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Published in: Cellulose 3/2022

27-01-2022 | Review Paper

Chitosan hydrogel, as a biological macromolecule-based drug delivery system for exosomes and microvesicles in regenerative medicine: a mini review

Authors: Lan Guo, Yali Guan, Peng Liu, Linghuan Gao, Zhifu Wang, Shengli Huang, Liang Peng, Zhiyu Zhao

Published in: Cellulose | Issue 3/2022

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Abstract

Extracellular vesicles are membrane-packed entities that are involved in various physiological and pathological processes. Recently, the role of exosomes and microvesicles in regenerative medicine has been elucidated. Indeed, therapeutic potential of stem cells may be partly due to exosomes or microvesicles. However, injection of these vesicles may lead to their rapid clearance from the injection site. To address this challenge, different delivery systems for these vesicles’ sustained delivery have been developed. In this regard, chitosan based hydrogels have been successfully utilized as delivery platforms for exosomes and microvesicles. In the current review, the prospects, challenges, and applications of chitosan-based hydrogels as a delivery vehicle for exosomes and microvesicles will be discussed.
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Literature
Ahsan SM, Thomas M, Reddy KK, Sooraparaju SG, Asthana A, Bhatnagar I (2018) Chitosan as biomaterial in drug delivery and tissue engineering. Int J Biol Macromol 110:97–109 PubMed
Akbari A et al (2020) Free and hydrogel encapsulated exosome-based therapies in regenerative medicine. Life Sci 249:117447 PubMed
Ali A, Ahmed S (2018) A review on chitosan and its nanocomposites in drug delivery. Int J Biol Macromol 109:273–286 PubMed
Antony R, Arun T, Manickam STD (2019) A review on applications of chitosan-based schiff bases. Int J Biol Macromol 129:615–633 PubMed
Aranaz I et al (2018) Cosmetics and cosmeceutical applications of chitin, chitosan and their derivatives. Polymers 10:213 PubMedCentral
Augustine R, Rehman SRU, Ahmed R, Zahid AA, Sharifi M, Falahati M, Hasan A (2020) Electrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing. Int J Biol Macromol 156:153–170 PubMed
Azoidis I, Cox SC, Davies OG (2018) The role of extracellular vesicles in biomineralisation: current perspective and application in regenerative medicine. J Tissue Eng 9:2041731418810130 PubMedPubMedCentral
Bailey AJ et al. (2021) MSC-derived extracellular vesicles to heal diabetic wounds: a systematic review and meta-analysis of preclinical animal studies, Stem Cell Rev Rep:1–12
Bakshi PS, Selvakumar D, Kadirvelu K, Kumar N (2020) Chitosan as an environment friendly biomaterial: a review on recent modifications and applications. Int J Biol Macromol 150:1072–1083 PubMed
Bellavia D et al (2018) Engineered exosomes: a new promise for the management of musculoskeletal diseases. Biochim Biophys Acta Gen Subj 1862:1893–1901 PubMed
Binu P, Mohan M (2021) Chitosan-based bionanocomposite in regenerative medicine. In: Bionanocomposites in J Tissue Eng Regen Med. Elsevier, pp 169–185
Bjørge I, Kim S, Mano J, Kalionis B, Chrzanowski W (2018) Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine–a new paradigm for tissue repair. Biomater Sci 6:60–78
Boido M, Ghibaudi M, Gentile P, Favaro E, Fusaro R, Tonda-Turo C (2019) Chitosan-based hydrogel to support the paracrine activity of mesenchymal stem cells in spinal cord injury treatment. Sci Rep 9:1–16
Brokesh AM, Gaharwar AK (2020) Inorganic biomaterials for regenerative medicine. ACS Appl Mater Interfaces 12:5319–5344 PubMed
Bruno S, Chiabotto G, Camussi G (2020) Extracellular vesicles: a therapeutic option for liver fibrosis. Int J Mol Sci 21:4255 PubMedCentral
Bu Y et al (2018) A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration. RSC Adv 8:10806–10817
Cabral J, Ryan AE, Griffin MD, Ritter T (2018) Extracellular vesicles as modulators of wound healing. Adv Drug Deliv Rev 129:394–406 PubMed
