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Published in: Polymer Bulletin 3/2018

29-06-2017 | Original Paper

Cellulose acetate butyrate bilayer coated microspheres for controlled release of ciprofloxacin

Authors: Keerti V. Phadke, Lata S. Manjeshwar, Tejraj M. Aminabhavi, M. P. Sathisha

Published in: Polymer Bulletin | Issue 3/2018

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Abstract

Novel non-toxic cellulose acetate butyrate (CAB) bilayer coated microspheres of gelatin (GE) prepared without using a cross-linker were used for investigating the controlled release of ciprofloxacin (CFX). The microspheres were characterized by Fourier transform infrared spectroscopy to understand CAB coating and its chemical inertness towards CFX. Differential scanning calorimetry was used to investigate the molecular level drug dispersion into the polymer matrix, while scanning electron microscopy was used to investigate the surface morphology of the formulated microspheres. Mean particle sizes ranged between 240 and 847 μm, while equilibrium water uptake performed in double distilled water ranged between 492 and 3152%. The drug loaded formulations exhibited high encapsulation efficiency up to 91%. The in vitro release studies performed in acidic and alkaline media indicated influence of GE and CFX content as well as amount of CAB coating on the release characteristics of CFX that was extended up to 20 h. Analysis of in vitro results using empirical equations suggested a non-Fickian release mechanism.
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Metadata
Title
Cellulose acetate butyrate bilayer coated microspheres for controlled release of ciprofloxacin
Authors
Keerti V. Phadke
Lata S. Manjeshwar
Tejraj M. Aminabhavi
M. P. Sathisha
Publication date
29-06-2017
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 3/2018
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-017-2092-1

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