cogn Neurodyn 11(6):529–538CrossRefPubMedPubMedCentral

Houk JC, Adams JL, Barto AG (1995) A model of how the basal ganglia generate and use neural signals that predict reinforcement. Models of information processing in the basal ganglia, 249–270

Houk JC, Bastianen C, Fansler D, Fishbach A, Fraser D, Reber PJ, Simo LS (2007) Action selection and refinement in subcortical loops through basal ganglia and cerebellum. Philos Trans R Soc Lond B Biol Sci 362(1485):1573–1583. https://doi.org/10.1098/rstb.2007.2063 CrossRefPubMedPubMedCentral

Hu B, Guo Y, Zou X, Dong J, Pan L, Yu M, Tang W (2018) Controlling mechanism of absence seizures by deep brain stimulus applied on subthalamic nucleus. Cogn Neurodyn 12(1):103–119CrossRefPubMed

Hu B, Diao X, Guo H, Deng S, Shi Y, Deng Y, Zong L (2019) The beta oscillation conditions in a simplified basal ganglia network. Cogn Neurodyn 13(2):201–217CrossRefPubMed

Humphries MD, Prescott TJ (2010) The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward. Prog Neurobiol 90(4):385–417. https://doi.org/10.1016/j.pneurobio.2009.11.003 CrossRefPubMed

Humphries MD, Lepora N, Wood R, Gurney K (2009) Capturing dopaminergic modulation and bimodal membrane behaviour of striatal medium spiny neurons in accurate, reduced models. Front Comput Neurosci 3:26CrossRefPubMedPubMedCentral

Huys QJ, Daw ND, Dayan P (2015) Depression: a decision-theoretic analysis. Annu Rev Neurosci 38:1–23CrossRefPubMed

Ingber L (2012) Computational algorithms derived from multiple scales of neocortical processing. Cogn Comput 4(1):38–50CrossRef

Izhikevich EM (2007) Dynamical systems in neuroscience. MIT Press, Cambridge

Izhikevich EM, FitzHugh R (2006) Fitzhugh-nagumo model. Scholarpedia 1(9):1349CrossRef

Jakab RL, Hazrati LN, Goldman-Rakic P (1996) Distribution and neurochemical character of substance P receptor (SPR)-immunoreactive striatal neurons of the macaque monkey: accumulation of SP fibers and SPR neurons and dendrites in “striocapsules” encircling striosomes. J Comp Neurol 369(1):137–149CrossRefPubMed

Jiang LH, Ashby CR Jr, Kasser RJ, Wang RY (1990) The effect of intraventricular administration of the 5-HT₃ receptor agonist 2-methylserotonin on the release of dopamine in the nucleus accumbens: an in vivo chronocoulometric study. Brain Res 513(1):156–160CrossRefPubMed

Joel D, Niv Y, Ruppin E (2002) Actor-critic models of the basal ganglia: new anatomical and computational perspectives. Neural Netw 15(4–6):535–547CrossRefPubMed

Kahneman D, Tversky A (1979) Prospect theory: an analysis of decision under risk. Econometrica 47:263–292CrossRef

Kalva SK, Rengaswamy M, Chakravarthy VS, Gupte N (2012) On the neural substrates for exploratory dynamics in basal ganglia: a model. Neural Netw 32:65–73. https://doi.org/10.1016/j.neunet.2012.02.031 CrossRefPubMed

Kanamaru T (2007) Van der Pol oscillator. Scholarpedia 2(1):2202CrossRef

Kim S-Y, Lim W (2019) Burst synchronization in a scale-free neuronal network with inhibitory spike-timing-dependent plasticity. Cogn Neurodyn 13(1):53–73CrossRefPubMed

Kranz G, Kasper S, Lanzenberger R (2010) Reward and the serotonergic system. Neuroscience 166(4):1023–1035CrossRefPubMed

Kreitzer AC (2009) Physiology and pharmacology of striatal neurons. Annu Rev Neurosci 32:127–147CrossRefPubMed