Casado-Díaz A, Quesada-Gómez JM, Dorado G (2020) Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: applications in skin wound healing. Front Bioeng Biotechnol 8:146 PubMedPubMedCentral
Cha H, Hong S, Park JH, Park HH (2020) Stem cell-derived exosomes and nanovesicles: promotion of cell proliferation, migration, and anti-senescence for treatment of wound damage and skin ageing. Pharmaceutics 12:1135 PubMedCentral
Chen K-H et al (2016) Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke. Oncotarget 7:74537 PubMedPubMedCentral
Chen CW et al (2018) Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction. Cardiovasc Res 114:1029–1040 PubMedPubMedCentral
Chen X et al (2019) Magnetic and self-healing chitosan-alginate hydrogel encapsulated gelatin microspheres via covalent cross-linking for drug delivery. Mater Sci Eng C 101:619–629
Cicciù M, Fiorillo L, Cervino G (2019) Chitosan use in dentistry: a systematic review of recent clinical studies. Mar Drugs 17:417 PubMedCentral
Cooper LF, Ravindran S, Huang C-C, Kang M (2020) A role for exosomes in craniofacial tissue engineering and regeneration. Front Physiol 10:1569 PubMedPubMedCentral
Dalirfardouei R, Gholoobi A, Vahabian M, Mahdipour E, Afzaljavan F (2021) Therapeutic role of extracellular vesicles derived from stem cells in cutaneous wound models a systematic review, Life Sci: 119271
De Jong OG et al (2019) Drug delivery with extracellular vesicles: from imagination to innovation. Acc Chem Res 52:1761–1770 PubMedPubMedCentral
Dimassi S, Tabary N, Chai F, Blanchemain N, Martel B (2018) Sulfonated and sulfated chitosan derivatives for biomedical applications: a review. Carbohydr Polym 202:382–396 PubMed
Duff S, Mafilios MS, Bhounsule P, Hasegawa JT (2019) The burden of critical limb ischemia: a review of recent literature. Vascu Health Risk Manage 15:187
Elkhenany H, Gupta S (2021) Mesenchymal stem cell–derived exosomes and regenerative medicine. In: Role of exosomes in biological communication systems. Springer, pp 141–164
Erol O, Pantula A, Liu W, Gracias DH (2019) Transformer hydrogels: a review. Adv Mater Technol 4:1900043
Farzamfar S et al (2019) Extracellular micro/nanovesicles rescue kidney from ischemia-reperfusion injury. J Cell Physiol 234:12290–12300 PubMed
Fu J, Yang F, Guo Z (2018) The chitosan hydrogels: from structure to function. New J Chem 42:17162–17180
Goradel NH, Jahangiri S, Negahdari B (2017) Effects of mesenchymal stem cell-derived exosomes on angiogenesis in regenerative medicine. Curr Regen Med Form: Recent Pat Regen Med 7:46–53
Goradel NH, Hour FG, Negahdari B, Malekshahi ZV, Hashemzehi M, Masoudifar A, Mirzaei H (2018) Stem cell therapy: a new therapeutic option for cardiovascular diseases. J Cell Biochem 119:95–104 PubMed
Gupta A, Kowalczuk M, Heaselgrave W, Britland ST, Martin C, Radecka I (2019) The production and application of hydrogels for wound management: a review. Eur Polym J 111:134–151
Guyot C, Cerruti M, Lerouge S (2021) Injectable, strong and bioadhesive catechol-chitosan hydrogels physically crosslinked using sodium bicarbonate. Mater Sci Eng C 118:111529
Hamedi H, Moradi S, Hudson SM, Tonelli AE (2018) Chitosan based hydrogels and their applications for drug delivery in wound dressings: a review. Carbohydr Polym 199:445–460 PubMed
Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J (2019) Mesenchymal stem cells for regenerative medicine. Cells 8:886 PubMedCentral
Hayashi H, Yamada M, Kumai J, Takagi N, Nomizu M (2018) Biological activities of laminin-111-derived peptide-chitosan matrices in a primary culture of rat cortical neurons. Arch Biochem Biophys 648:53–59 PubMed
Hoang HT, Jo S-H, Phan Q-T, Park H, Park S-H, Oh C-W, Lim KT (2021) Dual pH-/thermo-responsive chitosan-based hydrogels prepared using" click" chemistry for colon-targeted drug delivery applications. Carbohydr Polym 260:117812 PubMed
Islam MM, Shahruzzaman M, Biswas S, Sakib MN, Rashid TU (2020) Chitosan based bioactive materials in tissue engineering applications-a review. Bioact Mater 5:164–183 PubMedPubMedCentral
