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2019 | OriginalPaper | Chapter

Characterizing Non-stationarity in Alzheimer’s Disease and Mild Cognitive Impairment by Means of Kullback-Leibler Divergence

Authors : Pablo Núñez, Jesús Poza, Carlos Gómez, Víctor Rodríguez-González, Saúl José Ruiz-Gómez, Aarón Maturana-Candelas, Roberto Hornero

Published in: Converging Clinical and Engineering Research on Neurorehabilitation III

Publisher: Springer International Publishing

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Abstract

The aim of this study was to characterize the non-stationarity level of resting-state EEG in patients with dementia due to Alzheimer’s disease (AD), subjects with mild cognitive impairment (MCI) and healthy controls. A frequency-dependent implementation of the Kullback-Leibler divergence was used to characterize non-stationarity patterns. The results showed a statistically significant increase in non-stationarity for AD patients with respect to controls in the 1–70 Hz frequency range, as well as a less pronounced increase for MCI subjects with respect to controls. These results suggest that EEG activity during short time windows consists of more structured oscillations than that of AD patients or MCI subjects.

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Metadata
Title
Characterizing Non-stationarity in Alzheimer’s Disease and Mild Cognitive Impairment by Means of Kullback-Leibler Divergence
Authors
Pablo Núñez
Jesús Poza
Carlos Gómez
Víctor Rodríguez-González
Saúl José Ruiz-Gómez
Aarón Maturana-Candelas
Roberto Hornero
Copyright Year
2019
DOI
https://doi.org/10.1007/978-3-030-01845-0_115