Krishnan R, Ratnadurai S, Subramanian D, Chakravarthy VS, Rengaswamy M (2011) Modeling the role of basal ganglia in saccade generation: is the indirect pathway the explorer? Neural Netw 24(8):801–813. https://doi.org/10.1016/j.neunet.2011.06.002 CrossRefPubMed

Lauwereyns J, Watanabe K, Coe B, Hikosaka O (2002) A neural correlate of response bias in monkey caudate nucleus. Nature 418(6896):413–417CrossRefPubMed

Lawrence NS, Williams AM, Surguladze S, Giampietro V, Brammer MJ, Andrew C, Phillips ML (2004) Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry 55(6):578–587CrossRefPubMed

Lennox B, Jacob R, Calder A, Lupson V, Bullmore E (2004) Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania. Psychol Med 34(5):795–802CrossRefPubMed

Leppänen JM (2006) Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr Opin Psychiatry 19(1):34–39CrossRefPubMed

Lichter DG, Cummings JL (2001) Frontal-subcortical circuits in psychiatric and neurological disorders. Guilford Press, New York

Liu X, Hairston J, Schrier M, Fan J (2011) Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies. Neurosci Biobehav Rev 35(5):1219–1236CrossRefPubMed

Long AB, Kuhn CM, Platt ML (2009) Serotonin shapes risky decision making in monkeys. Soc Cogn Affect Neurosci 4(4):346–356. https://doi.org/10.1093/scan/nsp020 CrossRefPubMedPubMedCentral

Mahmood T, Silverstone T (2001) Serotonin and bipolar disorder. J Affect Disord 66(1):1–11CrossRefPubMed

Markowitz H (1952) Portfolio selection. J Finance 7(1):77–91. https://doi.org/10.2307/2975974 CrossRef

McNab F, Klingberg T (2008) Prefrontal cortex and basal ganglia control access to working memory. Nat Neurosci 11(1):103CrossRefPubMed

Miguelez C, Morera-Herreras T, Torrecilla M, Ruiz-Ortega JA, Ugedo L (2014) Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson’s disease. Front Neural Circuits 8:21CrossRefPubMedPubMedCentral

Mink JW (1996) The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol 50(4):381CrossRefPubMed

Morita K, Morishima M, Sakai K, Kawaguchi Y (2012) Reinforcement learning: computing the temporal difference of values via distinct corticostriatal pathways. Trends Neurosci 35(8):457–467CrossRefPubMed

Moyer JT, Wolf JA, Finkel LH (2007) Effects of dopaminergic modulation on the integrative properties of the ventral striatal medium spiny neuron. J Neurophysiol 98(6):3731–3748CrossRefPubMed

Nadjar A, Brotchie JM, Guigoni C, Li Q, Zhou S-B, Wang G-J, Bezard E (2006) Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia. J Neurosci 26(34):8653–8661CrossRefPubMedPubMedCentral

Nakamura K (2013) The role of the dorsal raphé nucleus in reward-seeking behavior. Front Integr Neurosci 7:60CrossRefPubMedPubMedCentral

Nakamura K, Wong-Lin K (2014) Functions and computational principles of serotonergic and related systems at multiple scales. Front Integr Neurosci 8:23PubMedPubMedCentral

Nakamura T, Kiyono K, Wendt H, Abry P, Yamamoto Y (2016) Multiscale analysis of intensive longitudinal biomedical signals and its clinical applications. Proc IEEE 104(2):242–261CrossRef

Nambu A, Tokuno H, Takada M (2002) Functional significance of the cortico–subthalamo–pallidal ‘hyperdirect’ pathway. Neurosci Res 43(2):111–117CrossRefPubMed

Odgers CL, Mulvey EP, Skeem JL, Gardner W, Lidz CW, Schubert C (2009) Capturing the ebb and flow of psychiatric symptoms with dynamical systems models. Am J Psychiatry 166(5):575–582CrossRef

Perreault ML, Hasbi A, Alijaniaram M, Fan T, Varghese G, Fletcher PJ, George SR (2010) The dopamine D1–D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia. J Biol Chem 285(47):36625–36634. https://doi.org/10.1074/jbc.M110.159954 CrossRefPubMedPubMedCentral

