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2021 | OriginalPaper | Chapter

Challenges and Materials in Artificial Organ Manufacturing

Authors : Sumit Budhiraja, Prerna Priya Ashok, K. Mathiyazhagan

Published in: Advances in Engineering Materials

Publisher: Springer Singapore

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Abstract

Additive manufacturing (AM), is also known as rapid prototyping, is considered as a revolution in field of manufacturing and fabrications and boosted the development in biomedical fabrication. The 3D printing technique is mostly utilized in the field of medical for the manufacturing of medical equipment and surgical equipment, especially 3D biomedical printing which means 3D printing of substance which are biologically compatible to human body, blood and cells in the field of tissue fabrications. The main aim of tissue fabrications and engineering is to produce the artificial organ which is functional and viable. To fulfill this objective, investigation of various manufacturing techniques and materials is required. The process is difficult as it includes multiple aspects of human physiology, like types of multiple cell culturing, vasculature, nerve innervation, and interactions with nearby cells. This paper objective is to find the suitable material, is difficult task and, need in-depth focus on why it is difficult & what are the factors influencing the negative role of effective utilization of 3D printing tissue engineering. Also, this paper focuses on comparative study of materials in economic perspective human organ manufacturing. At the end, the conclusion elaborates about the applications and challenges of additive manufacturing in medical field and the alternative materials for organ tissue manufacturing.

