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2014 | OriginalPaper | Chapter

82. Cardiac Hypertrophy-Specific Genes are Synergistic Activated by Myocardin and CREB-binding protein (CBP) p300

Authors : Zhenyu Wang, Xuehua Zhao, Mingzhe Li, Dongsun Cao, Tong-Cun Zhang

Published in: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Publisher: Springer Berlin Heidelberg

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Abstract

Myocardin is a remarkably potent transcriptional co-activator expressed in a broad range of embryonic and adult tissues, and it can induce cardiac hypertrophy. However, it remains poorly understood about the effects of myocardin in cardiac hypertrophy. Here, we show that the p300, a histone acetyltransferase, enhanced transcriptional activity of myocardin. Conversely, class II histone deacetylases HDAC5 suppress cardiac-special genes activation by myocardin and p300. These findings point that myocardin maybe a nexus for regulation of cardiac hypertrophic-special genes expression by changes in chromatin acetylation. Our results provide novel evidence to explore the roles of myocardin and their co-factors in cardiac hypertrophy for the future studies.

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Metadata
Title
Cardiac Hypertrophy-Specific Genes are Synergistic Activated by Myocardin and CREB-binding protein (CBP) p300
Authors
Zhenyu Wang
Xuehua Zhao
Mingzhe Li
Dongsun Cao
Tong-Cun Zhang
Copyright Year
2014
Publisher
Springer Berlin Heidelberg
Book
Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Print ISBN: 978-3-642-37921-5

Electronic ISBN: 978-3-642-37922-2

Copyright Year: 2014

DOI
https://doi.org/10.1007/978-3-642-37922-2_82

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