Perreault ML, Hasbi A, O’Dowd BF, George SR (2011) The dopamine D1–D2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia. Front Neuroanat 5:31. https://doi.org/10.3389/fnana.2011.00031 CrossRefPubMedPubMedCentral

Phillips ML, Ladouceur CD, Drevets WC (2008) A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 13(9):833–857CrossRef

Price LH, Charney DS, Delgado PL, Heninger GR (1990) Lithium and serotonin function: implications for the serotonin hypothesis of depression. Psychopharmacology 100(1):3–12CrossRefPubMed

Rao AR (2018) An oscillatory neural network model that demonstrates the benefits of multisensory learning. Cogn Neurodyn 12(5):481–499CrossRefPubMedPubMedCentral

Redgrave P, Prescott TJ, Gurney K (1999) The basal ganglia: a vertebrate solution to the selection problem? Neuroscience 89(4):1009–1023CrossRefPubMed

Rogers RD (2011) The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. Neuropsychopharmacology 36(1):114–132. https://doi.org/10.1038/npp.2010.165 CrossRefPubMed

Rush AJ, Bernstein IH, Trivedi MH, Carmody TJ, Wisniewski S, Mundt JC, Nierenberg AA (2006) An evaluation of the quick inventory of depressive symptomatology and the Hamilton rating scale for depression: a sequenced treatment alternatives to relieve depression trial report. Biol Psychiatry 59(6):493–501CrossRefPubMed

Sarvestani IK, Lindahl M, Hellgren-Kotaleski J, Ekeberg Ö (2011) The arbitration–extension hypothesis: a hierarchical interpretation of the functional organization of the basal ganglia. Front Syst Neurosci 5:13CrossRef

Schultz W (1998) Predictive reward signal of dopamine neurons. J Neurophysiol 80(1):1–27CrossRefPubMed

Schultz W (2010) Dopamine signals for reward value and risk: basic and recent data. Behav Brain Funct 6:24. https://doi.org/10.1186/1744-9081-6-24 CrossRefPubMedPubMedCentral

Schultz W (2013) Updating dopamine reward signals. Curr Opin Neurobiol 23(2):229–238CrossRefPubMedPubMedCentral

Schultz W, Dayan P, Montague PR (1997) A neural substrate of prediction and reward. Science 275(5306):1593–1599CrossRefPubMed

Servan-Schreiber D, Printz H, Cohen JD (1990) A network model of catecholamine effects: gain, signal-to-noise ratio, and behavior. Science 249(4971):892–895CrossRefPubMed

Seymour B, Daw ND, Roiser JP, Dayan P, Dolan R (2012) Serotonin selectively modulates reward value in human decision-making. J Neurosci 32(17):5833–5842CrossRefPubMedPubMedCentral

Silverstone T (1985) Dopamine in manic depressive illness: a pharmacological synthesis. J Affect Disord 8(3):225–231CrossRefPubMed

Stauffer WR, Lak A, Schultz W (2014) Dopamine reward prediction error responses reflect marginal utility. Curr Biol 24(21):2491–2500CrossRefPubMedPubMedCentral

Sun R (2009) Motivational representations within a computational cognitive architecture. Cogn Comput 1(1):91–103CrossRef

Sun R (2017) Anatomy of the mind: a quick overview. Cogn Comput 9(1):1–4CrossRef

Suppes T, Dennehy EB, Gibbons EW (2000) The longitudinal course of bipolar disorder. J Clin Psychiatry 61(suppl 9):23–30PubMed

Surmeier DJ, Song WJ, Yan Z (1996) Coordinated expression of dopamine receptors in neostriatal medium spiny neurons. J Neurosci 16(20):6579–6591CrossRefPubMedPubMedCentral

Sutton RS, Barto AG (1998a) Reinforcement learning: an introduction. MIT Press, Cambridge

Sutton RS, Barto AG (1998b) Reinforcement learning: an introduction. Adaptive computations and machine learning. MIT Press, Bradford