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Literature
1.
go back to reference Wang, X., Ao, Q., Tian, X., Fan, J., Tong, H., Hou, W., & Bai, S. (2017). Gelatin-Based hydrogels for organ 3D bioprinting. Polymers, 9(12), 401.CrossRef Wang, X., Ao, Q., Tian, X., Fan, J., Tong, H., Hou, W., & Bai, S. (2017). Gelatin-Based hydrogels for organ 3D bioprinting. Polymers, 9(12), 401.CrossRef
6.
go back to reference Wang, X., Yan, Y., & Zhang, R. (2010). Recent trends and challenges in complex organ manufacturing. Tissue Engineering Part B: Reviews, 16(2), 189–197.CrossRef Wang, X., Yan, Y., & Zhang, R. (2010). Recent trends and challenges in complex organ manufacturing. Tissue Engineering Part B: Reviews, 16(2), 189–197.CrossRef
8.
go back to reference Kalita, S. J. (2010). Rapid prototyping in biomedical engineering: structural intricacies of biological materials. Bio-integration of Medical Implant Materials, 349–397. Kalita, S. J. (2010). Rapid prototyping in biomedical engineering: structural intricacies of biological materials. Bio-integration of Medical Implant Materials, 349–397.
9.
go back to reference Rath, S. N., Pryymachuk, G., Bleiziffer, O. A., Lam, C. X. F., Arkudas, A., & Ho, S. T. B. (2011). Hyaluronan-based heparin-incorporated hydrogels for the generation of axially vascularized bioartificial bone tissues: In vitro and in vivo evaluation in a PLDLLA–TCP–PCL-composite system. Journal of Materials Science: Materials in Medicine, 22(5), 1279–1291. Rath, S. N., Pryymachuk, G., Bleiziffer, O. A., Lam, C. X. F., Arkudas, A., & Ho, S. T. B. (2011). Hyaluronan-based heparin-incorporated hydrogels for the generation of axially vascularized bioartificial bone tissues: In vitro and in vivo evaluation in a PLDLLA–TCP–PCL-composite system. Journal of Materials Science: Materials in Medicine, 22(5), 1279–1291.
10.
go back to reference Guvendiren, M., Lu, H. D., & Burdick, J. A. (2012). Shear-thinning hydrogels for biomedical applications. Soft Matter, 8(2), 260–272. Guvendiren, M., Lu, H. D., & Burdick, J. A. (2012). Shear-thinning hydrogels for biomedical applications. Soft Matter, 8(2), 260–272.
12.
go back to reference Marga, F., Jakab, K., Khatiwala, C., Shepherd, B., Dorfman, S., & Hubbard, B. (2012). Toward engineering functional organ modules by additive manufacturing. Biofabrication, 4(2), 022001.CrossRef Marga, F., Jakab, K., Khatiwala, C., Shepherd, B., Dorfman, S., & Hubbard, B. (2012). Toward engineering functional organ modules by additive manufacturing. Biofabrication, 4(2), 022001.CrossRef
13.
go back to reference IKADA, Y. (2001). Biocompatibility of hydrogels. Gels Handbook, 388–407. IKADA, Y. (2001). Biocompatibility of hydrogels. Gels Handbook, 388–407.
14.
go back to reference Zhu, J., Zhang, Y., Xu, N., Wang, L., Xiang, X., & Zhu, X. (2013). The preparation of PLL–GRGDS modified PTSG copolymer scaffolds and their effects on manufacturing artificial salivary gland. Journal of Biomaterials Science, Polymer Edition, 24(15), 1721–1739.CrossRef Zhu, J., Zhang, Y., Xu, N., Wang, L., Xiang, X., & Zhu, X. (2013). The preparation of PLL–GRGDS modified PTSG copolymer scaffolds and their effects on manufacturing artificial salivary gland. Journal of Biomaterials Science, Polymer Edition, 24(15), 1721–1739.CrossRef
15.
go back to reference Ahmed, E. M. (2015). Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research, 6(2), 105–121.CrossRef Ahmed, E. M. (2015). Hydrogel: Preparation, characterization, and applications: A review. Journal of Advanced Research, 6(2), 105–121.CrossRef
17.
go back to reference Li, Jianyu, Suo, Zhigang, & Vlassak, Joost J. (2014). Stiff, strong, and tough hydrogels with good chemical stability. Journal of Materials Chemistry B, 2(39), 6708–6713.CrossRef Li, Jianyu, Suo, Zhigang, & Vlassak, Joost J. (2014). Stiff, strong, and tough hydrogels with good chemical stability. Journal of Materials Chemistry B, 2(39), 6708–6713.CrossRef
18.
go back to reference Ahn, S. H., Lee, J., Park, S. A., & Kim, W. D. (2016). Three-dimensional bioprinting equipment technologies for tissue engineering and regenerative medicine. Tissue Engineering and Regenerative Medicine, 13(6), 663–676.CrossRef Ahn, S. H., Lee, J., Park, S. A., & Kim, W. D. (2016). Three-dimensional bioprinting equipment technologies for tissue engineering and regenerative medicine. Tissue Engineering and Regenerative Medicine, 13(6), 663–676.CrossRef
19.
go back to reference Park, S.-H., Jung, C. S., & Min, B.-H. (2016). Advances in three-dimensional bioprinting for hard tissue engineering. Tissue Engineering and Regenerative Medicine, 13(6), 622–635.CrossRef Park, S.-H., Jung, C. S., & Min, B.-H. (2016). Advances in three-dimensional bioprinting for hard tissue engineering. Tissue Engineering and Regenerative Medicine, 13(6), 622–635.CrossRef
20.
go back to reference Agarwala, S. (2016). A perspective on 3D bioprinting technology: Present and future. Journal of Engineering and Applied Science, 9(4), 931. Agarwala, S. (2016). A perspective on 3D bioprinting technology: Present and future. Journal of Engineering and Applied Science, 9(4), 931.
