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Published in:
2017 | OriginalPaper | Chapter
Cell Patterning Method by Vibratory Stimuli
Authors : Ippei Tashiro, Masahiro Shimizu, Koh Hosoda
Published in: Biomimetic and Biohybrid Systems
Publisher: Springer International Publishing
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Abstract
Recently, micro robots driven by muscle cells attract a lot of attention. The shape of the robot can be controlled by modifying the growing of cells. This paper proposes a new cell patterning method by vibratory stimuli. The stimuli can detach redundant cells, and a certain cell pattern can be formed. In the experiment, around 80 Hz vibratory stimulus was applied to skeletal muscle cells via a PDMS scaffold and the cells were observed by camera. As a result, we found that a vibratory stimulus promotes detaching of the cells, especially at the moment of cell division. We also found that the increment of the cells depends on the vibratory energy. These results suggested that we can control the number of cells by vibration stimulus. Actually, we made specific cell pattern by the vibration stimulus.