Introduction
Cellulose structure
Source | Type | Degree of polymerization (range) | Reference(s) |
---|---|---|---|
Wood | Wood from various species | 6000–10,000 | Hallac and Ragauskas (2011) |
Wood pulp (in general) | 2000–4000 | ||
Wood CNF | 250–3500 | ||
Plant | Cotton | 10000–15,000 | |
Corn | 1700 | Xu et al. (2009) | |
Wheat straw | 2600 | Jahan and Mun (2009) | |
Jute | 1900 | Jahan and Mun (2009) | |
Bagasse | 1000 | Hallac and Ragauskas (2011) | |
Corn stover | 2500 | Hallac and Ragauskas (2011) | |
Corn kernel | 1700 | Hallac and Ragauskas (2011) | |
Bacteria | 7000–16,000 | ||
Algae | 2500–4300 | ||
Tunicate | 700–3500 |
Cellulose I, II, III, and IV
Cellulose sources
Wood and plant cellulose
Source | Type | Cellulose (wt.%) | Hemicellulose (wt.%) | Lignin (wt.%) | Reference(s) |
---|---|---|---|---|---|
Plant fibers (except cotton) | 30–75 | 10–35 | 0–20 | ||
Wood fibers | Softwood | 45–50 | 18–35 | 23–35 | Madsen and Gamstedt 2013 |
Hardwood | 40–50 | 24–40 | 18–25 |
Bacterial cellulose
Algal cellulose
Tunicate cellulose
Nanocellulose type | Source | Length (nm) | Width (nm) | Reference(s) |
---|---|---|---|---|
Nanofibril | Wood | >1000 | 2–100 | |
Plant | >1000 | 3–100 | ||
Bacteria | Different networks | 20–100 | Klemm et al. (2018) | |
Tunicate | >2000 | 10–30 | ||
CNC | Wood | 100–200 | 3–6 | |
Plant | 100–500 | 3–30 | ||
Bacteria | 100 − 1000 | 10 − 50 | ||
Algae | >1000 | 5–30 | ||
Tunicate | 100–2000 | 5–30 |
Various morphological forms of cellulosic particles
Cellulose fibers
Cellulose filaments
Cellulose micro/nanofibrils
Crystalline cellulose
Cellulosic particle types | Elastic modulus (GPa) | Tensile strength (MPa) | Elongation to rupture (%) | Reference(s) (Measurement or estimation techniques) |
---|---|---|---|---|
Plant fiber | 5–130 | 300–1050 | 1–8 | |
Wood pulp fiber | 14–40 | 380–1240 | 3–22 | |
Wood CNF | 14–84 | 1000–1300 | 4–8 | |
BC | 60–115 | – | – | |
Tunicate cellulose | 110–200 | – | – | Iwamoto et al. (2009) (AFM) |
CNC | 60–220 | 7500–7700 | – |
Cellulose properties
Cellulose solubility
Mechanical properties of cellulose
Hygroscopic properties of cellulose
Toxicity
Cellulose derivatives
Cellulose derivatives | Type | Specific functional group | Solvent | Major applications | Reference(s) |
---|---|---|---|---|---|
Cellulose ether | Methyl cellulose | –OH or –OCH3 | Cold water (< 50 °C), acetic acid | Food industry, tissue engineering | |
CMC | –OH or –OCH2COOH | Water | Tissue engineering, wound dressing, drug delivery, food industry, adsorption technologies, water-based paints, textile, paper industry | ||
Ethyl cellulose | –OH or –OCH2CH3 | Glycerol, propane-1,2-diol, H2O-insoluble | Paper industry, tissue engineering | ||
Hydroxy-ethyl cellulose | –OH or –OCH2CH2OH | Water | Cosmetic, cleaning solutions | ||
Hydroxy-propyl cellulose | –OH or –OCH2CH(OH)CH3 | Water | Tissue engineering, drug delivery, wound healing, sensor technologies | ||
Cellulose ester | Cellulose acetate | –OH or –O(C = O)CH3 | Acetone, acetic acid, dimethylacetamide | Separation industry, textile, tissue engineering, wound healing, drug delivery, food packaging | |
Cellulose nitrate | –OH or –ONO2 | Methanol, nitrobenzene, mixture of ethanol-ether | Separation industry, painting, coating, explosive materials | ||
Cellulose sulfate | –OH or –OSO3H | Water | Tissue engineering, drug delivery, cell immobilization/encapsulation |
Cellulose ether
Methyl cellulose
Carboxymethyl cellulose
Ethyl cellulose
Hydroxyethyl cellulose
Hydroxypropyl cellulose
Cellulose ester
Cellulose acetate
Cellulose nitrate
Cellulose sulfate
Cellulose in biomedical applications
Tissue engineering
Cellulose/cellulose derivatives | Type | Subtype | Major biomedical applications | Advantages and form for the specific application | Reference(s) |
---|---|---|---|---|---|
Cellulose | Micro/nano-crystalline cellulose | Tissue engineering | Films for in vitro cell culture and in vivo tissue regeneration | Petreus et al. (2014) | |
Interconnected highly porous hydrophobic and lipophilic scaffolds | Abraham et al. (2017) | ||||
Polymeric blends-based 3D-printed porous structure for biomimetic tissue engineering | Torres-Rendon et al. (2015) | ||||
Nanocomposite film with antibacterial activity | Pal et al. (2017) | ||||
Cellulose micro/nano-fibrils | Tissue engineering | Modified films with tailoring scaffold properties to regulate cell response | Courtenay et al. (2018) | ||