Tanaka SC, Doya K, Okada G, Ueda K, Okamoto Y, Yamawaki S (2004) Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops. Nat Neurosci 7(8):887–893CrossRefPubMed

Tanaka SC, Samejima K, Okada G, Ueda K, Okamoto Y, Yamawaki S, Doya K (2006) Brain mechanism of reward prediction under predictable and unpredictable environmental dynamics. Neural Netw 19(8):1233–1241CrossRefPubMed

Tanaka SC, Schweighofer N, Asahi S, Shishida K, Okamoto Y, Yamawaki S, Doya K (2007) Serotonin differentially regulates short- and long-term prediction of rewards in the ventral and dorsal striatum. PLoS ONE 2(12):e1333. https://doi.org/10.1371/journal.pone.0001333 CrossRefPubMedPubMedCentral

Thakore JH, Keane VO, Dinan TG (1996) d-Fenfluramine-induced prolactin responses in mania: evidence for serotonergic subsensitivity. Am J Psychiatry 153(11):1460CrossRefPubMed

Thurley K, Senn W, Lüscher H-R (2008) Dopamine increases the gain of the input-output response of rat prefrontal pyramidal neurons. J Neurophysiol 99(6):2985–2997CrossRefPubMed

Urošević S, Abramson LY, Harmon-Jones E, Alloy LB (2008) Dysregulation of the behavioral approach system (BAS) in bipolar spectrum disorders: review of theory and evidence. Clin Psychol Rev 28(7):1188–1205CrossRefPubMedPubMedCentral

Wang W, Jiang Y, Cai E, Li B, Zhao Y, Zhu H, Gao Y (2019) L-menthol exhibits antidepressive-like effects mediated by the modification of 5-HTergic, GABAergic and DAergic systems. Cogn Neurodyn 13(2):191–200CrossRefPubMed

Ward RP, Dorsa DM (1996) Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. J Comp Neurol 370(3):405–414CrossRefPubMed

Weinberger M, Hutchison WD, Dostrovsky JO (2009) Pathological subthalamic nucleus oscillations in PD: can they be the cause of bradykinesia and akinesia? Exp Neurol 219(1):58–61CrossRefPubMed

Willshaw D, Li Z (2002) Subthalamic–pallidal interactions are critical in determining normal and abnormal functioning of the basal ganglia. Proc R Soc Lond B 269(1491):545–551CrossRef

Wood K (1985) The neurochemistry of mania: the effect of lithium on catecholamines, indoleamines and calcium mobilization. J Affect Disord 8(3):215–223CrossRefPubMed

Xie T, Li Q, Luo X, Tian L, Wang Z, Tan S et al (2019) Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia. Cogn Neurodyn 13(4):357–365CrossRef

Yahalom G, Simon ES, Thorne R, Peretz C, Giladi N (2004) Hand rhythmic tapping and timing in Parkinson’s disease. Parkinsonism Relat Disord 10(3):143–148. https://doi.org/10.1016/j.parkreldis.2003.10.001 CrossRefPubMed

Yatham LN (1996) Prolactin and cortisol responses to fenfluramine challenge in mania. Biol Psychiatry 39(4):285–288CrossRefPubMed

Yatham LN, Zis AP, Lam RW, Tam E, Shiah I-S (1997) Sumatriptan-induced growth hormone release in patients with major depression, mania, and normal controls. Neuropsychopharmacology 17(4):258CrossRefPubMed

Zeeman EC (1976) Catastrophe theory. Sci Am 234(4):65–83CrossRef

Title: Bipolar oscillations between positive and negative mood states in a computational model of Basal Ganglia
Authors: Pragathi Priyadharsini Balasubramani
V. Srinivasa Chakravarthy
Publication date: 20-11-2019
Publisher: Springer Netherlands
Published in: Cognitive Neurodynamics / Issue 2/2020
Print ISSN: 1871-4080
Electronic ISSN: 1871-4099
DOI: https://doi.org/10.1007/s11571-019-09564-7

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