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Published in: Cellulose 3/2022

27-01-2022 | Review Paper

Chitosan hydrogel, as a biological macromolecule-based drug delivery system for exosomes and microvesicles in regenerative medicine: a mini review

Authors: Lan Guo, Yali Guan, Peng Liu, Linghuan Gao, Zhifu Wang, Shengli Huang, Liang Peng, Zhiyu Zhao

Published in: Cellulose | Issue 3/2022

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Abstract

Extracellular vesicles are membrane-packed entities that are involved in various physiological and pathological processes. Recently, the role of exosomes and microvesicles in regenerative medicine has been elucidated. Indeed, therapeutic potential of stem cells may be partly due to exosomes or microvesicles. However, injection of these vesicles may lead to their rapid clearance from the injection site. To address this challenge, different delivery systems for these vesicles’ sustained delivery have been developed. In this regard, chitosan based hydrogels have been successfully utilized as delivery platforms for exosomes and microvesicles. In the current review, the prospects, challenges, and applications of chitosan-based hydrogels as a delivery vehicle for exosomes and microvesicles will be discussed.

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Metadata
Title
Chitosan hydrogel, as a biological macromolecule-based drug delivery system for exosomes and microvesicles in regenerative medicine: a mini review
Authors
Lan Guo
Yali Guan
Peng Liu
Linghuan Gao
Zhifu Wang
Shengli Huang
Liang Peng
Zhiyu Zhao
Publication date
27-01-2022
Publisher
Springer Netherlands
Published in
Cellulose / Issue 3/2022
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI
https://doi.org/10.1007/s10570-021-04330-7