Surface modification of nanofiber scaffold for tissue engineering | Ye et al. (2017) | ||||
Coating 3D-printed scaffold with cellulose nanofibrils | Rashad et al. (2018) | ||||
Wound dressing | Crosslinked scaffold material with wound healing ability | Basu et al. (2018a) | |||
Increased epitheliali-zation of dressing-covered donor site | Hakkarainen et al. (2016) | ||||
Bacterial cellulose | Tissue engineering | Membranes for enhancing fibroblast growth and protein-free cell attachment | Birkheur et al. 2017 | ||
Hydrogel-based materials for bone tissue regeneration and implants | |||||
Membranes for engineering blood vessels | Bodin et al. (2007) | ||||
Layered scaffold for repair of osteochondral defects | Kumbhar et al. (2017) | ||||
Wound dressing | Suitable environment on-site as wound dressing materials | ||||
Significant epithelialization and regeneration of the skin | Lin et al. (2013) | ||||
Hydrogel microparticles as wound dressing material | Pandey et al. (2017) | ||||
Drug delivery | Transdermal drug delivery | Czaja et al. (2006) | |||
Tablet excipient | |||||
Cellulose derivatives | Cellulose ether | Methyl cellulose | Tissue engineering | Thermoresponsive hydrogel system in cell sheet engineering applications | Thirumala et al. (2013) |
Thermoresponsive with controllable crosslinking kinetics as scaffold material | Niemczyk-Soczynska et al. (2019) | ||||
Hydrogel ink as support for 3D plotting | Ahlfeld et al. (2018) | ||||
Wound dressing | Wound dressing hydrogel-based material | Suliwarno (2014) | |||
Carboxy-methyl cellulose | Tissue engineering | Stimulated adhesion, spreading, and migration of mouse fibroblasts | |||
Decreased osteoclastogenesis by murine bone marrow progenitors | Agis et al. (2010) | ||||
Hybrid hydrogel as composite materials for bone tissue engineering | Pasqui et al. (2014) | ||||
Wound dressing | Dissolvable foam dressing | Szczygielski et al. (2010) | |||
Films for controlling systemic infection and wound healing | Wong and Ramli (2014) | ||||
Dressing for burn wound with optimal moist environment around the wound | Ramli and Wong (2011) | ||||
Drug delivery | Extended drug release matrices | Palmer et al. (2011) | |||
Hydrogel complex for injectable and thermosensitive | Dai et al. (2017) | ||||
Hydrogel composite for controlled release polymeric drug system | Buhus et al. (2009) | ||||
Ethyl cellulose | Tissue engineering | Novel scaffold composite materials with nanofibrous/microp-orous structures | Hokmabad et al. (2019) | ||
Composite material for the development of biomimetic scaffolds for bone tissue engineering | Mao et al. (2018a) | ||||
Wound dressing | Nanofibers as potential wound dressing materials | Li et al. (2019a) | |||
Biocomposites with novel characteristics for infection free wound healing applications | Iqbal et al. (2015) | ||||
Drug delivery | Fiber blend with tunable drug release | Godakanda et al. (2019) | |||
Development of drug dosage forms with modified release | Wasilewska and Winnicka (2019) | ||||
Matrices for controlled drug delivery | Quadir et al. (2005) | ||||
Hydroxy-propyl methyl cellulose | Wound dressing | Biodegradable hydrogel composites for wound healing applications | Agubata et al. (2016) | ||
Composite hydrogel with wound healing effect | Bianchi et al. (2018) | ||||
Drug delivery | Composite material for enzyme-controlled colonic drug delivery system | Kshirsagar et al. 2011) | |||
Material for controlled drug release of gastroretentive floating drug delivery | Swain et al. (2009) | ||||
Cellulose ester | Cellulose acetated | Tissue engineering | Biofunctionalized nano scaffolds for heart valve tissue engineering | Chainoglou et al. (2016) | |
Composite biomimetic matrixes as scaffold for tissue engineering | Lukanina et al. (2018) | ||||
Crosslinked materials for the development of 3D fibrous network | Atila et al. (2016) | ||||
Wound dressing | Polymeric nanofibers with antimicrobial properties for wound healing applications | Teixeira et al. (2020) | |||
Polymeric blends as ECM mimicking nanofibrous wound dressing | |||||
Drug delivery | Nanofibers for drug delivery as patches through the skin | ||||
Development of topical and transdermal drug delivery system | Yu et al. (2013) | ||||
Cellulose sulfate | Tissue engineering | Highly biocompatible and bioactive cellulosic nanofiber networks | Palaninathan et al. (2018) | ||
Drug delivery | Development of microcapsule system composed of sodium cellulose sulfate (NaCS) and chitosan | Xie et al. (2009) |