Jarrige M et al (2021) The future of regenerative medicine: cell therapy using pluripotent stem cells and acellular therapies based on extracellular vesicles. Cells 10:240 PubMedPubMedCentral
Jiang X, Lew K-S, Chen Q, Richards AM, Wang P (2018) Human mesenchymal stem cell-derived exosomes reduce ischemia/reperfusion injury by the inhibitions of apoptosis and autophagy. Curr Pharm Des 24:5334–5341 PubMed
Jiang S, Wang M, He J (2021) A review of biomimetic scaffolds for bone regeneration: toward a cell-free strategy. Bioeng Transl Med 6:e10206 PubMed
Jiang Z et al (2021) Construction of chitosan scaffolds with controllable microchannel for tissue engineering and regenerative medicine. Mater Sci Eng C 126:112178
Jin MC, Medress ZA, Azad TD, Doulames VM, Veeravagu A (2019) Stem cell therapies for acute spinal cord injury in humans: a review. Neurosurg Focus 46:E10 PubMed
Kalantari K, Afifi AM, Jahangirian H, Webster TJ (2019) Biomedical applications of chitosan electrospun nanofibers as a green polymer: review. Carbohydr Polym 207:588–600 PubMed
Keshtkar S, Azarpira N, Ghahremani MH (2018) Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine. Stem Cell Res Ther 9:1–9
Kildeeva N et al (2020) Influence of genipin crosslinking on the properties of chitosan-based films. Polymers 12:1086 PubMedCentral
Kou S, Peters L, Mucalo M (2020) Chitosan: a review of sources and preparation methods, Int J Biol Macromol
Lang X, Wang T, Sun M, Chen X, Liu Y (2020) Advances and applications of chitosan-based nanomaterials as oral delivery carriers: a review. Int J Biol Macromol 154:433–445 PubMed
Lavanya K, Chandran SV, Balagangadharan K, Selvamurugan N (2020) Temperature-and pH-responsive chitosan-based injectable hydrogels for bone tissue engineering. Mater Sci Eng C 111:110862
Li G, Xiao Q, Zhang L, Zhao Y, Yang Y (2017) Nerve growth factor loaded heparin/chitosan scaffolds for accelerating peripheral nerve regeneration. Carbohydr Polym 171:39–49 PubMed
Li X et al (2018) Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med 50:1–14 PubMedPubMedCentral
Liu Y, Hsu Y-H, Huang AP-H, Hsu S-h (2020) Semi-interpenetrating polymer network of hyaluronan and chitosan self-healing hydrogels for central nervous system repair. ACS Appl Mater Interfaces 12:40108–40120 PubMed
Luo Y, Teng Z, Wang X, Wang Q (2013) Development of carboxymethyl chitosan hydrogel beads in alcohol-aqueous binary solvent for nutrient delivery applications. Food Hydrocoll 31:332–339
Lv K et al (2019) Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics 9:7403 PubMedPubMedCentral
Mendt M, Rezvani K, Shpall E (2019) Mesenchymal stem cell-derived exosomes for clinical use. Bone Marrow Transplant 54:789–792 PubMed
Miguel SP, Moreira AF, Correia IJ (2019) Chitosan based-asymmetric membranes for wound healing: a review. Int J Biol Macromol 127:460–475 PubMed
Mohebbi S, Nezhad MN, Zarrintaj P, Jafari SH, Gholizadeh SS, Saeb MR, Mozafari M (2019) Chitosan in biomedical engineering: a critical review. Curr Stem Cell Res Ther 14:93–116 PubMed
Muiznieks LD (2018) Genipin cross-linking of elastin and elastin-based proteins. In: Protein scaffolds. Springer, pp 213–221
Nooshabadi VT et al (2020) Impact of exosome-loaded chitosan hydrogel in wound repair and layered dermal reconstitution in mice animal model. J Biomed Mater Res A 108:2138–2149 PubMed
O’Brien K, Breyne K, Ughetto S, Laurent LC, Breakefield XO (2020) RNA delivery by extracellular vesicles in mammalian cells and its applications. Nat Rev Mol Cell Biol 21:585–606 PubMedPubMedCentral
Peers S, Montembault A, Ladavière C (2020) Chitosan hydrogels for sustained drug delivery. J Control Release 326:150–163 PubMed
Pelizzo G et al (2018) Extracellular vesicles derived from mesenchymal cells: perspective treatment for cutaneous wound healing in pediatrics. Regen Med 13:385–394 PubMed
Popowski K, Lutz H, Hu S, George A, Dinh P-U, Cheng K (2020) Exosome therapeutics for lung regenerative medicine. J Extracell Vesicles 9:1785161 PubMedPubMedCentral
Potiwiput S et al (2020) Dual-crosslinked alginate/carboxymethyl chitosan hydrogel containing in situ synthesized calcium phosphate particles for drug delivery application. Mater Chem Phys 241:122354
