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31-01-2021 | Original Research

Carbazate functionalized cellulose beads as potential scavengers specific for carbonylated proteins

Authors: Lanli Huang, Xiuqiong Zhou, Xianjing Feng, Jieou Nong, Guohua Yan, Li Zheng, Ming Gao

Published in: Cellulose | Issue 5/2021

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Abstract

Scavenging carbonylated proteins that are toxic substances inducing various diseases attract the most attention in the field of blood purification. In our study, functionalized cellulose beads modified by carbazate groups as affinity ligands of carbonyls were prepared for specific scavenging of carbonylated proteins based on the carbazate-aldehyde/ ketone reaction. Results showed that the carbazate-functionalized cellulose beads with different degrees of substitution (DS) maintained the original multi-porous structure with the diameter of about 50 μm and thermal stability. Spectroscopic and gel electrophoresis analysis indicated that the modified cellulose beads could effectively scavenge carbonylated proteins and the scavenging effects increased with the increase of DS. Thus, the carbazate functionalized cellulose beads may be developed as fillers in the column for the scavenging of carbonylated proteins.

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Title: Carbazate functionalized cellulose beads as potential scavengers specific for carbonylated proteins
Authors: Lanli Huang
Xiuqiong Zhou
Xianjing Feng
Jieou Nong
Guohua Yan
Li Zheng
Ming Gao
Publication date: 31-01-2021
Publisher: Springer Netherlands
Published in: Cellulose / Issue 5/2021
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-020-03659-9

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