21.
go back to reference Zadpoor, A. A., & Malda, J. (2016). Additive manufacturing of biomaterials, tissues, and organs. Annals of Biomedical Engineering, 45(1), 1–11.CrossRef Zadpoor, A. A., & Malda, J. (2016). Additive manufacturing of biomaterials, tissues, and organs. Annals of Biomedical Engineering, 45(1), 1–11.CrossRef
22.
go back to reference Zhang, Y. S., Yue, K., Aleman, J., Mollazadeh-Moghaddam, K., Bakht, S. M., & Yang, J. (2016). 3D bioprinting for tissue and organ fabrication. Annals of Biomedical Engineering, 45(1), 148–163.CrossRef Zhang, Y. S., Yue, K., Aleman, J., Mollazadeh-Moghaddam, K., Bakht, S. M., & Yang, J. (2016). 3D bioprinting for tissue and organ fabrication. Annals of Biomedical Engineering, 45(1), 148–163.CrossRef
24.
go back to reference Ratheesh, G., Venugopal, J. R., Chinappan, A., Ezhilarasu, H., Sadiq, A., & Ramakrishna, S. (2017). 3D fabrication of polymeric scaffolds for regenerative therapy. ACS Biomaterials Science & Engineering, 3(7), 1175–1194.CrossRef Ratheesh, G., Venugopal, J. R., Chinappan, A., Ezhilarasu, H., Sadiq, A., & Ramakrishna, S. (2017). 3D fabrication of polymeric scaffolds for regenerative therapy. ACS Biomaterials Science & Engineering, 3(7), 1175–1194.CrossRef
25.
go back to reference Wu, D., Yu, Y., Tan, J., Huang, L., Luo, B., Lu, L. et al. (2018). 3D bioprinting of gellan gum and poly (ethylene glycol) diacrylate based hydrogels to produce human-scale constructs with high-fidelity. Materials & Design. Wu, D., Yu, Y., Tan, J., Huang, L., Luo, B., Lu, L. et al. (2018). 3D bioprinting of gellan gum and poly (ethylene glycol) diacrylate based hydrogels to produce human-scale constructs with high-fidelity. Materials & Design.
27.
go back to reference Gupta, S., Bissoyi, A., & Bit, A. (2018). A review on 3D printable techniques for tissue engineering. BioNanoScience. Gupta, S., Bissoyi, A., & Bit, A. (2018). A review on 3D printable techniques for tissue engineering. BioNanoScience.
28.
go back to reference Holzmeister, I., Schamel, M., Groll, J., Gbureck, U., & Vorndran, E. (2018). Artificial inorganic biohybrids: The functional combination of microorganisms and cells with inorganic materials. Acta Biomaterialia, 74, 17–35.CrossRef Holzmeister, I., Schamel, M., Groll, J., Gbureck, U., & Vorndran, E. (2018). Artificial inorganic biohybrids: The functional combination of microorganisms and cells with inorganic materials. Acta Biomaterialia, 74, 17–35.CrossRef
29.
go back to reference Macko, M., Szczepański, Z., Mikołajewski, D., Nowak, J., Mikołajewska, E., & Furtak, J. (2019). CAE/FDM methods for design and manufacture artificial organs for exercises purposes. Current Topics in Behavioral Neurosciences, 462–469. Macko, M., Szczepański, Z., Mikołajewski, D., Nowak, J., Mikołajewska, E., & Furtak, J. (2019). CAE/FDM methods for design and manufacture artificial organs for exercises purposes. Current Topics in Behavioral Neurosciences, 462–469.
30.
go back to reference Landers, R., & Mulhaupt, R. (2000). Desktop manufacturing of complex objects, prototypes and biomedical scaffolds utilizing computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers. Macromolecular Materials and Engineering, 282, 17–21.CrossRef Landers, R., & Mulhaupt, R. (2000). Desktop manufacturing of complex objects, prototypes and biomedical scaffolds utilizing computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers. Macromolecular Materials and Engineering, 282, 17–21.CrossRef
31.
go back to reference Deliormanlı, A. M. (2019). Direct Write Assembly of Graphene/Poly(ε-Caprolactone) Composite Scaffolds and Evaluation of Their Biological Performance Using Mouse Bone Marrow Mesenchymal Stem Cells. Applied Biochemistry and Biotechnology. Deliormanlı, A. M. (2019). Direct Write Assembly of Graphene/Poly(ε-Caprolactone) Composite Scaffolds and Evaluation of Their Biological Performance Using Mouse Bone Marrow Mesenchymal Stem Cells. Applied Biochemistry and Biotechnology.
33.
go back to reference Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2019). Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials, 119536. Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2019). Progress in 3D bioprinting technology for tissue/organ regenerative engineering. Biomaterials, 119536.
34.
go back to reference Kou, G., Ergu, D., Chen, Y., & Lin, C. (2016). Pairwise comparison matrix in multiple criteria decision making. Technological and Economic Development of Economy, 22(5), 738–765. Kou, G., Ergu, D., Chen, Y., & Lin, C. (2016). Pairwise comparison matrix in multiple criteria decision making. Technological and Economic Development of Economy, 22(5), 738–765.
Metadata
Title
Challenges and Materials in Artificial Organ Manufacturing
Authors
Sumit Budhiraja
Prerna Priya Ashok
K. Mathiyazhagan
Copyright Year
2021
Publisher
Springer Singapore
DOI
https://doi.org/10.1007/978-981-33-6029-7_59

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