Qing L, Chen H, Tang J, Jia X (2018) Exosomes and their microRNA cargo: new players in peripheral nerve regeneration. Neurorehabil Neural Repair 32:765–776 PubMedPubMedCentral
Qiu X et al (2020) Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis. Cell Prolif 53:e12830 PubMedPubMedCentral
Qu Y, Zhang Q, Cai X, Li F, Ma Z, Xu M, Lu L (2017) Exosomes derived from miR-181-5p-modified adipose-derived mesenchymal stem cells prevent liver fibrosis via autophagy activation. J Cell Mol Med 21:2491–2502 PubMedPubMedCentral
Rajabi M, McConnell M, Cabral J, Ali MA (2021) Chitosan hydrogels in 3D printing for biomedical applications, Carbohydr Polym, 117768
Ramasubramanian L, Kumar P, Wang A (2020) Engineering extracellular vesicles as nanotherapeutics for regenerative medicine. Biomolecules 10:48
Rani S, Ritter T (2016) The exosome: a naturally secreted nanoparticle and its application to wound healing. J Adv Mater 28:5542–5552
Ren X, Zhao M, Lash B, Martino MM, Julier Z (2020) Growth factor engineering strategies for regenerative medicine applications. Front Bioeng Biotechnol 7:469 PubMedPubMedCentral
Rong X, Liu J, Yao X, Jiang T, Wang Y, Xie F (2019) Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt/β-catenin pathway. Stem Cell Res Ther 10:1–11
Safdar R, Omar AA, Arunagiri A, Regupathi I, Thanabalan M (2019) Potential of chitosan and its derivatives for controlled drug release applications: a review. J Drug Deliv Sci Technol 49:642–659
Sahariah P, Masson M (2017) Antimicrobial chitosan and chitosan derivatives: a review of the structure–activity relationship. Biomacromol 18:3846–3868
Sahranavard M, Zamanian A, Ghorbani F, Shahrezaee MH (2020) A critical review on three dimensional-printed chitosan hydrogels for development of tissue engineering. Bioprinting 17:e00063
Shafei S et al (2020) Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: an in vivo study. J Biomed Mater Res A 108:545–556 PubMed
Shen Z, Kuang S, Zhang Y, Yang M, Qin W, Shi X, Lin Z (2020) Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism. Bioact Mater 5:1113–1126 PubMedPubMedCentral
Shi Q et al (2017) GMSC-derived exosomes combined with a chitosan/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model. Front Physiol 8:904 PubMedPubMedCentral
Skotland T, Sagini K, Sandvig K, Llorente A (2020) An emerging focus on lipids in extracellular vesicles. Adv Drug Deliv Rev 159:308–321 PubMed
Soundarya SP, Menon AH, Chandran SV, Selvamurugan N (2018) Bone tissue engineering: Scaffold preparation using chitosan and other biomaterials with different design and fabrication techniques. Int J Biol Macromol 119:1228–1239
Spicer CD (2020) Hydrogel scaffolds for tissue engineering: the importance of polymer choice. Polym Chem 11:184–219
Sultankulov B, Berillo D, Sultankulova K, Tokay T, Saparov A (2019) Progress in the development of chitosan-based biomaterials for tissue engineering and regenerative medicine. Biomolecules 9:470 PubMedCentral
Suvan J, Leira Y, Moreno Sancho FM, Graziani F, Derks J, Tomasi C (2020) Subgingival instrumentation for treatment of periodontitis. A systematic review. J Clin Periodontol 47:155–175 PubMed
Tang J et al (2020) Exosomes derived from mesenchymal stem cells protect the myocardium against ischemia/reperfusion injury through inhibiting pyroptosis. Drug Des Devel Ther 14:3765 PubMedPubMedCentral
Tang Y, Zhou Y, Li H-J (2021) Advances in mesenchymal stem cell exosomes: a review. Stem Cell Res Ther 12:1–12
Tao SC, Guo SC, Li M, Ke QF, Guo YP, Zhang CQ (2017) Chitosan wound dressings incorporating exosomes derived from microRNA-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full-thickness skin defects in a diabetic rat model. Stem Cells Transl Med 6:736–747 PubMed
Tsiapalis D, O’Driscoll L (2020) Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications. Cells 9:991 PubMedCentral
Tung SL et al (2020) Regulatory T cell extracellular vesicles modify T-effector cell cytokine production and protect against human skin allograft damage. Front Cell Dev Biol 8:317 PubMedPubMedCentral
Van den Broek LA, Boeriu CG (2019) Chitin and chitosan: properties and applications. John Wiley and Sons
Varlamov V, Il’ina A, Shagdarova BT, Lunkov A, Mysyakina I (2020) Chitin/chitosan and its derivatives: fundamental problems and practical approaches. Biochemistry (Moscow) 85:154–176
Vijayavenkataraman S (2020) Nerve guide conduits for peripheral nerve injury repair: a review on design, materials and fabrication methods. Acta Biomater 106:54–69 PubMed
Wang C et al (2020a) The fabrication of a highly efficient elf-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing. Biomater Sci 8:313–324
Wang L et al (2020) A new self-healing hydrogel containing hucMSC-Derived exosomes promotes bone regeneration. Front Bioeng Biotechnol 8:1047
Wang W, Meng Q, Li Q, Liu J, Zhou M, Jin Z, Zhao K (2020b) Chitosan derivatives and their application in biomedicine. Int J Mol Sci 21:487 PubMedCentral
Wang X et al (2021) Photothermally triggered biomimetic drug delivery of Teriparatide via reduced graphene oxide loaded chitosan hydrogel for osteoporotic bone regeneration. Chem Eng Sci 413:127413
Ways MT, Lau W, Khutoryanskiy V (2018) Chitosan and its derivatives for application in mucoadhesive 755 drug delivery systems. Polymers 10(3):267
Wenbo Q et al (2020) Controlled releasing of SDF-1α in chitosan-heparin hydrogel for endometrium injury healing in rat model. Int J Biol Macromol 143:163–172 PubMed
Witwer KW, Wolfram J (2021) Extracellular vesicles versus synthetic nanoparticles for drug delivery. Nat Rev Mater 6(2):103–106
Wong KL et al (2020) Intra-articular injections of mesenchymal stem cell exosomes and hyaluronic acid improve structural and mechanical properties of repaired cartilage in a rabbit model. Arthrosc: J Arthrosc Rel Sur 36:2215–2228
Wu J et al (2019) miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. Biomater 206:87–100
Wu X, Wang Y, Xiao Y, Crawford R, Mao X, Prasadam I (2020) Extracellular vesicles: potential role in osteoarthritis regenerative medicine. J Orthop Translat 21:73–80 PubMed
Xing Z, Zhao C, Liu H, Fan Y (2020) Endothelial progenitor cell-derived extracellular vesicles: a novel candidate for regenerative medicine and disease treatment. Adv Healthc Mater 9:2000255
Xu R, Rai A, Chen M, Suwakulsiri W, Greening DW, Simpson RJ (2018) Extracellular vesicles in cancer: implications for future improvements in cancer care. Nat Rev Clin Oncol 15:617–638 PubMedPubMedCentral
Xu J, Liu Y, Hsu S-h (2019) Hydrogels based on Schiff base linkages for biomedical applications. Molecules 24:3005 PubMedCentral
Yu Y, Xu S, Li S, Pan H (2021) Genipin-cross-linked hydrogels based on biomaterials for drug delivery: a review, Biomater Sci
Zhang Y, Wang W-T, Gong C-R, Li C, Shi M (2020) Combination of olfactory ensheathing cells and human umbilical cord mesenchymal stem cell-derived exosomes promotes sciatic nerve regeneration. Neural Regen Res 15:1903 PubMedPubMedCentral
Zhao D, Yu S, Sun B, Gao S, Guo S, Zhao K (2018) Biomedical applications of chitosan and its derivative nanoparticles. Polymers 10:462 PubMedCentral
Zhao J et al (2020) Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury. Stem Cell Res Ther 11:1–17
Zhao X et al (2021) Chitosan hydrogel-loaded MSC-derived extracellular vesicles promote skin rejuvenation by ameliorating the senescence of dermal fibroblasts. Stem Cell Res Ther 12:1–15
Zhou Y et al (2013) Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro. Stem Cell Res Ther 4:1–13
Metadata
Title
Chitosan hydrogel, as a biological macromolecule-based drug delivery system for exosomes and microvesicles in regenerative medicine: a mini review
Authors
Lan Guo
Yali Guan
Peng Liu
Linghuan Gao
Zhifu Wang
Shengli Huang
Liang Peng
Zhiyu Zhao
Publication date
27-01-2022
Publisher
Springer Netherlands
Published in
Cellulose / Issue 3/2022
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI
https://doi.org/10.1007/s10570-021-04330-7

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